Abstract：
:The pathophysiology of systemic lupus erythematosus (SLE) has been very well described in many organs. However, the relation between extracellular matrix changes and lung dynamic mechanical behaviour deserves elucidation. To that end, pulmonary mechanics, lung morphometry and the amount of collagen and elastic fibres in the alveolar septa were analysed in mice with SLE [NZB/W (New Zealand Black/White) F1] and non-diseased NZW mice (control). Static (E(st)) and dynamic (E(dyn)) elastances, difference between dynamic and static elastances (DeltaE), airway resistance (R(aw)) and viscoelastic/inhomogeneous pressure (DeltaP(2)) were determined by the end-inflation occlusion method. Lungs were removed and prepared for histology. E(st), E(dyn), DeltaE and DeltaP(2) were higher in SLE than in control group, while R(aw) was similar in both groups. SLE group showed alveolar collapse and increased amount of elastic and collagen fibres. In conclusion, SLE mice showed an increase in elastic and viscoelastic/inhomogeneous pressures that was accompanied by deposition of collagen and elastic fibres in the alveolar septa.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Souza-Fernandes AB,Rocco PR,Contador RS,Menezes SL,Faffe DS,Negri EM,Capelozzi VL,Zin WAdoi
10.1016/j.resp.2005.09.005keywords:
subject
Has Abstractpub_date
2006-08-01 00:00:00pages
107-14issue
1eissn
1569-9048issn
1878-1519pii
S1569-9048(05)00253-3journal_volume
153pub_type
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journal_title：Respiratory physiology & neurobiology
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
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更新日期：2006-10-27 00:00:00
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journal_title：Respiratory physiology & neurobiology
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doi：10.1016/s0034-5687(01)00337-1
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