Abstract:
:Using a somatostatin-gold conjugate of known biological activity, high affinity binding sites for this neuropeptide were visualized at cellular resolution on cultured diencephalic astrocytes and on frozen sections of the rat diencephalon. Binding could be completely suppressed in competition experiments with surplus unlabeled somatostatin. On sections, the ligand was displaced from its binding sites by 10 microM guanosine triphosphate indicating a functional significance of the labeled structures. As with the native peptide, a surplus of the analog SMS 201-995 suppressed nearly all staining. The ligand was bound to distinct populations of astrocytes, namely to those in subependymal and perivascular positions, to astrocytes in somatostatin-innervated hypothalamic nuclei in the mid-sagittal plane and to borderline regions of circumventricular organs. A general mismatch between the distribution of somatostatin-immunoreactive terminals and the pattern of binding of the ligand does not exist. This, together with the competition experiments, suggests a functional relationship between the somatostatin-releasing neurons and associated astrocytes.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Krisch B,Buchholz C,Mentlein Rdoi
10.1007/BF00318767subject
Has Abstractpub_date
1991-02-01 00:00:00pages
253-63issue
2eissn
0302-766Xissn
1432-0878journal_volume
263pub_type
杂志文章abstract::Recent studies have accomplished the establishment of a collagenous fiber-fringe matrix upon dental root surfaces in vitro. The present study was undertaken to follow the development of such a matrix in vitro and to test the possible effects of root surface treatments upon this matrix. Periodontal ligament cells, 0.1 ...
journal_title:Cell and tissue research
pub_type: 杂志文章
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更新日期:1989-10-01 00:00:00
abstract::Light microscopy of native preparations, histology, and electron microscopy have revealed that Phlebotomus duboscqi belongs to a class of sand fly species with prompt development of the peritrophic matrix (PM). Secretion of electron-lucent fibrils, presumably chitin, starts immediately after the ingestion of a blood m...
journal_title:Cell and tissue research
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00217224
更新日期:1984-01-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00233613
更新日期:1980-01-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/BF00215904
更新日期:1986-01-01 00:00:00
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journal_title:Cell and tissue research
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abstract::The acrosome is a special organelle that develops from the Golgi apparatus and the endolysosomal compartment in the spermatids. Centromere protein E (CENP-E) is an essential kinesin motor in chromosome congression and alignment. This study is aimed at investigating the roles and mechanisms of kinesin-7 CENP-E in the f...
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journal_title:Cell and tissue research
pub_type: 杂志文章
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journal_title:Cell and tissue research
pub_type: 杂志文章
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journal_title:Cell and tissue research
pub_type: 杂志文章
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journal_title:Cell and tissue research
pub_type: 杂志文章
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更新日期:1983-01-01 00:00:00
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journal_title:Cell and tissue research
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更新日期:2002-11-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00219984
更新日期:1977-07-11 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
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更新日期:2011-04-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
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更新日期:1979-05-25 00:00:00
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pub_type: 杂志文章
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journal_title:Cell and tissue research
pub_type: 杂志文章
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更新日期:2001-06-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
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journal_title:Cell and tissue research
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journal_title:Cell and tissue research
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journal_title:Cell and tissue research
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journal_title:Cell and tissue research
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journal_title:Cell and tissue research
pub_type: 杂志文章
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更新日期:1995-12-01 00:00:00
abstract::The globiferous pedicellariae of Psammechinus miliaris are described. Two fixation methods giving minimal distortion and rapid tissue hardening were adapted for soft tissue preparation for scanning electron microscopy. The pedicellarial valves are covered by a microvillous epithelium. The outer valve epithelial microv...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00220184
更新日期:1975-10-13 00:00:00
abstract::The production of nerve growth factor (NGF) in peripheral organs may play a role in the pathophysiology of hypertension and in obstructive disorders of the bladder outlet. We have been examining the cellular processes of NGF delivery and secretion in smooth muscle. NGF secretion from vascular smooth muscle cells (VSMC...
journal_title:Cell and tissue research
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journal_title:Cell and tissue research
pub_type: 杂志文章
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更新日期:1975-08-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218867
更新日期:1989-12-01 00:00:00
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journal_title:Cell and tissue research
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journal_title:Cell and tissue research
pub_type: 杂志文章
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更新日期:2002-09-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-009-0770-5
更新日期:2009-05-01 00:00:00