The location of LH-RH neurons in the rat hypothalamus and their pathways to the median eminence. Experimental immunohistochemistry and radioimmunoassay.

Abstract:

:The location of the perikarya of LH-RH neurons in the rat hypothalamus and their pathways to the median eminence were studied by immunohistochemistry and radioimmunoassay after placing stereotaxic electrolytic lesions in several parts of the hypothalamus. The principal location of the cell somata was found to be in the ventral part of the medial preoptic area; their pathways were classified into a main baso-lateral pathway and an accessory descending pathway branching off from the former. The main pathway was found to cross in the vicinity of the corresponding neuronal perikarya. The central median eminence and the dorsal and ventral walls of the tubero-infundibular sulcus of the caudal part of the median eminence are innervated mainly by the baso-lateral pathway. On the other hand, the rostral and most caudal protions of the median eminence are innervated principally by the descending pathway and have a subsidiary dual innervation. The projection of LH-RH neurons to the OVLT is believed to originate from perikarya adjacent to this circumventricular organ.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Ibata Y,Watanabe K,Kinoshita H,Kubo S,Sano Y,Sin S,Hashimura E,Imagawa K

doi

10.1007/BF00234184

subject

Has Abstract

pub_date

1979-05-25 00:00:00

pages

381-95

issue

3

eissn

0302-766X

issn

1432-0878

journal_volume

198

pub_type

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