Androgen physiology.

abstract：:Noncommunicable diseases (NCDs), long considered diseases of little significance to global health, represent the greatest threat to economic development and human health. The main NCDs-diabetes, cancer, cardiovascular disease, and chronic respiratory disease-are the world's number one killer and bear the greatest burd...

journal_title：Seminars in reproductive medicine

authors： Marrero S,Adashi EY

更新日期：2015-01-01 00:00:00

abstract：:There is increasing evidence that endometriosis is inherited as a complex genetic trait in which multiple genes conferring disease susceptibility interact with each other and the environment to produce the phenotype. Research groups worldwide are trying to identify such susceptibility genes through a "positional cloni...

journal_title：Seminars in reproductive medicine

authors： Kennedy S

更新日期：2003-05-01 00:00:00

abstract：:The birth of a child with ambiguous genitalia is a challenging and distressing event for the family and physician and one with life-long consequences. Most disorders of sexual differentiation (DSD) associated with ambiguous genitalia are the result either of inappropriate virilization of girls or incomplete virilizati...

journal_title：Seminars in reproductive medicine

authors： Wilson JD,Rivarola MA,Mendonca BB,Warne GL,Josso N,Drop SL,Grumbach MM

更新日期：2012-10-01 00:00:00

abstract：:The implementation of suitable quality control (QC) is not only required for the accreditation of a human in vitro fertilization (IVF) laboratory, but is also fundamental to its success. Several assays have been employed to screen culture media and contact supplies. The suitability of one assay in particular, the mous...

journal_title：Seminars in reproductive medicine

authors： Gardner DK,Reed L,Linck D,Sheehan C,Lane M

更新日期：2005-11-01 00:00:00

abstract：:Research translation and evaluation are often underconsidered in research design and implementation thus limiting research benefit to the end user. In this article, we first describe a best practice approach to evaluation, for a center of research excellence in polycystic ovary syndrome. Within this, we outline a comp...

journal_title：Seminars in reproductive medicine

authors： Garad R,Kozica-Olenski S,Teede HJ

更新日期：2018-01-01 00:00:00

abstract：:Most of the patients with 5α-RD 2 deficiency are reared in the female social sex due to their severely undervirilized external genitalia but ~60% who have not been submitted to orchiectomy in childhood undergo male social sex change at puberty. In our cohort of 30 cases from 18 families, all subjects were registered i...

journal_title：Seminars in reproductive medicine

authors： Costa EM,Domenice S,Sircili MH,Inacio M,Mendonca BB

更新日期：2012-10-01 00:00:00

abstract：:In vitro fertilization (IVF) with ovarian stimulation is an effective treatment for couples needing treatment with assisted reproductive technologies (ART) where polycystic ovary syndrome (PCOS) is coexisting. However, it is also associated with an increased risk of ovarian hyperstimulation syndrome. In vitro maturati...

journal_title：Seminars in reproductive medicine

authors： Reinblatt SL,Buckett W

更新日期：2008-01-01 00:00:00

abstract：:Male infertility is a condition that affects approximately 50% of infertile couples and about 30% of those couples have only male factor infertility identified. There has been speculation that male military service members may have an even greater lifetime prevalence of infertility as compared to the general populatio...

journal_title：Seminars in reproductive medicine

authors： Reed-Maldonado AB,Madden KC

更新日期：2019-01-01 00:00:00

abstract：:Complementary therapies and medicines are a broad and diverse range of treatments, and are frequently used by women and their partners during the preconception period to assist with infertility, and to address pregnancy-related conditions. Despite frequent use, the evidence examining the efficacy, effectiveness, and s...

journal_title：Seminars in reproductive medicine

authors： Smith CA,Armour M,Ee C

更新日期：2016-03-01 00:00:00

abstract：:The maternal-fetal environment plays an important role in developmental programming of adult disease. Metabolic and hormonal dysfunction during human fetal development accompanies gestational diabetes as a common occurrence in mothers with polycystic ovary syndrome (PCOS), while human fetal androgen excess from congen...

journal_title：Seminars in reproductive medicine

authors： Dumesic DA,Goodarzi MO,Chazenbalk GD,Abbott DH

更新日期：2014-05-01 00:00:00

abstract：:Intrauterine insemination (IUI) is a widely used fertility treatment for couples with male and/or non-male factor infertility and is a relatively simple and inexpensive procedure. When used for unexplained infertility, IUI combined with ovarian stimulation increases the pregnancy rates, but evidence does not support t...

journal_title：Seminars in reproductive medicine

authors： Kim YJ,Park CW,Ku SY

更新日期：2014-07-01 00:00:00

abstract：:Endocrine disrupters are exogenous substances that cause adverse effects in the endocrine system. Sexual differentiation is regulated by reproductive hormones. Male differentiation is critically dependent on normal androgen action, which in turn depends on normal production of luteinizing hormone. Other essential horm...

journal_title：Seminars in reproductive medicine

authors： Toppari J

更新日期：2002-08-01 00:00:00

abstract：:Female genital tract microbiota play a crucial role in maintaining health. Disequilibrium of the microbiota has been associated with increased risk of pelvic infections. In recent years, culture-independent molecular techniques have expanded understanding of the composition of genital microbiota and the dynamic nature...

journal_title：Seminars in reproductive medicine

authors： Sharma H,Tal R,Clark NA,Segars JH

更新日期：2014-01-01 00:00:00

abstract：:Translocations involving the X and Y chromosomes are often associated with anomalies of gonadal development. Transfer of Yp sequences, including the testis-determining SRY gene, to the terminal portion of the short arm of the X chromosome is associated with 46,XX maleness and in rare cases 46,XX true hermaphroditism. ...

journal_title：Seminars in reproductive medicine

authors： McElreavey K,Cortes LS

更新日期：2001-06-01 00:00:00

abstract：:As sperm traverse the female tract from vagina to oocyte, they experience a steroid milieu, which due to transcriptional inactivity, they can only respond to via non-genomic signaling. This environment mediates events including capacitation, changes in motility patterns, chemotaxis, and acrosome reaction. Current know...

journal_title：Seminars in reproductive medicine

authors： Correia JN,Conner SJ,Kirkman-Brown JC

更新日期：2007-05-01 00:00:00

abstract：:There have been few formal studies of differences in the phenotype of PCOS among women of African-American ancestry. Generally, African-American women tend to have an adverse cardiovascular risk profile when compared with women of other racial groups. The metabolic syndrome is a clinical disorder that identifies indiv...

journal_title：Seminars in reproductive medicine

authors： Coney P,Ladson G,Sweet S,Legro RS

更新日期：2008-01-01 00:00:00

abstract：:The ability of glycerol to protect cells from freezing injury was discovered accidentally. The subsequent development of cryopreservation techniques has had a huge impact in many fields, most notably in reproductive medicine. Freezing injury has been shown to have two components, direct damage from the ice crystals an...

journal_title：Seminars in reproductive medicine

authors： Pegg DE

更新日期：2002-02-01 00:00:00

abstract：:Analysis of published series reveals that no more than a fourth of subfertile patients undergoing surgery for peritoneal endometriotic implants, rectovaginal endometriotic lesions, or recurrent endometriomas achieved conception spontaneously. First-line surgery for ovarian endometriotic cysts appears associated with a...

journal_title：Seminars in reproductive medicine

authors： Berlanda N,Vercellini P,Somigliana E,Frattaruolo MP,Buggio L,Gattei U

更新日期：2013-03-01 00:00:00

abstract：:Vasomotor symptoms, including hot flushes and night sweats, pose a significant symptomatic burden to women undergoing menopause, and negatively impact on both their physical and psychological well-being. Management of these symptoms can be challenging, with the use of conventional hormone replacement therapy limited b...

journal_title：Seminars in reproductive medicine

authors： Modi M,Dhillo WS

更新日期：2019-05-01 00:00:00

abstract：:In this article the role of LH receptor gene mutations in patients with aberrant sex differentiation is discussed. In a dominant autosomal familial form of precocious puberty in boys (familial male-limited precocious puberty) LH receptor gene mutations have been identified. These single amino acid changes, mostly foun...

journal_title：Seminars in reproductive medicine

authors： Themmen AP,Verhoef-Post M

更新日期：2002-08-01 00:00:00

abstract：:Controlled ovarian stimulation (COS) is widely used in assisted reproduction techniques (ART). However, hormonal treatment induces endometrial alterations that may alter implantation rates compared with natural cycles. Endometrial alterations have been observed by histological and biochemical techniques. The recent de...

journal_title：Seminars in reproductive medicine

authors： Horcajadas JA,Díaz-Gimeno P,Pellicer A,Simón C

更新日期：2007-11-01 00:00:00

abstract：:Obesity-related infertility is one of the most common problems of reproductive-age obese women who desire childbearing. The various types of bariatric surgeries have proved effective in controlling excessive weight gain, improving fertility, and preventing certain maternal and fetal complications in these women. This ...

journal_title：Seminars in reproductive medicine

authors： Tan O,Carr BR

更新日期：2012-12-01 00:00:00

abstract：:Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) share a common receptor in gonadal cells; however, the presence of these receptors has also been detected in several nongonadal but reproduction-associated tissues of pig, human, and other species. There are no data about the ontogeny of the human LH/hCG ...

journal_title：Seminars in reproductive medicine

authors： Ziecik AJ,Derecka K,Gawronska B,Stepien A,Bodek G

更新日期：2001-01-01 00:00:00

abstract：:Historically, progesterone functions to regulate gene expression via two nuclear progesterone receptors (PR-B and PR-A). Yet, actions of progesterone independent of gene regulation have been observed for decades. These are based on progesterone induced cellular events that occur too rapidly to involve gene transcripti...

journal_title：Seminars in reproductive medicine

authors： Price TM,Dai Q

更新日期：2015-05-01 00:00:00

abstract：:Old World monkeys display physiological responses to steroid hormones that are similar to those of women. In this review, we describe cyclic morphological changes that take place within the uterus of Old World primates during the menstrual cycle. In primates, estrogen stimulates endometrial growth in the follicular ph...

journal_title：Seminars in reproductive medicine

authors： Slayden OD

更新日期：2014-09-01 00:00:00

abstract：:The contribution of embryo cryopreservation to the birth rate per in vitro fertilization cycle has escalated from a rare subsidy to a vital tool that is called upon to augment the cycle outcome. Embryology laboratories must identify the embryo stage, quality criteria and methodology that will optimize their ability to...

journal_title：Seminars in reproductive medicine

authors： Sparks AE

更新日期：2015-03-01 00:00:00

abstract：:Couples experiencing recurrent pregnancy loss are often concerned that toxins within the environment have contributed to their reproductive difficulty. Questions posed by these couples to their health care providers are difficult to answer because scientifically accurate information regarding the reproductive impact o...

journal_title：Seminars in reproductive medicine

authors： Gardella JR,Hill JA 3rd

更新日期：2000-01-01 00:00:00

abstract：:HOX genes, encoding homeodomain transcription factors, are dynamically expressed in endometrium, where they are necessary for endometrial growth, differentiation, and implantation. In human endometrium, the expression of HOXA10 and HOXA11 is driven by sex steroids, with peak expression occurring at time of implantatio...

journal_title：Seminars in reproductive medicine

authors： Cakmak H,Taylor HS

更新日期：2010-01-01 00:00:00

abstract：:Sperm epigenetic programming is tailored to meet the need of this specialized cell, which include its interaction with the oocyte during fertilization and early embryo development. The unique nature of the sperm epigenome has resulted in multiple studies investigating how perturbations in epigenetics might impact male...

journal_title：Seminars in reproductive medicine

authors： Ibrahim Y,Hotaling J

更新日期：2018-05-01 00:00:00

abstract：:This study reviews systematically the effectiveness of management strategies for carriers of a reciprocal translocation involving two chromosomes, ascertained on the basis of recurrent pregnancy loss. Subsequent pregnancy outcomes were tabulated based on whether management was medical or involved in vitro fertilizatio...

journal_title：Seminars in reproductive medicine

authors： Hirshfeld-Cytron J,Sugiura-Ogasawara M,Stephenson MD

更新日期：2011-11-01 00:00:00