Abstract:
:HOX genes, encoding homeodomain transcription factors, are dynamically expressed in endometrium, where they are necessary for endometrial growth, differentiation, and implantation. In human endometrium, the expression of HOXA10 and HOXA11 is driven by sex steroids, with peak expression occurring at time of implantation in response to rising progesterone levels. However, the maximal HOXA10 and HOXA11 expression fails to occur in women with endometriosis. In endometriosis, altered progesterone receptor expression or diminished activity may lead to attenuated or dysregulated progesterone response and decreased expression of progesterone-responsive genes including HOX genes in the eutopic endometrium. In turn, other mediators of endometrial receptivity that are regulated by HOX genes, such as pinopodes, alphavbeta3 integrin, and IGFBP-1, are downregulated in endometriosis. HOXA10 hypermethylation has recently been demonstrated to silence HOXA10 gene expression and account for decreased HOXA10 in the endometrium of women with endometriosis. Silencing of progesterone target genes by methylation is an epigenetic mechanism that mediates progesterone resistance. The relatively permanent nature of methylation may explain the widespread failure of treatments for endometriosis-related infertility.
journal_name
Semin Reprod Medjournal_title
Seminars in reproductive medicineauthors
Cakmak H,Taylor HSdoi
10.1055/s-0029-1242996subject
Has Abstractpub_date
2010-01-01 00:00:00pages
69-74issue
1eissn
1526-8004issn
1526-4564journal_volume
28pub_type
杂志文章,评审abstract::Premature ovarian failure (POF) is a disorder characterized by lack of ovulation and elevated levels of serum gonadotropins before the age of 40. The etiology of POF is not known but different environmental and genetic factors are involved, suggesting high heterogeneity of the disorder. The involvement of X-linked gen...
journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2000-13475
更新日期:2000-01-01 00:00:00
abstract::The United States Agency for International Development (USAID) estimates that there are 225 million women and girls with unmet contraceptive need yearly. Unmet need for contraception is defined as women who desire a delay in childbearing and are not using a modern method of contraception. It is projected that providin...
journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0036-1571437
更新日期:2016-05-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2008-1076144
更新日期:2008-05-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2004-831893
更新日期:2004-08-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2006-948552
更新日期:2006-09-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2002-32506
更新日期:2002-05-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0035-1571194
更新日期:2016-03-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0033-1345272
更新日期:2013-07-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0030-1265678
更新日期:2010-11-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章
doi:10.1055/s-0030-1248135
更新日期:2010-03-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2006-952156
更新日期:2006-11-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0032-1324717
更新日期:2012-10-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2001-13907
更新日期:2001-01-01 00:00:00
abstract::Microfluidics is a young but established field that holds significant potential for scientific discovery. The utility of microfluidics can improve our knowledge of basic biology as well as expand our understanding in specialized areas such as assisted reproduction and stem cell developmental biology. This review descr...
journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0030-1268699
更新日期:2011-01-01 00:00:00
abstract::Trophoblast cells of the murine placenta are derived from the trophectoderm (TE) cells of the preimplantation embryo. Establishment of the TE cell lineage is the result of a cell segregation event early in blastomere division. Models of cell lineage segregation suggest it is driven by the internalization of spatial in...
journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0035-1570025
更新日期:2016-01-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0039-1694027
更新日期:2019-01-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2003-41317
更新日期:2003-05-01 00:00:00
abstract::Endometriosis is a common cause of infertility and disabling pelvic pain in reproductive age women. The most widely accepted theory of its pathogenesis is the retrograde flow of menstrual products, although extra-abdominal and extrapelvic diagnoses have been made. After the pelvic peritoneum and gynecologic structures...
journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0036-1597124
更新日期:2017-01-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0035-1558404
更新日期:2015-09-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0034-1384626
更新日期:2014-11-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2005-869482
更新日期:2005-05-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0031-1287668
更新日期:2011-09-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2005-872452
更新日期:2005-08-01 00:00:00
abstract::Female genital tract microbiota play a crucial role in maintaining health. Disequilibrium of the microbiota has been associated with increased risk of pelvic infections. In recent years, culture-independent molecular techniques have expanded understanding of the composition of genital microbiota and the dynamic nature...
journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0033-1361822
更新日期:2014-01-01 00:00:00
abstract::Endometriosis is a nonmalignant gynecologic disorder that can have a significant impact on a woman's quality of life with pelvic pain and possible lasting effects on one's fertility. Symptoms, when present, can be severe and affect many organ systems including the gastrointestinal and urinary systems. Other etiologies...
journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
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更新日期:2018-03-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 历史文章,杂志文章,评审
doi:10.1055/s-2002-23515
更新日期:2002-02-01 00:00:00
abstract::Polycystic ovary syndrome (PCOS) has become increasingly common over recent years and is associated with reproductive features as well as cardiometabolic risk factors, including visceral obesity, dyslipidemia and impaired glucose homeostasis, and potentially cardiovascular disease. Emerging evidence suggests that thes...
journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0035-1556568
更新日期:2015-07-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2001-15393
更新日期:2001-06-01 00:00:00
abstract::Assisted reproductive techniques have revolutionized the treatment of male reproductive failure, allowing biological fatherhood to be achieved by many men that nature would have never permitted. As we are able to help more and more couples with our therapies, the genetic basis of the man's spermatogenic, anatomical, o...
journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0032-1307418
更新日期:2012-04-01 00:00:00
abstract::The human uterus mainly consists of two layers: an inner endometrium and an outer layer, the myometrium, made of smooth muscle. The uterus is characterized by its unique capacity for regeneration. This capacity permits cyclical regeneration and remodeling of the tissue over the course of a woman's reproductive life. D...
journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0032-1331801
更新日期:2013-01-01 00:00:00