Abstract:
:Obesity is a pandemic and is associated with multiple medical problems including subfertility. Male obesity has been associated with altered semen parameters and reproductive hormonal levels, including a reduced testosterone:estradiol (T:E₂) ratio. Treatment methods employed for obesity-related male subfertility include gonadotropin administration, weight loss, and aromatase inhibitors. Letrozole is a highly effective nonsteroidal aromatase inhibitor that has been used to treat male subfertility in several case series with promising results. Adequately designed randomized controlled studies are needed to produce evidence-based data on the role of aromatase inhibitors in male subfertility management and evaluate the side-effect profile.
journal_name
Semin Reprod Medjournal_title
Seminars in reproductive medicineauthors
Stephens SM,Polotsky AJdoi
10.1055/s-0033-1345272subject
Has Abstractpub_date
2013-07-01 00:00:00pages
251-7issue
4eissn
1526-8004issn
1526-4564journal_volume
31pub_type
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