Somatic stem cells in the myometrium and in myomas.

abstract：:As fertility rates among women of advanced reproductive age have steadily increased, so has the utilization of fertility services. National health policies provide infertility treatment coverage in several developed countries; however, in the United States infertility treatment is largely privately funded, resulting i...

journal_title：Seminars in reproductive medicine

authors： Levens ED,Richter KS,Levy MJ

更新日期：2013-05-01 00:00:00

abstract：:Subclinical hypothyroidism has been found to be associated with adverse reproductive outcomes, such as infertility, miscarriage, preterm birth, and complications of pregnancy. Multiple studies have investigated the relationships between thyroid function, thyroid antibodies, fertility, and pregnancy. Thyroid autoimmuni...

journal_title：Seminars in reproductive medicine

authors： Seungdamrong A

更新日期：2016-11-01 00:00:00

abstract：:As the percentage of women serving in the active-duty military continues to grow, and as their roles continue to expand, the importance of monitoring reproductive health in the military community increases. The Department of Defense Birth and Infant Health Research (BIHR) program conducts ongoing epidemiologic studies...

journal_title：Seminars in reproductive medicine

authors： Khodr ZG,Bukowinski AT,Hall C,Gumbs GR,Wells NY,Conlin AMS

更新日期：2018-11-01 00:00:00

abstract：:Soon after implantation, cell lineages bifurcate into future somatic and germ cells. Canonical expression of germ cell-specific genes continues during and after their migration to the gonadal ridge, where, after further cell cycles, they enter meiosis, form syncytial clusters, and arrest at diplotene for folliculogene...

journal_title：Seminars in reproductive medicine

authors： Gosden RG

更新日期：2013-11-01 00:00:00

abstract：:Exposure to gonadotoxic agents for treating cancer and other diseases or postponement of maternity jeopardize the prospects of genetic parenthood and are major factors driving the development of fertility preservation technologies. Although its mainstays, cryopreservation and vitrification, have been adopted from infe...

journal_title：Seminars in reproductive medicine

authors： Gosden RG

更新日期：2009-11-01 00:00:00

abstract：:Susceptibility to disease begins during fetal life, and adverse events in utero are a critical factor in determining quality of life and overall health. In fact, up to 50% of metabolic syndrome diseases can be attributed to an adverse in utero environment. However, the mechanisms linking impaired fetal development to ...

journal_title：Seminars in reproductive medicine

authors： Sohi G,Revesz A,Hardy DB

更新日期：2011-05-01 00:00:00

abstract：:Identifying appropriate candidates for menopausal hormone therapy (HT) is challenging given the complex profile of risks and benefits associated with treatment. Most professional societies agree that HT should not be used for chronic disease prevention. Recent findings from the Women's Health Initiative and other rand...

journal_title：Seminars in reproductive medicine

authors： Wild RA,Manson JE

更新日期：2014-11-01 00:00:00

abstract：:Reproductive performance may be an important variable in treatment selection for unruptured ectopic pregnancy. The impact of treatment choice on reproductive performance is not known. We searched the literature and then tabulated published case reports on laparoscopic salpingostomy, multiple-dose methotrexate, single-...

journal_title：Seminars in reproductive medicine

authors： Buster JE,Krotz S

更新日期：2007-03-01 00:00:00

abstract：:The number of women in the U.S. military is dramatically increasing. Similarly, the roles of active-duty women are greatly expanding, thus exposing them to new occupational risks. Determining the impact of pregnancy outcomes for women while in the military is difficult due to changing exposures over time, difficulty i...

journal_title：Seminars in reproductive medicine

authors： Mezwa K,Adelsheim L,Markenson G

更新日期：2019-09-01 00:00:00

abstract：:Prior to the advent of modern minimally invasive surgery techniques, the primary surgical management of symptomatic leiomyomata for women desiring future fertility or uterine conservation was through laparotomy. Today, many cases of intramural and subserous leiomyomata are managed with laparoscopic myomectomy and sele...

journal_title：Seminars in reproductive medicine

authors： Advincula AP,Song A

更新日期：2004-05-01 00:00:00

abstract：:Asoprisnil (J 867; benzaldehyde, 4-[(11beta, 17beta)-17-methoxy-17-(methoxymethyl)-3-oxoestra-4, 9-dien-11beta-yl]-, 1-oxime) is the prototype of a novel class 11beta-benzaldoxime-substituted selective progesterone receptor modulators (SPRMs) and the first-in-class SPRM to reach an advanced stage of clinical developme...

journal_title：Seminars in reproductive medicine

authors： Schubert G,Elger W,Kaufmann G,Schneider B,Reddersen G,Chwalisz K

更新日期：2005-02-01 00:00:00

abstract：:Since 2004, assisted conception is encompassed by the European Directive on the Quality and Safety of Tissues and Cells (2004/23/EC). The aim of a standard for quality and safety is to minimize risks of errors, contamination, and accidents and to maximize efficiency of use. This article presents a case study of the im...

journal_title：Seminars in reproductive medicine

authors： Willemen D,D'Hooghe T,Knoops I,De Neubourg D,Spiessens C

更新日期：2012-06-01 00:00:00

abstract：:The Wnt signaling cascade is critically important in stem cell biology, both in homeostatic maintenance and repair and regeneration of tissues and organs, through their respective somatic stem cells (SSCs). However, aberrant Wnt signaling is associated with a wide array of tumor types and Wnt signaling is important in...

journal_title：Seminars in reproductive medicine

authors： Kahn M

更新日期：2015-09-01 00:00:00

abstract：:Whereas the importance of close monitoring and tight glycemic control in diabetic pregnancies cannot be ignored, the growing body of knowledge surrounding the different effects of diabetes mellitus on the earliest stages of reproduction underscores the need for aggressive screening among reproductive-aged women at ris...

journal_title：Seminars in reproductive medicine

authors： Jungheim ES,Moley KH

更新日期：2008-03-01 00:00:00

abstract：:Labor initiation is a complex process that remains to be fully elucidated. An area of active research involves the study of the different mechanisms that may lead to successful signaling for parturition. This review focuses on the fetal-derived signals that lead to the initiation of labor. These signals may also play ...

journal_title：Seminars in reproductive medicine

authors： Beshay VE,Carr BR,Rainey WE

更新日期：2007-01-01 00:00:00

abstract：:Noncommunicable diseases (NCDs), long considered diseases of little significance to global health, represent the greatest threat to economic development and human health. The main NCDs-diabetes, cancer, cardiovascular disease, and chronic respiratory disease-are the world's number one killer and bear the greatest burd...

journal_title：Seminars in reproductive medicine

authors： Marrero S,Adashi EY

更新日期：2015-01-01 00:00:00

abstract：:Analysis of published series reveals that no more than a fourth of subfertile patients undergoing surgery for peritoneal endometriotic implants, rectovaginal endometriotic lesions, or recurrent endometriomas achieved conception spontaneously. First-line surgery for ovarian endometriotic cysts appears associated with a...

journal_title：Seminars in reproductive medicine

authors： Berlanda N,Vercellini P,Somigliana E,Frattaruolo MP,Buggio L,Gattei U

更新日期：2013-03-01 00:00:00

abstract：:Randomized clinical trials (RCTs) have been used to assess interventions affecting health since biblical times. They provide the most valid means of measuring the true effects of intervention compared with no treatment or placebo. Although they can also be used to assess the value of diagnostic tests, this article foc...

journal_title：Seminars in reproductive medicine

authors： Hughes EG

更新日期：2003-02-01 00:00:00

abstract：:The hypothalamus-pituitary-gonadal (HPG) axis is the most critical modulator of reproductive function. Genetic or environmental insults to the HPG axis during developmental windows can persist into adulthood, and processes such as gonadal hormone synthesis, timing of puberty, and fertility can be affected. At the leve...

journal_title：Seminars in reproductive medicine

authors： Biehl MJ,Raetzman LT

更新日期：2017-03-01 00:00:00

abstract：:Successful in utero stem cell transplantations with hematopoietic or other stem cells should represent a major step forward in the management of patients with congenital, hematological, metabolic, and immunological disorders. The possibility of performing cell transplantations with stem cells across histoincompatibili...

journal_title：Seminars in reproductive medicine

authors： Westgren M

更新日期：2006-11-01 00:00:00

abstract：:Women with polycystic ovary syndrome (PCOS) most often seek treatment for reduction of hair growth and/or acne, restoration of menstrual cyclicity, and infertility. In addition, these patients are increasingly seeking advise and treatment for the metabolic abnormalities related to PCOS (e.g., insulin resistance and ty...

journal_title：Seminars in reproductive medicine

authors： Ehrmann DA,Rychlik D

更新日期：2003-08-01 00:00:00

abstract：:Sperm epigenetic programming is tailored to meet the need of this specialized cell, which include its interaction with the oocyte during fertilization and early embryo development. The unique nature of the sperm epigenome has resulted in multiple studies investigating how perturbations in epigenetics might impact male...

journal_title：Seminars in reproductive medicine

authors： Ibrahim Y,Hotaling J

更新日期：2018-05-01 00:00:00

abstract：:In recent years, there has been increasing concern regarding the safety of in vitro fertilization (IVF) because of the potential health impact on these infants. Multiple pregnancy contributes the vast majority of morbidity associated with IVF and, initially, many thought that adverse outcomes after IVF were solely att...

journal_title：Seminars in reproductive medicine

authors： Kalra SK,Molinaro TA

更新日期：2008-09-01 00:00:00

abstract：:Vasomotor symptoms, including hot flushes and night sweats, pose a significant symptomatic burden to women undergoing menopause, and negatively impact on both their physical and psychological well-being. Management of these symptoms can be challenging, with the use of conventional hormone replacement therapy limited b...

journal_title：Seminars in reproductive medicine

authors： Modi M,Dhillo WS

更新日期：2019-05-01 00:00:00

abstract：:Historically, progesterone functions to regulate gene expression via two nuclear progesterone receptors (PR-B and PR-A). Yet, actions of progesterone independent of gene regulation have been observed for decades. These are based on progesterone induced cellular events that occur too rapidly to involve gene transcripti...

journal_title：Seminars in reproductive medicine

authors： Price TM,Dai Q

更新日期：2015-05-01 00:00:00

abstract：:Although the genetic origin of many human diseases and phenotypes has been long and widely recognized, identification of the causative gene alleles has been limited, slow, and cumbersome. This has changed substantially with the introduction of genome-wide association studies (GWASs) a decade ago, fueled by studies and...

journal_title：Seminars in reproductive medicine

authors： Uitterlinden AG

更新日期：2016-07-01 00:00:00

abstract：:Minimally invasive gynecologic surgery is continuously pushing its limits by embracing ever more sophisticated technology. This is also true for reproductive surgery, arguably the birthplace of gynecologic endoscopy, where minimally invasive treatment of uterine, tubal, ovarian, and peritoneal pathology has long becom...

journal_title：Seminars in reproductive medicine

authors： Gargiulo AR,Nezhat C

更新日期：2011-03-01 00:00:00

abstract：:Endometriosis is a common cause of infertility and disabling pelvic pain in reproductive age women. The most widely accepted theory of its pathogenesis is the retrograde flow of menstrual products, although extra-abdominal and extrapelvic diagnoses have been made. After the pelvic peritoneum and gynecologic structures...

journal_title：Seminars in reproductive medicine

authors： Ajao MO,Einarsson JI

更新日期：2017-01-01 00:00:00

abstract：:Gonadotropin-releasing hormone agonist (GnRHa) administration for the induction of oocyte maturation during in vitro fertilization treatment is effective in the prevention of ovarian hyperstimulation syndrome (OHSS). However, some studies have reported a lower ongoing pregnancy rate after GnRHa trigger. The excellent ...

journal_title：Seminars in reproductive medicine

authors： Engmann L,Benadiva C

更新日期：2010-11-01 00:00:00

abstract：:During most of gestation, the fetal adrenal gland is almost solely dedicated to the production of dehydroepiandrosterone sulfate (DHEA-S). This specialized ability of the fetal adrenal is unique to primates and occurs because of a specialized fetal zone that composes the bulk of the fetal adrenal gland. Morphologicall...

journal_title：Seminars in reproductive medicine

authors： Rainey WE,Rehman KS,Carr BR

更新日期：2004-11-01 00:00:00