Neurokinin B and Neurokinin-3 Receptor Signaling: Promising Developments in the Management of Menopausal Hot Flushes.

Abstract:

:Vasomotor symptoms, including hot flushes and night sweats, pose a significant symptomatic burden to women undergoing menopause, and negatively impact on both their physical and psychological well-being. Management of these symptoms can be challenging, with the use of conventional hormone replacement therapy limited by duration of treatment and clinical contraindications. Recent advances in our understanding of the neuroendocrine regulation of the reproductive axis and thermoregulation postmenopause has helped identify a promising new therapeutic target to ameliorate hot flushes. Antagonism of the neurokinin B/neurokinin-3 receptor (NK3R) signaling pathway has emerged as an efficacious treatment in managing vasomotor symptoms, with evidence of rapid and sustained reduction in hot flush frequency and severity and improvements in secondary quality-of-life measures such as sleep. Within this review, we will explore the growing body of evidence supporting the use of NK3R antagonists in the management of vasomotor symptoms, and the possible utility in managing dysfunctional sex-hormone-dependent disorders and glycolipid metabolism disorders such as polycystic ovarian syndrome.

journal_name

Semin Reprod Med

authors

Modi M,Dhillo WS

doi

10.1055/s-0039-3400241

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

125-130

issue

3

eissn

1526-8004

issn

1526-4564

journal_volume

37

pub_type

杂志文章,评审
  • The history and principles of cryopreservation.

    abstract::The ability of glycerol to protect cells from freezing injury was discovered accidentally. The subsequent development of cryopreservation techniques has had a huge impact in many fields, most notably in reproductive medicine. Freezing injury has been shown to have two components, direct damage from the ice crystals an...

    journal_title:Seminars in reproductive medicine

    pub_type: 历史文章,杂志文章,评审

    doi:10.1055/s-2002-23515

    authors: Pegg DE

    更新日期:2002-02-01 00:00:00

  • Randomized clinical trials: the meeting place of medical practice and clinical research.

    abstract::Randomized clinical trials (RCTs) have been used to assess interventions affecting health since biblical times. They provide the most valid means of measuring the true effects of intervention compared with no treatment or placebo. Although they can also be used to assess the value of diagnostic tests, this article foc...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2003-39995

    authors: Hughes EG

    更新日期:2003-02-01 00:00:00

  • Intrauterine environment and polycystic ovary syndrome.

    abstract::The maternal-fetal environment plays an important role in developmental programming of adult disease. Metabolic and hormonal dysfunction during human fetal development accompanies gestational diabetes as a common occurrence in mothers with polycystic ovary syndrome (PCOS), while human fetal androgen excess from congen...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0034-1371087

    authors: Dumesic DA,Goodarzi MO,Chazenbalk GD,Abbott DH

    更新日期:2014-05-01 00:00:00

  • Pelvic pain, adnexal masses, and ultrasound.

    abstract::Pelvic pain, acute or chronic, accounts for more than 10% of referrals to gynecologists. Pain accounts for more than 40% of gynecologic diagnostic laparoscopies. Predicting operative findings is critical in planning surgical interventions, as well as preoperative and postoperative medical therapy. Ultrasound is useful...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1076144

    authors: Shwayder JM

    更新日期:2008-05-01 00:00:00

  • The Department of Defense Birth and Infant Health Research Program: Assessing the Reproductive Health of U.S. Active-Duty Women.

    abstract::As the percentage of women serving in the active-duty military continues to grow, and as their roles continue to expand, the importance of monitoring reproductive health in the military community increases. The Department of Defense Birth and Infant Health Research (BIHR) program conducts ongoing epidemiologic studies...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0039-1678751

    authors: Khodr ZG,Bukowinski AT,Hall C,Gumbs GR,Wells NY,Conlin AMS

    更新日期:2018-11-01 00:00:00

  • Epigenetic transgenerational effects of endocrine disruptors on male reproduction.

    abstract::Endocrine-disrupting chemicals generally function as steroid receptor signaling antagonists or agonists that influence development to promote adult-onset disease. Exposure to the endocrine disruptors during the initiation of male reproductive tract development interferes with the normal hormonal signaling and formatio...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0029-1237428

    authors: Guerrero-Bosagna CM,Skinner MK

    更新日期:2009-09-01 00:00:00

  • Inhibins in normal male physiology.

    abstract::Inhibin is a dimeric glycoprotein that suppresses follicle-stimulating hormone (FSH) secretion from the pituitary. Two bioactive forms of inhibin exist, inhibin A and B. The availability of specific immunoassays for each of the isoforms has enabled the study of the individual inhibins and their physiological roles. In...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2004-831893

    authors: O'Connor AE,De Kretser DM

    更新日期:2004-08-01 00:00:00

  • Human embryo cryopreservation-methods, timing, and other considerations for optimizing an embryo cryopreservation program.

    abstract::The contribution of embryo cryopreservation to the birth rate per in vitro fertilization cycle has escalated from a rare subsidy to a vital tool that is called upon to augment the cycle outcome. Embryology laboratories must identify the embryo stage, quality criteria and methodology that will optimize their ability to...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0035-1546826

    authors: Sparks AE

    更新日期:2015-03-01 00:00:00

  • The impact of bariatric surgery on obesity-related infertility and in vitro fertilization outcomes.

    abstract::Obesity-related infertility is one of the most common problems of reproductive-age obese women who desire childbearing. The various types of bariatric surgeries have proved effective in controlling excessive weight gain, improving fertility, and preventing certain maternal and fetal complications in these women. This ...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0032-1328880

    authors: Tan O,Carr BR

    更新日期:2012-12-01 00:00:00

  • Permanent implications of intrauterine growth restriction on cholesterol homeostasis.

    abstract::Susceptibility to disease begins during fetal life, and adverse events in utero are a critical factor in determining quality of life and overall health. In fact, up to 50% of metabolic syndrome diseases can be attributed to an adverse in utero environment. However, the mechanisms linking impaired fetal development to ...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0031-1275523

    authors: Sohi G,Revesz A,Hardy DB

    更新日期:2011-05-01 00:00:00

  • Non-genomic steroid actions in human spermatozoa. "Persistent tickling from a laden environment".

    abstract::As sperm traverse the female tract from vagina to oocyte, they experience a steroid milieu, which due to transcriptional inactivity, they can only respond to via non-genomic signaling. This environment mediates events including capacitation, changes in motility patterns, chemotaxis, and acrosome reaction. Current know...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2007-973433

    authors: Correia JN,Conner SJ,Kirkman-Brown JC

    更新日期:2007-05-01 00:00:00

  • Insights from the Women's Health Initiative: individualizing risk assessment for hormone therapy decisions.

    abstract::Identifying appropriate candidates for menopausal hormone therapy (HT) is challenging given the complex profile of risks and benefits associated with treatment. Most professional societies agree that HT should not be used for chronic disease prevention. Recent findings from the Women's Health Initiative and other rand...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0034-1384626

    authors: Wild RA,Manson JE

    更新日期:2014-11-01 00:00:00

  • The Emerging Role of Chronic Low-Grade Inflammation in the Pathophysiology of Polycystic Ovary Syndrome.

    abstract::Polycystic ovary syndrome (PCOS) has become increasingly common over recent years and is associated with reproductive features as well as cardiometabolic risk factors, including visceral obesity, dyslipidemia and impaired glucose homeostasis, and potentially cardiovascular disease. Emerging evidence suggests that thes...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0035-1556568

    authors: Shorakae S,Teede H,de Courten B,Lambert G,Boyle J,Moran LJ

    更新日期:2015-07-01 00:00:00

  • Does polycystic ovary syndrome increase the disparity in metabolic syndrome and cardiovascular-related health for African-American women?

    abstract::There have been few formal studies of differences in the phenotype of PCOS among women of African-American ancestry. Generally, African-American women tend to have an adverse cardiovascular risk profile when compared with women of other racial groups. The metabolic syndrome is a clinical disorder that identifies indiv...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2007-992922

    authors: Coney P,Ladson G,Sweet S,Legro RS

    更新日期:2008-01-01 00:00:00

  • Nongonadal LH/hCG receptors in pig: functional importance and parallels to human.

    abstract::Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) share a common receptor in gonadal cells; however, the presence of these receptors has also been detected in several nongonadal but reproduction-associated tissues of pig, human, and other species. There are no data about the ontogeny of the human LH/hCG ...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2001-13907

    authors: Ziecik AJ,Derecka K,Gawronska B,Stepien A,Bodek G

    更新日期:2001-01-01 00:00:00

  • Obstetric Outcomes in Military Servicewomen: Emerging Knowledge, Considerations, and Gaps.

    abstract::The number of women in the U.S. military is dramatically increasing. Similarly, the roles of active-duty women are greatly expanding, thus exposing them to new occupational risks. Determining the impact of pregnancy outcomes for women while in the military is difficult due to changing exposures over time, difficulty i...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章

    doi:10.1055/s-0040-1712929

    authors: Mezwa K,Adelsheim L,Markenson G

    更新日期:2019-09-01 00:00:00

  • Environmental endocrine disrupters and disorders of sexual differentiation.

    abstract::Endocrine disrupters are exogenous substances that cause adverse effects in the endocrine system. Sexual differentiation is regulated by reproductive hormones. Male differentiation is critically dependent on normal androgen action, which in turn depends on normal production of luteinizing hormone. Other essential horm...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2002-35377

    authors: Toppari J

    更新日期:2002-08-01 00:00:00

  • Impact of extracellular matrix remodeling on ovulation and the folliculo-luteal transition.

    abstract::Follicular rupture and the transformation of an estrogenic preovulatory follicle into a highly vascularized corpus luteum capable of producing large quantities of progesterone are required for the establishment of pregnancy. These processes are dependent upon the precise remodeling of the ovarian extracellular matrix ...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2006-948552

    authors: Curry TE Jr,Smith MF

    更新日期:2006-09-01 00:00:00

  • Quality control in human in vitro fertilization.

    abstract::The implementation of suitable quality control (QC) is not only required for the accreditation of a human in vitro fertilization (IVF) laboratory, but is also fundamental to its success. Several assays have been employed to screen culture media and contact supplies. The suitability of one assay in particular, the mous...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2005-923389

    authors: Gardner DK,Reed L,Linck D,Sheehan C,Lane M

    更新日期:2005-11-01 00:00:00

  • Reproductive performance after ectopic pregnancy.

    abstract::Reproductive performance may be an important variable in treatment selection for unruptured ectopic pregnancy. The impact of treatment choice on reproductive performance is not known. We searched the literature and then tabulated published case reports on laparoscopic salpingostomy, multiple-dose methotrexate, single-...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2007-970052

    authors: Buster JE,Krotz S

    更新日期:2007-03-01 00:00:00

  • Role of surgery in endometriosis-associated subfertility.

    abstract::Analysis of published series reveals that no more than a fourth of subfertile patients undergoing surgery for peritoneal endometriotic implants, rectovaginal endometriotic lesions, or recurrent endometriomas achieved conception spontaneously. First-line surgery for ovarian endometriotic cysts appears associated with a...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0032-1333478

    authors: Berlanda N,Vercellini P,Somigliana E,Frattaruolo MP,Buggio L,Gattei U

    更新日期:2013-03-01 00:00:00

  • DSD due to 5α-reductase 2 deficiency - from diagnosis to long term outcome.

    abstract::Most of the patients with 5α-RD 2 deficiency are reared in the female social sex due to their severely undervirilized external genitalia but ~60% who have not been submitted to orchiectomy in childhood undergo male social sex change at puberty. In our cohort of 30 cases from 18 families, all subjects were registered i...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0032-1324727

    authors: Costa EM,Domenice S,Sircili MH,Inacio M,Mendonca BB

    更新日期:2012-10-01 00:00:00

  • Neuroendocrine changes with reproductive aging in women.

    abstract::Aging has dramatic effects on the reproductive system in women. Undoubtedly, the most notable changes in the neuroendocrine axis arise from the loss of ovarian function, and thus, the loss of negative feedback on the hypothalamus and pituitary. Progressive decreases in inhibin B and inhibin A result in an early increa...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2007-984740

    authors: Hall JE

    更新日期:2007-09-01 00:00:00

  • In vitro maturation for patients with polycystic ovary syndrome.

    abstract::In vitro fertilization (IVF) with ovarian stimulation is an effective treatment for couples needing treatment with assisted reproductive technologies (ART) where polycystic ovary syndrome (PCOS) is coexisting. However, it is also associated with an increased risk of ovarian hyperstimulation syndrome. In vitro maturati...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2007-992932

    authors: Reinblatt SL,Buckett W

    更新日期:2008-01-01 00:00:00

  • Pharmacologic treatment of polycystic ovary syndrome.

    abstract::Women with polycystic ovary syndrome (PCOS) most often seek treatment for reduction of hair growth and/or acne, restoration of menstrual cyclicity, and infertility. In addition, these patients are increasingly seeking advise and treatment for the metabolic abnormalities related to PCOS (e.g., insulin resistance and ty...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2003-43305

    authors: Ehrmann DA,Rychlik D

    更新日期:2003-08-01 00:00:00

  • Medical Management of Endometriosis in Patients with Chronic Pelvic Pain.

    abstract::Endometriosis is a common cause of pelvic pain in women of reproductive age. Traditional medical therapies are hormonal in nature, including estrogen-progestin contraceptives, progestins, and gonadotropin-releasing hormone (GnRH) agonists. Other hormonal options are androgens and aromatase inhibitors, with research al...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0036-1597308

    authors: Bedaiwy MA,Allaire C,Yong P,Alfaraj S

    更新日期:2017-01-01 00:00:00

  • Genetics of endometriosis: a review of the positional cloning approaches.

    abstract::There is increasing evidence that endometriosis is inherited as a complex genetic trait in which multiple genes conferring disease susceptibility interact with each other and the environment to produce the phenotype. Research groups worldwide are trying to identify such susceptibility genes through a "positional cloni...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2003-41317

    authors: Kennedy S

    更新日期:2003-05-01 00:00:00

  • Does the European Union Tissues and Cells Directive improve quality in the in vitro fertilization laboratory? A case study in a tertiary referral center.

    abstract::Since 2004, assisted conception is encompassed by the European Directive on the Quality and Safety of Tissues and Cells (2004/23/EC). The aim of a standard for quality and safety is to minimize risks of errors, contamination, and accidents and to maximize efficiency of use. This article presents a case study of the im...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章

    doi:10.1055/s-0032-1311521

    authors: Willemen D,D'Hooghe T,Knoops I,De Neubourg D,Spiessens C

    更新日期:2012-06-01 00:00:00

  • A new function for the LH/CG receptor: transcytosis of hormone across the endothelial barrier in target organs.

    abstract::Gonadotropins cross the vascular endothelial barrier to reach their target organs. Hormone concentrations in blood are very low and fluctuate rapidly to give sharp biological effects. Nonspecific transendothelial transport mechanisms are slow and markedly concentration dependent. There is thus a need for specific tran...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2001-13916

    authors: Ghinea N,Milgrom E

    更新日期:2001-01-01 00:00:00

  • Money-back guarantees.

    abstract::As fertility rates among women of advanced reproductive age have steadily increased, so has the utilization of fertility services. National health policies provide infertility treatment coverage in several developed countries; however, in the United States infertility treatment is largely privately funded, resulting i...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章

    doi:10.1055/s-0033-1336600

    authors: Levens ED,Richter KS,Levy MJ

    更新日期:2013-05-01 00:00:00