Abstract:
:Vasomotor symptoms, including hot flushes and night sweats, pose a significant symptomatic burden to women undergoing menopause, and negatively impact on both their physical and psychological well-being. Management of these symptoms can be challenging, with the use of conventional hormone replacement therapy limited by duration of treatment and clinical contraindications. Recent advances in our understanding of the neuroendocrine regulation of the reproductive axis and thermoregulation postmenopause has helped identify a promising new therapeutic target to ameliorate hot flushes. Antagonism of the neurokinin B/neurokinin-3 receptor (NK3R) signaling pathway has emerged as an efficacious treatment in managing vasomotor symptoms, with evidence of rapid and sustained reduction in hot flush frequency and severity and improvements in secondary quality-of-life measures such as sleep. Within this review, we will explore the growing body of evidence supporting the use of NK3R antagonists in the management of vasomotor symptoms, and the possible utility in managing dysfunctional sex-hormone-dependent disorders and glycolipid metabolism disorders such as polycystic ovarian syndrome.
journal_name
Semin Reprod Medjournal_title
Seminars in reproductive medicineauthors
Modi M,Dhillo WSdoi
10.1055/s-0039-3400241subject
Has Abstractpub_date
2019-05-01 00:00:00pages
125-130issue
3eissn
1526-8004issn
1526-4564journal_volume
37pub_type
杂志文章,评审abstract::The ability of glycerol to protect cells from freezing injury was discovered accidentally. The subsequent development of cryopreservation techniques has had a huge impact in many fields, most notably in reproductive medicine. Freezing injury has been shown to have two components, direct damage from the ice crystals an...
journal_title:Seminars in reproductive medicine
pub_type: 历史文章,杂志文章,评审
doi:10.1055/s-2002-23515
更新日期:2002-02-01 00:00:00
abstract::Randomized clinical trials (RCTs) have been used to assess interventions affecting health since biblical times. They provide the most valid means of measuring the true effects of intervention compared with no treatment or placebo. Although they can also be used to assess the value of diagnostic tests, this article foc...
journal_title:Seminars in reproductive medicine
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2008-1076144
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0039-1678751
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0029-1237428
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0035-1546826
更新日期:2015-03-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0032-1328880
更新日期:2012-12-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0031-1275523
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abstract::As sperm traverse the female tract from vagina to oocyte, they experience a steroid milieu, which due to transcriptional inactivity, they can only respond to via non-genomic signaling. This environment mediates events including capacitation, changes in motility patterns, chemotaxis, and acrosome reaction. Current know...
journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2007-973433
更新日期:2007-05-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0034-1384626
更新日期:2014-11-01 00:00:00
abstract::Polycystic ovary syndrome (PCOS) has become increasingly common over recent years and is associated with reproductive features as well as cardiometabolic risk factors, including visceral obesity, dyslipidemia and impaired glucose homeostasis, and potentially cardiovascular disease. Emerging evidence suggests that thes...
journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0035-1556568
更新日期:2015-07-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2007-992922
更新日期:2008-01-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2001-13907
更新日期:2001-01-01 00:00:00
abstract::The number of women in the U.S. military is dramatically increasing. Similarly, the roles of active-duty women are greatly expanding, thus exposing them to new occupational risks. Determining the impact of pregnancy outcomes for women while in the military is difficult due to changing exposures over time, difficulty i...
journal_title:Seminars in reproductive medicine
pub_type: 杂志文章
doi:10.1055/s-0040-1712929
更新日期:2019-09-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2002-35377
更新日期:2002-08-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2006-948552
更新日期:2006-09-01 00:00:00
abstract::The implementation of suitable quality control (QC) is not only required for the accreditation of a human in vitro fertilization (IVF) laboratory, but is also fundamental to its success. Several assays have been employed to screen culture media and contact supplies. The suitability of one assay in particular, the mous...
journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2005-923389
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2007-970052
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0032-1333478
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0032-1324727
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2007-984740
更新日期:2007-09-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2007-992932
更新日期:2008-01-01 00:00:00
abstract::Women with polycystic ovary syndrome (PCOS) most often seek treatment for reduction of hair growth and/or acne, restoration of menstrual cyclicity, and infertility. In addition, these patients are increasingly seeking advise and treatment for the metabolic abnormalities related to PCOS (e.g., insulin resistance and ty...
journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2003-43305
更新日期:2003-08-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0036-1597308
更新日期:2017-01-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
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更新日期:2003-05-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章
doi:10.1055/s-0032-1311521
更新日期:2012-06-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2001-13916
更新日期:2001-01-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章
doi:10.1055/s-0033-1336600
更新日期:2013-05-01 00:00:00