The Role of a Mitochondrial Progesterone Receptor (PR-M) in Progesterone Action.

Abstract:

:Historically, progesterone functions to regulate gene expression via two nuclear progesterone receptors (PR-B and PR-A). Yet, actions of progesterone independent of gene regulation have been observed for decades. These are based on progesterone induced cellular events that occur too rapidly to involve gene transcription or in cells lacking active gene transcription such as mature spermatozoa. Understanding of these "nongenomic" effects has been slowed by the lack of identification of specific receptors. Previous discovery of a mitochondrial progesterone receptor, PR-M, has opened up the possibility of direct, ligand-dependent modulation of mitochondrial activity. In this article, we review the current knowledge of PR-M and speculate on possible physiologic and pathophysiologic actions.

journal_name

Semin Reprod Med

authors

Price TM,Dai Q

doi

10.1055/s-0035-1552583

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

185-94

issue

3

eissn

1526-8004

issn

1526-4564

journal_volume

33

pub_type

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