Noncommunicable diseases.

abstract：:Intraperitoneal adhesions remain a costly, long-term sequela of abdominal surgery. They cause significant postoperative morbidity and difficult reoperative surgery. Although adhesions have been recognized for more than 250 years, a uniformly effective method of adhesion prevention does not exist. In recent years, rese...

journal_title：Seminars in reproductive medicine

authors： Reed KL,Stucchi AF,Becker JM

更新日期：2008-07-01 00:00:00

abstract：:Most of the patients with 5α-RD 2 deficiency are reared in the female social sex due to their severely undervirilized external genitalia but ~60% who have not been submitted to orchiectomy in childhood undergo male social sex change at puberty. In our cohort of 30 cases from 18 families, all subjects were registered i...

journal_title：Seminars in reproductive medicine

authors： Costa EM,Domenice S,Sircili MH,Inacio M,Mendonca BB

更新日期：2012-10-01 00:00:00

abstract：:Couples experiencing recurrent pregnancy loss are often concerned that toxins within the environment have contributed to their reproductive difficulty. Questions posed by these couples to their health care providers are difficult to answer because scientifically accurate information regarding the reproductive impact o...

journal_title：Seminars in reproductive medicine

authors： Gardella JR,Hill JA 3rd

更新日期：2000-01-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) has become increasingly common over recent years and is associated with reproductive features as well as cardiometabolic risk factors, including visceral obesity, dyslipidemia and impaired glucose homeostasis, and potentially cardiovascular disease. Emerging evidence suggests that thes...

journal_title：Seminars in reproductive medicine

authors： Shorakae S,Teede H,de Courten B,Lambert G,Boyle J,Moran LJ

更新日期：2015-07-01 00:00:00

abstract：:Susceptibility to disease begins during fetal life, and adverse events in utero are a critical factor in determining quality of life and overall health. In fact, up to 50% of metabolic syndrome diseases can be attributed to an adverse in utero environment. However, the mechanisms linking impaired fetal development to ...

journal_title：Seminars in reproductive medicine

authors： Sohi G,Revesz A,Hardy DB

更新日期：2011-05-01 00:00:00

abstract：:Inhibin is a dimeric glycoprotein that suppresses follicle-stimulating hormone (FSH) secretion from the pituitary. Two bioactive forms of inhibin exist, inhibin A and B. The availability of specific immunoassays for each of the isoforms has enabled the study of the individual inhibins and their physiological roles. In...

journal_title：Seminars in reproductive medicine

authors： O'Connor AE,De Kretser DM

更新日期：2004-08-01 00:00:00

abstract：:In vitro fertilization (IVF) with ovarian stimulation is an effective treatment for couples needing treatment with assisted reproductive technologies (ART) where polycystic ovary syndrome (PCOS) is coexisting. However, it is also associated with an increased risk of ovarian hyperstimulation syndrome. In vitro maturati...

journal_title：Seminars in reproductive medicine

authors： Reinblatt SL,Buckett W

更新日期：2008-01-01 00:00:00

abstract：:Asoprisnil (J 867; benzaldehyde, 4-[(11beta, 17beta)-17-methoxy-17-(methoxymethyl)-3-oxoestra-4, 9-dien-11beta-yl]-, 1-oxime) is the prototype of a novel class 11beta-benzaldoxime-substituted selective progesterone receptor modulators (SPRMs) and the first-in-class SPRM to reach an advanced stage of clinical developme...

journal_title：Seminars in reproductive medicine

authors： Schubert G,Elger W,Kaufmann G,Schneider B,Reddersen G,Chwalisz K

更新日期：2005-02-01 00:00:00

abstract：:Approximately 10 to 15% of the population experiences infertility. Although 85 to 90% of couples or individuals who experience infertility have a diagnosis for their infertility, underlying causes of infertility rarely are found. Extensive literature reporting adverse effects of environmental contaminants on wildlife ...

journal_title：Seminars in reproductive medicine

authors： Giudice LC

更新日期：2006-07-01 00:00:00

abstract：:Endometriosis is a common cause of infertility and disabling pelvic pain in reproductive age women. The most widely accepted theory of its pathogenesis is the retrograde flow of menstrual products, although extra-abdominal and extrapelvic diagnoses have been made. After the pelvic peritoneum and gynecologic structures...

journal_title：Seminars in reproductive medicine

authors： Ajao MO,Einarsson JI

更新日期：2017-01-01 00:00:00

abstract：:Pelvic pain, acute or chronic, accounts for more than 10% of referrals to gynecologists. Pain accounts for more than 40% of gynecologic diagnostic laparoscopies. Predicting operative findings is critical in planning surgical interventions, as well as preoperative and postoperative medical therapy. Ultrasound is useful...

journal_title：Seminars in reproductive medicine

authors： Shwayder JM

更新日期：2008-05-01 00:00:00

abstract：:HOX genes, encoding homeodomain transcription factors, are dynamically expressed in endometrium, where they are necessary for endometrial growth, differentiation, and implantation. In human endometrium, the expression of HOXA10 and HOXA11 is driven by sex steroids, with peak expression occurring at time of implantatio...

journal_title：Seminars in reproductive medicine

authors： Cakmak H,Taylor HS

更新日期：2010-01-01 00:00:00

abstract：:Vasomotor symptoms, including hot flushes and night sweats, pose a significant symptomatic burden to women undergoing menopause, and negatively impact on both their physical and psychological well-being. Management of these symptoms can be challenging, with the use of conventional hormone replacement therapy limited b...

journal_title：Seminars in reproductive medicine

authors： Modi M,Dhillo WS

更新日期：2019-05-01 00:00:00

abstract：:Complementary therapies and medicines are a broad and diverse range of treatments, and are frequently used by women and their partners during the preconception period to assist with infertility, and to address pregnancy-related conditions. Despite frequent use, the evidence examining the efficacy, effectiveness, and s...

journal_title：Seminars in reproductive medicine

authors： Smith CA,Armour M,Ee C

更新日期：2016-03-01 00:00:00

abstract：:Gonadotropins cross the vascular endothelial barrier to reach their target organs. Hormone concentrations in blood are very low and fluctuate rapidly to give sharp biological effects. Nonspecific transendothelial transport mechanisms are slow and markedly concentration dependent. There is thus a need for specific tran...

journal_title：Seminars in reproductive medicine

authors： Ghinea N,Milgrom E

更新日期：2001-01-01 00:00:00

abstract：:The ability of glycerol to protect cells from freezing injury was discovered accidentally. The subsequent development of cryopreservation techniques has had a huge impact in many fields, most notably in reproductive medicine. Freezing injury has been shown to have two components, direct damage from the ice crystals an...

journal_title：Seminars in reproductive medicine

authors： Pegg DE

更新日期：2002-02-01 00:00:00

abstract：:Intrauterine insemination (IUI) is a widely used fertility treatment for couples with male and/or non-male factor infertility and is a relatively simple and inexpensive procedure. When used for unexplained infertility, IUI combined with ovarian stimulation increases the pregnancy rates, but evidence does not support t...

journal_title：Seminars in reproductive medicine

authors： Kim YJ,Park CW,Ku SY

更新日期：2014-07-01 00:00:00

abstract：:Soon after implantation, cell lineages bifurcate into future somatic and germ cells. Canonical expression of germ cell-specific genes continues during and after their migration to the gonadal ridge, where, after further cell cycles, they enter meiosis, form syncytial clusters, and arrest at diplotene for folliculogene...

journal_title：Seminars in reproductive medicine

authors： Gosden RG

更新日期：2013-11-01 00:00:00

abstract：:Aging has dramatic effects on the reproductive system in women. Undoubtedly, the most notable changes in the neuroendocrine axis arise from the loss of ovarian function, and thus, the loss of negative feedback on the hypothalamus and pituitary. Progressive decreases in inhibin B and inhibin A result in an early increa...

journal_title：Seminars in reproductive medicine

authors： Hall JE

更新日期：2007-09-01 00:00:00

abstract：:Women with polycystic ovary syndrome (PCOS) most often seek treatment for reduction of hair growth and/or acne, restoration of menstrual cyclicity, and infertility. In addition, these patients are increasingly seeking advise and treatment for the metabolic abnormalities related to PCOS (e.g., insulin resistance and ty...

journal_title：Seminars in reproductive medicine

authors： Ehrmann DA,Rychlik D

更新日期：2003-08-01 00:00:00

abstract：:Controlled ovarian stimulation (COS) is widely used in assisted reproduction techniques (ART). However, hormonal treatment induces endometrial alterations that may alter implantation rates compared with natural cycles. Endometrial alterations have been observed by histological and biochemical techniques. The recent de...

journal_title：Seminars in reproductive medicine

authors： Horcajadas JA,Díaz-Gimeno P,Pellicer A,Simón C

更新日期：2007-11-01 00:00:00

abstract：:The implementation of suitable quality control (QC) is not only required for the accreditation of a human in vitro fertilization (IVF) laboratory, but is also fundamental to its success. Several assays have been employed to screen culture media and contact supplies. The suitability of one assay in particular, the mous...

journal_title：Seminars in reproductive medicine

authors： Gardner DK,Reed L,Linck D,Sheehan C,Lane M

更新日期：2005-11-01 00:00:00

abstract：:Translocations involving the X and Y chromosomes are often associated with anomalies of gonadal development. Transfer of Yp sequences, including the testis-determining SRY gene, to the terminal portion of the short arm of the X chromosome is associated with 46,XX maleness and in rare cases 46,XX true hermaphroditism. ...

journal_title：Seminars in reproductive medicine

authors： McElreavey K,Cortes LS

更新日期：2001-06-01 00:00:00

abstract：:Minimally invasive gynecologic surgery is continuously pushing its limits by embracing ever more sophisticated technology. This is also true for reproductive surgery, arguably the birthplace of gynecologic endoscopy, where minimally invasive treatment of uterine, tubal, ovarian, and peritoneal pathology has long becom...

journal_title：Seminars in reproductive medicine

authors： Gargiulo AR,Nezhat C

更新日期：2011-03-01 00:00:00

abstract：:Although the genetic origin of many human diseases and phenotypes has been long and widely recognized, identification of the causative gene alleles has been limited, slow, and cumbersome. This has changed substantially with the introduction of genome-wide association studies (GWASs) a decade ago, fueled by studies and...

journal_title：Seminars in reproductive medicine

authors： Uitterlinden AG

更新日期：2016-07-01 00:00:00

abstract：:Chromosome abnormalities are extremely common in human oocytes and embryos and are associated with a variety of negative outcomes for both natural cycles and those using assisted conception techniques. Embryos containing the wrong number of chromosomes (aneuploidy) may fail to implant in the uterus, miscarry, or lead ...

journal_title：Seminars in reproductive medicine

authors： Fragouli E,Wells D

更新日期：2012-08-01 00:00:00

abstract：:Successful in utero stem cell transplantations with hematopoietic or other stem cells should represent a major step forward in the management of patients with congenital, hematological, metabolic, and immunological disorders. The possibility of performing cell transplantations with stem cells across histoincompatibili...

journal_title：Seminars in reproductive medicine

authors： Westgren M

更新日期：2006-11-01 00:00:00

abstract：:The United States Agency for International Development (USAID) estimates that there are 225 million women and girls with unmet contraceptive need yearly. Unmet need for contraception is defined as women who desire a delay in childbearing and are not using a modern method of contraception. It is projected that providin...

journal_title：Seminars in reproductive medicine

authors： Schivone GB,Blumenthal PD

更新日期：2016-05-01 00:00:00

abstract：:Obesity is a pandemic and is associated with multiple medical problems including subfertility. Male obesity has been associated with altered semen parameters and reproductive hormonal levels, including a reduced testosterone:estradiol (T:E₂) ratio. Treatment methods employed for obesity-related male subfertility inclu...

journal_title：Seminars in reproductive medicine

authors： Stephens SM,Polotsky AJ

更新日期：2013-07-01 00:00:00

abstract：:Obesity-related infertility is one of the most common problems of reproductive-age obese women who desire childbearing. The various types of bariatric surgeries have proved effective in controlling excessive weight gain, improving fertility, and preventing certain maternal and fetal complications in these women. This ...

journal_title：Seminars in reproductive medicine

authors： Tan O,Carr BR

更新日期：2012-12-01 00:00:00