Abstract:
:The hypothalamus-pituitary-gonadal (HPG) axis is the most critical modulator of reproductive function. Genetic or environmental insults to the HPG axis during developmental windows can persist into adulthood, and processes such as gonadal hormone synthesis, timing of puberty, and fertility can be affected. At the level of the hypothalamus, multiple regions develop at different times and are under the control of a concert of signaling pathways and transcription factors required for their patterning and maturation. In this review, we highlight factors and pathways involved in specification and ultimate differentiation of neuronal and other cellular subtypes of the hypothalamus contributing to the HPG axis. Specifically, we discuss development of the arcuate and anteroventral periventricular nuclei, as well as forebrain development as it relates to reproductive function. Precise control of kisspeptin and gonadotropin-releasing hormone neuron, as well as tanycyte, development is necessary for understanding and ultimately treating developmental disruptions resulting in infertility.
journal_name
Semin Reprod Medjournal_title
Seminars in reproductive medicineauthors
Biehl MJ,Raetzman LTdoi
10.1055/s-0037-1599083subject
Has Abstractpub_date
2017-03-01 00:00:00pages
121-129issue
2eissn
1526-8004issn
1526-4564journal_volume
35pub_type
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journal_title:Seminars in reproductive medicine
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journal_title:Seminars in reproductive medicine
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journal_title:Seminars in reproductive medicine
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journal_title:Seminars in reproductive medicine
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journal_title:Seminars in reproductive medicine
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journal_title:Seminars in reproductive medicine
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journal_title:Seminars in reproductive medicine
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pub_type: 杂志文章,评审
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journal_title:Seminars in reproductive medicine
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pub_type: 历史文章,杂志文章,评审
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
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journal_title:Seminars in reproductive medicine
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pub_type: 杂志文章,评审
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journal_title:Seminars in reproductive medicine
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
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更新日期:2009-09-01 00:00:00
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journal_title:Seminars in reproductive medicine
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journal_title:Seminars in reproductive medicine
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
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