Medical therapy of endometriosis.

abstract：:Subclinical hypothyroidism has been found to be associated with adverse reproductive outcomes, such as infertility, miscarriage, preterm birth, and complications of pregnancy. Multiple studies have investigated the relationships between thyroid function, thyroid antibodies, fertility, and pregnancy. Thyroid autoimmuni...

journal_title：Seminars in reproductive medicine

authors： Seungdamrong A

更新日期：2016-11-01 00:00:00

abstract：:The hypothalamus-pituitary-gonadal (HPG) axis is the most critical modulator of reproductive function. Genetic or environmental insults to the HPG axis during developmental windows can persist into adulthood, and processes such as gonadal hormone synthesis, timing of puberty, and fertility can be affected. At the leve...

journal_title：Seminars in reproductive medicine

authors： Biehl MJ,Raetzman LT

更新日期：2017-03-01 00:00:00

abstract：:HOX genes, encoding homeodomain transcription factors, are dynamically expressed in endometrium, where they are necessary for endometrial growth, differentiation, and implantation. In human endometrium, the expression of HOXA10 and HOXA11 is driven by sex steroids, with peak expression occurring at time of implantatio...

journal_title：Seminars in reproductive medicine

authors： Cakmak H,Taylor HS

更新日期：2010-01-01 00:00:00

abstract：:Pelvic pain, acute or chronic, accounts for more than 10% of referrals to gynecologists. Pain accounts for more than 40% of gynecologic diagnostic laparoscopies. Predicting operative findings is critical in planning surgical interventions, as well as preoperative and postoperative medical therapy. Ultrasound is useful...

journal_title：Seminars in reproductive medicine

authors： Shwayder JM

更新日期：2008-05-01 00:00:00

abstract：:This study reviews systematically the effectiveness of management strategies for carriers of a reciprocal translocation involving two chromosomes, ascertained on the basis of recurrent pregnancy loss. Subsequent pregnancy outcomes were tabulated based on whether management was medical or involved in vitro fertilizatio...

journal_title：Seminars in reproductive medicine

authors： Hirshfeld-Cytron J,Sugiura-Ogasawara M,Stephenson MD

更新日期：2011-11-01 00:00:00

abstract：:Trophoblast cells of the murine placenta are derived from the trophectoderm (TE) cells of the preimplantation embryo. Establishment of the TE cell lineage is the result of a cell segregation event early in blastomere division. Models of cell lineage segregation suggest it is driven by the internalization of spatial in...

journal_title：Seminars in reproductive medicine

authors： Underhill LA,Robins JC

更新日期：2016-01-01 00:00:00

abstract：:Women with polycystic ovary syndrome (PCOS) most often seek treatment for reduction of hair growth and/or acne, restoration of menstrual cyclicity, and infertility. In addition, these patients are increasingly seeking advise and treatment for the metabolic abnormalities related to PCOS (e.g., insulin resistance and ty...

journal_title：Seminars in reproductive medicine

authors： Ehrmann DA,Rychlik D

更新日期：2003-08-01 00:00:00

abstract：:Premature ovarian failure (POF) is a disorder characterized by lack of ovulation and elevated levels of serum gonadotropins before the age of 40. The etiology of POF is not known but different environmental and genetic factors are involved, suggesting high heterogeneity of the disorder. The involvement of X-linked gen...

journal_title：Seminars in reproductive medicine

authors： Bione S,Toniolo D

更新日期：2000-01-01 00:00:00

abstract：:Identifying appropriate candidates for menopausal hormone therapy (HT) is challenging given the complex profile of risks and benefits associated with treatment. Most professional societies agree that HT should not be used for chronic disease prevention. Recent findings from the Women's Health Initiative and other rand...

journal_title：Seminars in reproductive medicine

authors： Wild RA,Manson JE

更新日期：2014-11-01 00:00:00

abstract：:Complementary therapies and medicines are a broad and diverse range of treatments, and are frequently used by women and their partners during the preconception period to assist with infertility, and to address pregnancy-related conditions. Despite frequent use, the evidence examining the efficacy, effectiveness, and s...

journal_title：Seminars in reproductive medicine

authors： Smith CA,Armour M,Ee C

更新日期：2016-03-01 00:00:00

abstract：:Androgen receptors are present in numerous tissues throughout the female body, and knowledge of the specific actions of androgens at different sites is increasing, along with the understanding of their contribution to various pathophysiological states. This article reviews the physiology of androgens (testosterone and...

journal_title：Seminars in reproductive medicine

authors： Davison SL,Bell R

更新日期：2006-04-01 00:00:00

abstract：:In non industrialized countries the incidence of heavy menstrual bleeding (HMB) appears to be similar to that of industrialized countries, although data is scanty. In low-resource settings, women with abnormal uterine bleeding (AUB) often delay seeking medical care because of cultural beliefs that a heavy red menstrua...

journal_title：Seminars in reproductive medicine

authors： Haththotuwa R,Goonewardene M,Desai S,Senanayake L,Tank J,Fraser IS

更新日期：2011-09-01 00:00:00

abstract：:Whereas the importance of close monitoring and tight glycemic control in diabetic pregnancies cannot be ignored, the growing body of knowledge surrounding the different effects of diabetes mellitus on the earliest stages of reproduction underscores the need for aggressive screening among reproductive-aged women at ris...

journal_title：Seminars in reproductive medicine

authors： Jungheim ES,Moley KH

更新日期：2008-03-01 00:00:00

abstract：:Research translation and evaluation are often underconsidered in research design and implementation thus limiting research benefit to the end user. In this article, we first describe a best practice approach to evaluation, for a center of research excellence in polycystic ovary syndrome. Within this, we outline a comp...

journal_title：Seminars in reproductive medicine

authors： Garad R,Kozica-Olenski S,Teede HJ

更新日期：2018-01-01 00:00:00

abstract：:Since 2004, assisted conception is encompassed by the European Directive on the Quality and Safety of Tissues and Cells (2004/23/EC). The aim of a standard for quality and safety is to minimize risks of errors, contamination, and accidents and to maximize efficiency of use. This article presents a case study of the im...

journal_title：Seminars in reproductive medicine

authors： Willemen D,D'Hooghe T,Knoops I,De Neubourg D,Spiessens C

更新日期：2012-06-01 00:00:00

abstract：:As fertility rates among women of advanced reproductive age have steadily increased, so has the utilization of fertility services. National health policies provide infertility treatment coverage in several developed countries; however, in the United States infertility treatment is largely privately funded, resulting i...

journal_title：Seminars in reproductive medicine

authors： Levens ED,Richter KS,Levy MJ

更新日期：2013-05-01 00:00:00

abstract：:Microfluidics is a young but established field that holds significant potential for scientific discovery. The utility of microfluidics can improve our knowledge of basic biology as well as expand our understanding in specialized areas such as assisted reproduction and stem cell developmental biology. This review descr...

journal_title：Seminars in reproductive medicine

authors： Smith GD,Swain JE,Bormann CL

更新日期：2011-01-01 00:00:00

abstract：:Despite the critical role the placenta plays in governing the outcome of pregnancy, a great deal remains to be learned about this transient organ. Several factors have contributed to our relative lack of knowledge. For example, most of the placenta's development, which precedes that of the embryo or fetus, occurs duri...

journal_title：Seminars in reproductive medicine

authors： Fisher SJ

更新日期：2000-01-01 00:00:00

abstract：:As sperm traverse the female tract from vagina to oocyte, they experience a steroid milieu, which due to transcriptional inactivity, they can only respond to via non-genomic signaling. This environment mediates events including capacitation, changes in motility patterns, chemotaxis, and acrosome reaction. Current know...

journal_title：Seminars in reproductive medicine

authors： Correia JN,Conner SJ,Kirkman-Brown JC

更新日期：2007-05-01 00:00:00

abstract：:Puberty is a fundamental developmental event in the lifespan of any individual, when sexual and somatic maturation is completed, and reproductive capacity is achieved. While the tempo of puberty is under strong genetic determination, it is also modulated by a wide array of internal and environmental cues, including, p...

journal_title：Seminars in reproductive medicine

authors： Barroso A,Roa J,Tena-Sempere M

更新日期：2019-07-01 00:00:00

abstract：:Chromosome abnormalities are extremely common in human oocytes and embryos and are associated with a variety of negative outcomes for both natural cycles and those using assisted conception techniques. Embryos containing the wrong number of chromosomes (aneuploidy) may fail to implant in the uterus, miscarry, or lead ...

journal_title：Seminars in reproductive medicine

authors： Fragouli E,Wells D

更新日期：2012-08-01 00:00:00

abstract：:Translocations involving the X and Y chromosomes are often associated with anomalies of gonadal development. Transfer of Yp sequences, including the testis-determining SRY gene, to the terminal portion of the short arm of the X chromosome is associated with 46,XX maleness and in rare cases 46,XX true hermaphroditism. ...

journal_title：Seminars in reproductive medicine

authors： McElreavey K,Cortes LS

更新日期：2001-06-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) has become increasingly common over recent years and is associated with reproductive features as well as cardiometabolic risk factors, including visceral obesity, dyslipidemia and impaired glucose homeostasis, and potentially cardiovascular disease. Emerging evidence suggests that thes...

journal_title：Seminars in reproductive medicine

authors： Shorakae S,Teede H,de Courten B,Lambert G,Boyle J,Moran LJ

更新日期：2015-07-01 00:00:00

abstract：:The discrepancy between estrogen's beneficial cardiovascular effects found in animal studies and observational studies in women compared with the recently published randomized clinical trials have stimulated a great deal of controversy. Possibilities for the discrepancy include the age of the women, number of years po...

journal_title：Seminars in reproductive medicine

authors： Wagner JD,Clarkson TB

更新日期：2005-05-01 00:00:00

abstract：:In this article the role of LH receptor gene mutations in patients with aberrant sex differentiation is discussed. In a dominant autosomal familial form of precocious puberty in boys (familial male-limited precocious puberty) LH receptor gene mutations have been identified. These single amino acid changes, mostly foun...

journal_title：Seminars in reproductive medicine

authors： Themmen AP,Verhoef-Post M

更新日期：2002-08-01 00:00:00

abstract：:During the menstrual cycle, human endometrium undergoes extensive cyclic morphologic and biochemical modifications in preparation for embryo implantation. These processes are highly regulated by ovarian steroids and various locally expressed gene products and involve inflammatory reaction, apoptosis, cell proliferatio...

journal_title：Seminars in reproductive medicine

authors： Pan Q,Chegini N

更新日期：2008-11-01 00:00:00

abstract：:There is increasing evidence that endometriosis is inherited as a complex genetic trait in which multiple genes conferring disease susceptibility interact with each other and the environment to produce the phenotype. Research groups worldwide are trying to identify such susceptibility genes through a "positional cloni...

journal_title：Seminars in reproductive medicine

authors： Kennedy S

更新日期：2003-05-01 00:00:00

abstract：:Male infertility is a condition that affects approximately 50% of infertile couples and about 30% of those couples have only male factor infertility identified. There has been speculation that male military service members may have an even greater lifetime prevalence of infertility as compared to the general populatio...

journal_title：Seminars in reproductive medicine

authors： Reed-Maldonado AB,Madden KC

更新日期：2019-01-01 00:00:00

abstract：:Most of the patients with 5α-RD 2 deficiency are reared in the female social sex due to their severely undervirilized external genitalia but ~60% who have not been submitted to orchiectomy in childhood undergo male social sex change at puberty. In our cohort of 30 cases from 18 families, all subjects were registered i...

journal_title：Seminars in reproductive medicine

authors： Costa EM,Domenice S,Sircili MH,Inacio M,Mendonca BB

更新日期：2012-10-01 00:00:00

abstract：:Aging has dramatic effects on the reproductive system in women. Undoubtedly, the most notable changes in the neuroendocrine axis arise from the loss of ovarian function, and thus, the loss of negative feedback on the hypothalamus and pituitary. Progressive decreases in inhibin B and inhibin A result in an early increa...

journal_title：Seminars in reproductive medicine

authors： Hall JE

更新日期：2007-09-01 00:00:00