Non-genomic steroid actions in human spermatozoa. "Persistent tickling from a laden environment".

abstract：:Male infertility is a condition that affects approximately 50% of infertile couples and about 30% of those couples have only male factor infertility identified. There has been speculation that male military service members may have an even greater lifetime prevalence of infertility as compared to the general populatio...

journal_title：Seminars in reproductive medicine

authors： Reed-Maldonado AB,Madden KC

更新日期：2019-01-01 00:00:00

abstract：:In vitro fertilization (IVF) with ovarian stimulation is an effective treatment for couples needing treatment with assisted reproductive technologies (ART) where polycystic ovary syndrome (PCOS) is coexisting. However, it is also associated with an increased risk of ovarian hyperstimulation syndrome. In vitro maturati...

journal_title：Seminars in reproductive medicine

authors： Reinblatt SL,Buckett W

更新日期：2008-01-01 00:00:00

abstract：:The reproductive organs in both males and females consist of gonads, internal ductal structures, and external genitalia. Normal sexual differentiation is dependent on the genetic sex determined by the presence or absence of the Y chromosome at fertilization. Testes develop under the influence of the Y chromosome and o...

journal_title：Seminars in reproductive medicine

authors： Gell JS

更新日期：2003-11-01 00:00:00

abstract：:There is increasing evidence that endometriosis is inherited as a complex genetic trait in which multiple genes conferring disease susceptibility interact with each other and the environment to produce the phenotype. Research groups worldwide are trying to identify such susceptibility genes through a "positional cloni...

journal_title：Seminars in reproductive medicine

authors： Kennedy S

更新日期：2003-05-01 00:00:00

abstract：:The United States Agency for International Development (USAID) estimates that there are 225 million women and girls with unmet contraceptive need yearly. Unmet need for contraception is defined as women who desire a delay in childbearing and are not using a modern method of contraception. It is projected that providin...

journal_title：Seminars in reproductive medicine

authors： Schivone GB,Blumenthal PD

更新日期：2016-05-01 00:00:00

abstract：:Couples experiencing recurrent pregnancy loss are often concerned that toxins within the environment have contributed to their reproductive difficulty. Questions posed by these couples to their health care providers are difficult to answer because scientifically accurate information regarding the reproductive impact o...

journal_title：Seminars in reproductive medicine

authors： Gardella JR,Hill JA 3rd

更新日期：2000-01-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) has become increasingly common over recent years and is associated with reproductive features as well as cardiometabolic risk factors, including visceral obesity, dyslipidemia and impaired glucose homeostasis, and potentially cardiovascular disease. Emerging evidence suggests that thes...

journal_title：Seminars in reproductive medicine

authors： Shorakae S,Teede H,de Courten B,Lambert G,Boyle J,Moran LJ

更新日期：2015-07-01 00:00:00

abstract：:Successful in utero stem cell transplantations with hematopoietic or other stem cells should represent a major step forward in the management of patients with congenital, hematological, metabolic, and immunological disorders. The possibility of performing cell transplantations with stem cells across histoincompatibili...

journal_title：Seminars in reproductive medicine

authors： Westgren M

更新日期：2006-11-01 00:00:00

abstract：:Anejaculation within the context of a male infertility evaluation can be a distressing condition for patients. A variety of causes for anejaculation have been identified, and although the condition cannot be reversed, in many cases a minimally invasive treatment is feasible, allowing the patient to pursue his desire f...

journal_title：Seminars in reproductive medicine

authors： Ohl DA,Quallich SA,Sønksen J,Brackett NL,Lynne CM

更新日期：2009-03-01 00:00:00

abstract：:Since 2004, assisted conception is encompassed by the European Directive on the Quality and Safety of Tissues and Cells (2004/23/EC). The aim of a standard for quality and safety is to minimize risks of errors, contamination, and accidents and to maximize efficiency of use. This article presents a case study of the im...

journal_title：Seminars in reproductive medicine

authors： Willemen D,D'Hooghe T,Knoops I,De Neubourg D,Spiessens C

更新日期：2012-06-01 00:00:00

abstract：:Women with polycystic ovary syndrome (PCOS) most often seek treatment for reduction of hair growth and/or acne, restoration of menstrual cyclicity, and infertility. In addition, these patients are increasingly seeking advise and treatment for the metabolic abnormalities related to PCOS (e.g., insulin resistance and ty...

journal_title：Seminars in reproductive medicine

authors： Ehrmann DA,Rychlik D

更新日期：2003-08-01 00:00:00

abstract：:Inhibin is a dimeric glycoprotein that suppresses follicle-stimulating hormone (FSH) secretion from the pituitary. Two bioactive forms of inhibin exist, inhibin A and B. The availability of specific immunoassays for each of the isoforms has enabled the study of the individual inhibins and their physiological roles. In...

journal_title：Seminars in reproductive medicine

authors： O'Connor AE,De Kretser DM

更新日期：2004-08-01 00:00:00

abstract：:There have been few formal studies of differences in the phenotype of PCOS among women of African-American ancestry. Generally, African-American women tend to have an adverse cardiovascular risk profile when compared with women of other racial groups. The metabolic syndrome is a clinical disorder that identifies indiv...

journal_title：Seminars in reproductive medicine

authors： Coney P,Ladson G,Sweet S,Legro RS

更新日期：2008-01-01 00:00:00

abstract：:Prior to the advent of modern minimally invasive surgery techniques, the primary surgical management of symptomatic leiomyomata for women desiring future fertility or uterine conservation was through laparotomy. Today, many cases of intramural and subserous leiomyomata are managed with laparoscopic myomectomy and sele...

journal_title：Seminars in reproductive medicine

authors： Advincula AP,Song A

更新日期：2004-05-01 00:00:00

abstract：:The birth of a child with ambiguous genitalia is a challenging and distressing event for the family and physician and one with life-long consequences. Most disorders of sexual differentiation (DSD) associated with ambiguous genitalia are the result either of inappropriate virilization of girls or incomplete virilizati...

journal_title：Seminars in reproductive medicine

authors： Wilson JD,Rivarola MA,Mendonca BB,Warne GL,Josso N,Drop SL,Grumbach MM

更新日期：2012-10-01 00:00:00

abstract：:Follicular rupture and the transformation of an estrogenic preovulatory follicle into a highly vascularized corpus luteum capable of producing large quantities of progesterone are required for the establishment of pregnancy. These processes are dependent upon the precise remodeling of the ovarian extracellular matrix ...

journal_title：Seminars in reproductive medicine

authors： Curry TE Jr,Smith MF

更新日期：2006-09-01 00:00:00

abstract：:The Wnt signaling cascade is critically important in stem cell biology, both in homeostatic maintenance and repair and regeneration of tissues and organs, through their respective somatic stem cells (SSCs). However, aberrant Wnt signaling is associated with a wide array of tumor types and Wnt signaling is important in...

journal_title：Seminars in reproductive medicine

authors： Kahn M

更新日期：2015-09-01 00:00:00

abstract：:Controlled ovarian stimulation (COS) is widely used in assisted reproduction techniques (ART). However, hormonal treatment induces endometrial alterations that may alter implantation rates compared with natural cycles. Endometrial alterations have been observed by histological and biochemical techniques. The recent de...

journal_title：Seminars in reproductive medicine

authors： Horcajadas JA,Díaz-Gimeno P,Pellicer A,Simón C

更新日期：2007-11-01 00:00:00

abstract：:Gonadotropin-releasing hormone agonist (GnRHa) administration for the induction of oocyte maturation during in vitro fertilization treatment is effective in the prevention of ovarian hyperstimulation syndrome (OHSS). However, some studies have reported a lower ongoing pregnancy rate after GnRHa trigger. The excellent ...

journal_title：Seminars in reproductive medicine

authors： Engmann L,Benadiva C

更新日期：2010-11-01 00:00:00

abstract：:Research translation and evaluation are often underconsidered in research design and implementation thus limiting research benefit to the end user. In this article, we first describe a best practice approach to evaluation, for a center of research excellence in polycystic ovary syndrome. Within this, we outline a comp...

journal_title：Seminars in reproductive medicine

authors： Garad R,Kozica-Olenski S,Teede HJ

更新日期：2018-01-01 00:00:00

abstract：:Most of the patients with 5α-RD 2 deficiency are reared in the female social sex due to their severely undervirilized external genitalia but ~60% who have not been submitted to orchiectomy in childhood undergo male social sex change at puberty. In our cohort of 30 cases from 18 families, all subjects were registered i...

journal_title：Seminars in reproductive medicine

authors： Costa EM,Domenice S,Sircili MH,Inacio M,Mendonca BB

更新日期：2012-10-01 00:00:00

abstract：:Endocrine disrupters are exogenous substances that cause adverse effects in the endocrine system. Sexual differentiation is regulated by reproductive hormones. Male differentiation is critically dependent on normal androgen action, which in turn depends on normal production of luteinizing hormone. Other essential horm...

journal_title：Seminars in reproductive medicine

authors： Toppari J

更新日期：2002-08-01 00:00:00

abstract：:During most of gestation, the fetal adrenal gland is almost solely dedicated to the production of dehydroepiandrosterone sulfate (DHEA-S). This specialized ability of the fetal adrenal is unique to primates and occurs because of a specialized fetal zone that composes the bulk of the fetal adrenal gland. Morphologicall...

journal_title：Seminars in reproductive medicine

authors： Rainey WE,Rehman KS,Carr BR

更新日期：2004-11-01 00:00:00

abstract：:In non industrialized countries the incidence of heavy menstrual bleeding (HMB) appears to be similar to that of industrialized countries, although data is scanty. In low-resource settings, women with abnormal uterine bleeding (AUB) often delay seeking medical care because of cultural beliefs that a heavy red menstrua...

journal_title：Seminars in reproductive medicine

authors： Haththotuwa R,Goonewardene M,Desai S,Senanayake L,Tank J,Fraser IS

更新日期：2011-09-01 00:00:00

abstract：:Endometriosis is a nonmalignant gynecologic disorder that can have a significant impact on a woman's quality of life with pelvic pain and possible lasting effects on one's fertility. Symptoms, when present, can be severe and affect many organ systems including the gastrointestinal and urinary systems. Other etiologies...

journal_title：Seminars in reproductive medicine

authors： Kim JH,Han E

更新日期：2018-03-01 00:00:00

abstract：:The implementation of suitable quality control (QC) is not only required for the accreditation of a human in vitro fertilization (IVF) laboratory, but is also fundamental to its success. Several assays have been employed to screen culture media and contact supplies. The suitability of one assay in particular, the mous...

journal_title：Seminars in reproductive medicine

authors： Gardner DK,Reed L,Linck D,Sheehan C,Lane M

更新日期：2005-11-01 00:00:00

abstract：:HOX genes, encoding homeodomain transcription factors, are dynamically expressed in endometrium, where they are necessary for endometrial growth, differentiation, and implantation. In human endometrium, the expression of HOXA10 and HOXA11 is driven by sex steroids, with peak expression occurring at time of implantatio...

journal_title：Seminars in reproductive medicine

authors： Cakmak H,Taylor HS

更新日期：2010-01-01 00:00:00

abstract：:Androgen receptors are present in numerous tissues throughout the female body, and knowledge of the specific actions of androgens at different sites is increasing, along with the understanding of their contribution to various pathophysiological states. This article reviews the physiology of androgens (testosterone and...

journal_title：Seminars in reproductive medicine

authors： Davison SL,Bell R

更新日期：2006-04-01 00:00:00

abstract：:Pregnancy results in major changes in the hypothalamo-pituitary-adrenal (HPA) axis, which in turn influence fetal growth and the timing of labor. From the beginning of the second trimester maternal cortisol secretion increases, and in late pregnancy the placenta, in large part mediated through corticotroph-releasing h...

journal_title：Seminars in reproductive medicine

authors： Trainer PJ

更新日期：2002-11-01 00:00:00

abstract：:In this article the role of LH receptor gene mutations in patients with aberrant sex differentiation is discussed. In a dominant autosomal familial form of precocious puberty in boys (familial male-limited precocious puberty) LH receptor gene mutations have been identified. These single amino acid changes, mostly foun...

journal_title：Seminars in reproductive medicine

authors： Themmen AP,Verhoef-Post M

更新日期：2002-08-01 00:00:00