Management of abnormal uterine bleeding in low- and high-resource settings: consideration of cultural issues.

Abstract:

:In non industrialized countries the incidence of heavy menstrual bleeding (HMB) appears to be similar to that of industrialized countries, although data is scanty. In low-resource settings, women with abnormal uterine bleeding (AUB) often delay seeking medical care because of cultural beliefs that a heavy red menstrual bleed is healthy. Efforts to modify cultural issues are being considered. A detailed history and a meticulous examination are the important foundations of a definitive diagnosis and management in low-resource settings but are subject to time constraints and skill levels of the small numbers of health professionals. Women's subjective assessment of blood loss should be combined, if possible, with a colorimetric hemoglobin assessment, if full blood count is not possible. Outpatient endometrial sampling, transvaginal sonography, and hysteroscopy are available in some non industrialized countries but not in the lowest resource settings. After exclusion of serious underlying pathology, hematinics should be commenced and antifibrinolytic or nonsteroidal anti-inflammatory drugs considered during menses to control the bleeding. Intrauterine or oral progestogens or the combined oral contraceptive are often the most cost-effective long-term medical treatments. When medical treatment is inappropriate or has failed, the surgical options available most often are myomectomy or hysterectomy. Hysteroscopic endometrial resection or newer endometrial ablation procedures are available in some centers. If hysterectomy is indicated the vaginal route is the most appropriate in most low-resource settings. In low-resource settings, lack of resources of all types can lead to empirical treatments or reliance on the unproven therapies of traditional healers. The shortage of human resources is often compounded by a limited availability of operative time. Governments and specialist medical organizations have rarely included attention to AUB and HMB in their health programs. Local guidelines and attention to training of doctors, midwives, and traditional health workers are critical for prevention and improvement in management of HMB and its consequences for iron deficiency anemia and postpartum hemorrhage, the major killer of young women in developing countries.

journal_name

Semin Reprod Med

authors

Haththotuwa R,Goonewardene M,Desai S,Senanayake L,Tank J,Fraser IS

doi

10.1055/s-0031-1287668

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

446-58

issue

5

eissn

1526-8004

issn

1526-4564

journal_volume

29

pub_type

杂志文章,评审
  • Epigenetic transgenerational effects of endocrine disruptors on male reproduction.

    abstract::Endocrine-disrupting chemicals generally function as steroid receptor signaling antagonists or agonists that influence development to promote adult-onset disease. Exposure to the endocrine disruptors during the initiation of male reproductive tract development interferes with the normal hormonal signaling and formatio...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0029-1237428

    authors: Guerrero-Bosagna CM,Skinner MK

    更新日期:2009-09-01 00:00:00

  • Infertility and the Military Male.

    abstract::Male infertility is a condition that affects approximately 50% of infertile couples and about 30% of those couples have only male factor infertility identified. There has been speculation that male military service members may have an even greater lifetime prevalence of infertility as compared to the general populatio...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0039-1694027

    authors: Reed-Maldonado AB,Madden KC

    更新日期:2019-01-01 00:00:00

  • MicroRNA signature and regulatory functions in the endometrium during normal and disease states.

    abstract::During the menstrual cycle, human endometrium undergoes extensive cyclic morphologic and biochemical modifications in preparation for embryo implantation. These processes are highly regulated by ovarian steroids and various locally expressed gene products and involve inflammatory reaction, apoptosis, cell proliferatio...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0028-1096128

    authors: Pan Q,Chegini N

    更新日期:2008-11-01 00:00:00

  • Microbiota and pelvic inflammatory disease.

    abstract::Female genital tract microbiota play a crucial role in maintaining health. Disequilibrium of the microbiota has been associated with increased risk of pelvic infections. In recent years, culture-independent molecular techniques have expanded understanding of the composition of genital microbiota and the dynamic nature...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0033-1361822

    authors: Sharma H,Tal R,Clark NA,Segars JH

    更新日期:2014-01-01 00:00:00

  • Environmental endocrine disrupters and disorders of sexual differentiation.

    abstract::Endocrine disrupters are exogenous substances that cause adverse effects in the endocrine system. Sexual differentiation is regulated by reproductive hormones. Male differentiation is critically dependent on normal androgen action, which in turn depends on normal production of luteinizing hormone. Other essential horm...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2002-35377

    authors: Toppari J

    更新日期:2002-08-01 00:00:00

  • Indications of intrauterine insemination for male and non-male factor infertility.

    abstract::Intrauterine insemination (IUI) is a widely used fertility treatment for couples with male and/or non-male factor infertility and is a relatively simple and inexpensive procedure. When used for unexplained infertility, IUI combined with ovarian stimulation increases the pregnancy rates, but evidence does not support t...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0034-1375183

    authors: Kim YJ,Park CW,Ku SY

    更新日期:2014-07-01 00:00:00

  • Uterine receptivity and the ramifications of ovarian stimulation on endometrial function.

    abstract::Controlled ovarian stimulation (COS) is widely used in assisted reproduction techniques (ART). However, hormonal treatment induces endometrial alterations that may alter implantation rates compared with natural cycles. Endometrial alterations have been observed by histological and biochemical techniques. The recent de...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2007-991043

    authors: Horcajadas JA,Díaz-Gimeno P,Pellicer A,Simón C

    更新日期:2007-11-01 00:00:00

  • Does the European Union Tissues and Cells Directive improve quality in the in vitro fertilization laboratory? A case study in a tertiary referral center.

    abstract::Since 2004, assisted conception is encompassed by the European Directive on the Quality and Safety of Tissues and Cells (2004/23/EC). The aim of a standard for quality and safety is to minimize risks of errors, contamination, and accidents and to maximize efficiency of use. This article presents a case study of the im...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章

    doi:10.1055/s-0032-1311521

    authors: Willemen D,D'Hooghe T,Knoops I,De Neubourg D,Spiessens C

    更新日期:2012-06-01 00:00:00

  • The impact of type 1 and type 2 diabetes mellitus on the oocyte and the preimplantation embryo.

    abstract::Whereas the importance of close monitoring and tight glycemic control in diabetic pregnancies cannot be ignored, the growing body of knowledge surrounding the different effects of diabetes mellitus on the earliest stages of reproduction underscores the need for aggressive screening among reproductive-aged women at ris...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1042957

    authors: Jungheim ES,Moley KH

    更新日期:2008-03-01 00:00:00

  • The Department of Defense Birth and Infant Health Research Program: Assessing the Reproductive Health of U.S. Active-Duty Women.

    abstract::As the percentage of women serving in the active-duty military continues to grow, and as their roles continue to expand, the importance of monitoring reproductive health in the military community increases. The Department of Defense Birth and Infant Health Research (BIHR) program conducts ongoing epidemiologic studies...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0039-1678751

    authors: Khodr ZG,Bukowinski AT,Hall C,Gumbs GR,Wells NY,Conlin AMS

    更新日期:2018-11-01 00:00:00

  • The history and principles of cryopreservation.

    abstract::The ability of glycerol to protect cells from freezing injury was discovered accidentally. The subsequent development of cryopreservation techniques has had a huge impact in many fields, most notably in reproductive medicine. Freezing injury has been shown to have two components, direct damage from the ice crystals an...

    journal_title:Seminars in reproductive medicine

    pub_type: 历史文章,杂志文章,评审

    doi:10.1055/s-2002-23515

    authors: Pegg DE

    更新日期:2002-02-01 00:00:00

  • Fertility preservation: definition, history, and prospect.

    abstract::Exposure to gonadotoxic agents for treating cancer and other diseases or postponement of maternity jeopardize the prospects of genetic parenthood and are major factors driving the development of fertility preservation technologies. Although its mainstays, cryopreservation and vitrification, have been adopted from infe...

    journal_title:Seminars in reproductive medicine

    pub_type: 历史文章,杂志文章,评审

    doi:10.1055/s-0029-1241051

    authors: Gosden RG

    更新日期:2009-11-01 00:00:00

  • Randomized clinical trials: the meeting place of medical practice and clinical research.

    abstract::Randomized clinical trials (RCTs) have been used to assess interventions affecting health since biblical times. They provide the most valid means of measuring the true effects of intervention compared with no treatment or placebo. Although they can also be used to assess the value of diagnostic tests, this article foc...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2003-39995

    authors: Hughes EG

    更新日期:2003-02-01 00:00:00

  • A new function for the LH/CG receptor: transcytosis of hormone across the endothelial barrier in target organs.

    abstract::Gonadotropins cross the vascular endothelial barrier to reach their target organs. Hormone concentrations in blood are very low and fluctuate rapidly to give sharp biological effects. Nonspecific transendothelial transport mechanisms are slow and markedly concentration dependent. There is thus a need for specific tran...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2001-13916

    authors: Ghinea N,Milgrom E

    更新日期:2001-01-01 00:00:00

  • Medical therapy of endometriosis.

    abstract::The medical treatment of endometriosis is a critical aspect of the therapeutic approach to this disease. Past methods have been based upon systemic hormonal alterations, resulting in suppression of this estrogen-responsive disorder. Treatments such as danazol, progestogens, oral contraceptives, GnRH-agonists, and gest...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2003-41327

    authors: Olive DL

    更新日期:2003-05-01 00:00:00

  • Infertility and the environment: the medical context.

    abstract::Approximately 10 to 15% of the population experiences infertility. Although 85 to 90% of couples or individuals who experience infertility have a diagnosis for their infertility, underlying causes of infertility rarely are found. Extensive literature reporting adverse effects of environmental contaminants on wildlife ...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2006-944418

    authors: Giudice LC

    更新日期:2006-07-01 00:00:00

  • Aneuploidy screening for embryo selection.

    abstract::Chromosome abnormalities are extremely common in human oocytes and embryos and are associated with a variety of negative outcomes for both natural cycles and those using assisted conception techniques. Embryos containing the wrong number of chromosomes (aneuploidy) may fail to implant in the uterus, miscarry, or lead ...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0032-1313908

    authors: Fragouli E,Wells D

    更新日期:2012-08-01 00:00:00

  • Reproductive performance after ectopic pregnancy.

    abstract::Reproductive performance may be an important variable in treatment selection for unruptured ectopic pregnancy. The impact of treatment choice on reproductive performance is not known. We searched the literature and then tabulated published case reports on laparoscopic salpingostomy, multiple-dose methotrexate, single-...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2007-970052

    authors: Buster JE,Krotz S

    更新日期:2007-03-01 00:00:00

  • Does polycystic ovary syndrome increase the disparity in metabolic syndrome and cardiovascular-related health for African-American women?

    abstract::There have been few formal studies of differences in the phenotype of PCOS among women of African-American ancestry. Generally, African-American women tend to have an adverse cardiovascular risk profile when compared with women of other racial groups. The metabolic syndrome is a clinical disorder that identifies indiv...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2007-992922

    authors: Coney P,Ladson G,Sweet S,Legro RS

    更新日期:2008-01-01 00:00:00

  • Anejaculation: an electrifying approach.

    abstract::Anejaculation within the context of a male infertility evaluation can be a distressing condition for patients. A variety of causes for anejaculation have been identified, and although the condition cannot be reversed, in many cases a minimally invasive treatment is feasible, allowing the patient to pursue his desire f...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0029-1202307

    authors: Ohl DA,Quallich SA,Sønksen J,Brackett NL,Lynne CM

    更新日期:2009-03-01 00:00:00

  • Tissue-specific regulation of genes by estrogen receptors.

    abstract::Estrogens are frequently used in reproductive medicine. The Women's Health Initiative trial found that the risks of menopausal hormone therapy (MHT) exceed the benefits. The estrogens in MHT, however, were introduced prior to our understanding of the mechanism of action of estrogens. Estrogen signaling is highly compl...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0031-1299593

    authors: Leitman DC,Paruthiyil S,Yuan C,Herber CB,Olshansky M,Tagliaferri M,Cohen I,Speed TP

    更新日期:2012-01-01 00:00:00

  • The Role of a Mitochondrial Progesterone Receptor (PR-M) in Progesterone Action.

    abstract::Historically, progesterone functions to regulate gene expression via two nuclear progesterone receptors (PR-B and PR-A). Yet, actions of progesterone independent of gene regulation have been observed for decades. These are based on progesterone induced cellular events that occur too rapidly to involve gene transcripti...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0035-1552583

    authors: Price TM,Dai Q

    更新日期:2015-05-01 00:00:00

  • The human fetal adrenal: making adrenal androgens for placental estrogens.

    abstract::During most of gestation, the fetal adrenal gland is almost solely dedicated to the production of dehydroepiandrosterone sulfate (DHEA-S). This specialized ability of the fetal adrenal is unique to primates and occurs because of a specialized fetal zone that composes the bulk of the fetal adrenal gland. Morphologicall...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2004-861549

    authors: Rainey WE,Rehman KS,Carr BR

    更新日期:2004-11-01 00:00:00

  • Somatic stem cells in the myometrium and in myomas.

    abstract::The human uterus mainly consists of two layers: an inner endometrium and an outer layer, the myometrium, made of smooth muscle. The uterus is characterized by its unique capacity for regeneration. This capacity permits cyclical regeneration and remodeling of the tissue over the course of a woman's reproductive life. D...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0032-1331801

    authors: Maruyama T,Ono M,Yoshimura Y

    更新日期:2013-01-01 00:00:00

  • Contraceptive vaginal rings.

    abstract::Contraceptive vaginal rings (CVRs) contain sex steroids that diffuse through a plastic polymer ring at a constant rate and are absorbed directly through the vaginal epithelium into the systemic circulation. This delivery system provides many advantages over oral contraceptives (OCs), including avoidance of the first-p...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2001-18646

    authors: Harwood B,Mishell DR Jr

    更新日期:2001-12-01 00:00:00

  • Environmental toxins associated with recurrent pregnancy loss.

    abstract::Couples experiencing recurrent pregnancy loss are often concerned that toxins within the environment have contributed to their reproductive difficulty. Questions posed by these couples to their health care providers are difficult to answer because scientifically accurate information regarding the reproductive impact o...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2000-13731

    authors: Gardella JR,Hill JA 3rd

    更新日期:2000-01-01 00:00:00

  • The Impact and Management of Subclinical Hypothyroidism for Improving Reproductive Outcomes such as Fertility and Miscarriage.

    abstract::Subclinical hypothyroidism has been found to be associated with adverse reproductive outcomes, such as infertility, miscarriage, preterm birth, and complications of pregnancy. Multiple studies have investigated the relationships between thyroid function, thyroid antibodies, fertility, and pregnancy. Thyroid autoimmuni...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0036-1593487

    authors: Seungdamrong A

    更新日期:2016-11-01 00:00:00

  • In vitro maturation of oocytes.

    abstract::In vitro maturation of oocytes is a safe and effective treatment offered in some fertility centers for assisted reproduction, where immature oocytes are retrieved from unstimulated ovaries. Therefore, the procedure avoids ovarian stimulation with expensive gonadotropins, side effects of the medications, and risks such...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2005-872452

    authors: Rao GD,Tan SL

    更新日期:2005-08-01 00:00:00

  • Embryo nutrition and energy metabolism and its relationship to embryo growth, differentiation, and viability.

    abstract::Over the past decade there has been a resurgence of interest in the culture media used in clinical in vitro fertilization. Unfortunately, during this time more confusion than consensus appears to have developed regarding the composition of these media. In order to facilitate a clearer understanding of this field, it i...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2000-12559

    authors: Gardner DK,Pool TB,Lane M

    更新日期:2000-01-01 00:00:00

  • Evaluation of a Center of Research Excellence in Polycystic Ovary Syndrome as a Large-Scale Collaborative Research Translation Initiative, Including Evaluating Translation of Guideline Impact.

    abstract::Research translation and evaluation are often underconsidered in research design and implementation thus limiting research benefit to the end user. In this article, we first describe a best practice approach to evaluation, for a center of research excellence in polycystic ovary syndrome. Within this, we outline a comp...

    journal_title:Seminars in reproductive medicine

    pub_type: 杂志文章

    doi:10.1055/s-0038-1667308

    authors: Garad R,Kozica-Olenski S,Teede HJ

    更新日期:2018-01-01 00:00:00