Abstract:
:In vitro maturation of oocytes is a safe and effective treatment offered in some fertility centers for assisted reproduction, where immature oocytes are retrieved from unstimulated ovaries. Therefore, the procedure avoids ovarian stimulation with expensive gonadotropins, side effects of the medications, and risks such as ovarian hyperstimulation syndrome. Added advantages are reduced frequency of monitoring scans and shorter treatment regimen compared with in vitro fertilization. The candidates initially considered were women with polycystic ovaries having multiple antral follicles, but the indications are widening to include women with primarily poor quality embryos in repeated cycles and poor responders to stimulation. The two new applications for in vitro maturation we are now successfully implementing at McGill Reproductive Center are for oocyte donors and for fertility preservation, especially in women with cancer who are undergoing gonadotoxic therapy. In young women without partners needing this treatment for fertility preservation, it is combined with vitrification of the oocytes. We have achieved a 38% clinical pregnancy rate per cycle in women having IVM for infertility treatment up to the age of 35 years, and 50% clinical pregnancy rate per cycle in recipients of IVM egg donation.
journal_name
Semin Reprod Medjournal_title
Seminars in reproductive medicineauthors
Rao GD,Tan SLdoi
10.1055/s-2005-872452keywords:
subject
Has Abstractpub_date
2005-08-01 00:00:00pages
242-7issue
3eissn
1526-8004issn
1526-4564journal_volume
23pub_type
杂志文章,评审abstract::Obesity is a pandemic and is associated with multiple medical problems including subfertility. Male obesity has been associated with altered semen parameters and reproductive hormonal levels, including a reduced testosterone:estradiol (T:E₂) ratio. Treatment methods employed for obesity-related male subfertility inclu...
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journal_title:Seminars in reproductive medicine
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journal_title:Seminars in reproductive medicine
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journal_title:Seminars in reproductive medicine
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journal_title:Seminars in reproductive medicine
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journal_title:Seminars in reproductive medicine
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journal_title:Seminars in reproductive medicine
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pub_type: 杂志文章,评审
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更新日期:2016-05-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
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更新日期:2004-02-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2000-12569
更新日期:2000-01-01 00:00:00
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2003-43305
更新日期:2003-08-01 00:00:00
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journal_title:Seminars in reproductive medicine
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journal_title:Seminars in reproductive medicine
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journal_title:Seminars in reproductive medicine
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journal_title:Seminars in reproductive medicine
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