Abstract:
:Follicular rupture and the transformation of an estrogenic preovulatory follicle into a highly vascularized corpus luteum capable of producing large quantities of progesterone are required for the establishment of pregnancy. These processes are dependent upon the precise remodeling of the ovarian extracellular matrix (ECM). Such remodeling occurs both at the level of synthesis and/or proteolytic degradation of ECM proteins. Enzymes known to have important roles in ovarian ECM remodeling include matrix metalloproteinases, plasminogen activators/plasmin, and ADAMTS ( ADisintegrin And Metalloproteinase with Thrombo Spondin-like motifs). Each of the preceding proteases has corresponding inhibitors capable of regulating proteolytic activity temporally and spatially. This review focuses on recent contributions to our understanding of ovarian ECM remodeling that have furthered our appreciation of the role of proteinases in ovulation and the differentiation of follicular cells into the luteal phenotype.
journal_name
Semin Reprod Medjournal_title
Seminars in reproductive medicineauthors
Curry TE Jr,Smith MFdoi
10.1055/s-2006-948552subject
Has Abstractpub_date
2006-09-01 00:00:00pages
228-41issue
4eissn
1526-8004issn
1526-4564journal_volume
24pub_type
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journal_title:Seminars in reproductive medicine
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journal_title:Seminars in reproductive medicine
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journal_title:Seminars in reproductive medicine
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pub_type: 历史文章,杂志文章,评审
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journal_title:Seminars in reproductive medicine
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
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journal_title:Seminars in reproductive medicine
pub_type: 杂志文章,评审
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journal_title:Seminars in reproductive medicine
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journal_title:Seminars in reproductive medicine
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journal_title:Seminars in reproductive medicine
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journal_title:Seminars in reproductive medicine
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journal_title:Seminars in reproductive medicine
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