Abstract:
:HIV is among the most generically variable of human pathogens. A comprehensive and detailed description of HIV strains in the pandemic is an important foundation for diagnosis, treatment, and prevention. The current sequence database for HIV includes almost 800 complete genome sequences, documenting HIV-1 groups M, O, and N, and HIV-2. Among HIV-1 group M strains, responsible for the vast majority of HIV infections worldwide, 743 sequences represent 9 genetic subtypes, 16 circulating recombinant forms (CRF) that are spreading in populations, and a variety of unique recombinant forms (URF), identified so far only from a single individual. The global distribution of HIV is complex and dynamic with regional epidemics harboring only a subset of the global diversity. HIV strains differ enormously in terms of global prevalence. Six strains account for the majority of HIV infections: HIV-1 subtypes A, B, C, D, and two of the CRF, CRF01-AE and CRF02_AG, respectively. Many of the known subtypes and recombinant forms are currently rare in the epidemic, but could spread more widely if favorable conditions arise. HIV-2 is largely restricted to West Africa at relatively low prevalence there. Groups O and N of HIV-1 are very rare in the pandemic. The goal of universal coverage of HIV-1 strains by diagnostic tests can be met by minimizing false negative test rates for the six globally prevalent HIV-1 group M strains and HIV-2, and by evaluating systematically coverage of rare subtypes and recombinant forms.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
McCutchan FEdoi
10.1002/jmv.20599subject
Has Abstractpub_date
2006-01-01 00:00:00pages
S7-S12eissn
0146-6615issn
1096-9071journal_volume
78 Suppl 1pub_type
杂志文章abstract::Human cytomegalovirus (HCMV) infection is an important risk factor for atherosclerosis (AS). Numerous studies have been conducted to analyze the association between HCMV infection and risk of AS, but no clear consensus has been reached. So the objective of this paper was aimed to demonstrate the relationship between H...
journal_title:Journal of medical virology
pub_type: 杂志文章,meta分析
doi:10.1002/jmv.24858
更新日期:2017-12-01 00:00:00
abstract::Cytomegalovirus (CMV) is the most common congenital infection in humans and a leading cause of sensorineural hearing loss. Ganciclovir (6 mg/kg twice daily for 42 days) has been shown to reduce hearing deterioration and is used in clinical practice. Vaccines and passive administration of antibody are being evaluated i...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24654
更新日期:2017-03-01 00:00:00
abstract::Although hepatitis E virus (HEV) infection is a zoonosis, there is, currently, no standardized assay for quantitatively measuring anti-HEV antibody levels in HEV animal reservoirs. In this study, anti-HEV antibody positive serum from a rabbit (RS26) was calibrated by dose-response parallel line assay using the World H...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24651
更新日期:2017-03-01 00:00:00
abstract::Little information about immunity to respiratory syncytial virus (RSV) and disease pathogenesis in elderly persons exists. Humoral immunity to RSV was assessed in 41 young, 56 healthy elderly, and 49 frail elderly adults by measuring baseline RSV specific IgG by enzyme immunoassay (EIA) and microneutralization assay (...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199910)59:2<221::aid-jmv16
更新日期:1999-10-01 00:00:00
abstract::The detection of hepatitis B virus (HBV) DNA plays a critical role in determining the level of viral replication in HBV-infected patients. However, how to select appropriate HBV DNA detection method, low-sensitivity (ls) and hypersensitivity (hs) remains unclear. In this study, hepatitis B surface antigen (HBsAg), hep...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25271
更新日期:2019-02-01 00:00:00
abstract::To study the association between hepatitis B and schistosomiasis, 1,234 Egyptian males, ages 18 to 24, were interviewed, examined, and tested for Schistosoma mansoni infection and HBsAg. Sera from 91 (7.4%) of the study subjects were positive for HBsAg, and S. mansoni was found in the stools of 26.3%. There was no cor...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890230203
更新日期:1987-10-01 00:00:00
abstract::Hepatitis E virus (HEV) infection is considered a neglected disease of major concern in developed countries. Clinically, HEV occurs as an acute and self-limited disease, though chronic cases mostly associated to HEV-3 are now being commonly reported in immunocompromised individuals and solid organ transplant recipient...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26231
更新日期:2020-06-27 00:00:00
abstract::The human papillomavirus (HPV) 16 genome has been studied extensively, although no study has focused on the E1 gene that is implicated in viral DNA replication. After analyzing the E1 region of HPV 16 genomes in 429 cervical samples, 11.2% were found to contain a 63 nucleotides duplication in this region. Sequence ana...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21304
更新日期:2008-12-01 00:00:00
abstract::To elucidate the role of host immune status in the evolution and complexity of hepatitis C virus (HCV) quasispecies, three chronic HCV-infected patients who underwent bone marrow transplantation (BMT) were studied. The three transplanted patients' sera were sampled at pre-BMT, 3 months after BMT, and 12 months after B...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199906)58:2<132::aid-jmv6>
更新日期:1999-06-01 00:00:00
abstract::The prevalence of HHV-8 infection varies widely in South American populations, displaying geographical variations in its distribution. The heterogeneous genetic contributions provided by the transatlantic parental populations that modified the Native American genomes may explain this epidemiological observation. Aimin...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24656
更新日期:2017-03-01 00:00:00
abstract::KI is a novel polyomavirus identified in the respiratory secretions of children with acute respiratory symptoms. Whether this reflects a causal role of the virus in the human respiratory disease remains to be established. To investigate the presence of KIV in the respiratory tissue, we examined 20 fresh lung cancer sp...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21417
更新日期:2009-03-01 00:00:00
abstract::In vivo gene delivery using human adenovirus serotype 5 (AdV5) vectors is being explored for vaccination purposes. The presence of anti-AdV5 antibodies in human serum arising from natural exposure to AdV5 can interfere potentially with and compromise the efficacy of rAdV5-based vaccine vectors. In this report, a colle...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21721
更新日期:2010-03-01 00:00:00
abstract::Previous studies on patients who develop drug resistant HIV-1 variants have shown that continued use of failing regimens might provide clinical benefit. However, the effect of long-term exposure to drug resistant variants may lead to emergence of compensatory mutations that may jeopardize this effect. In this study, w...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20582
更新日期:2006-05-01 00:00:00
abstract::Hepatitis C Virus (HCV) genotype 4 predominates in Middle East and Central Africa countries. Recently, it has become also prevalent in Southern European countries where it is thought to have been introduced through immigration and the movement of intravenous drug users. In Italy, the prevalence of genotype 4 is partic...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23384
更新日期:2012-10-01 00:00:00
abstract::A random peptide library of heptamers displayed on the surface of M13 bacteriophage was used to identify specific epitopes of antibodies in pooled sera of swine naturally infected by Nipah virus. The selected heptapeptides were aligned with protein sequences of Nipah virus and several putative epitopes were identified...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20249
更新日期:2005-01-01 00:00:00
abstract::Hepatitis E virus (HEV), the sole member of the genus Hepevirus in the family of Hepeviridae, is the major cause of several outbreaks of waterborne hepatitis in tropical and subtropical countries and of sporadic cases of viral hepatitis in endemic and industrialized countries. Transmission of HEV occurs predominantly ...
journal_title:Journal of medical virology
pub_type: 杂志文章,评审
doi:10.1002/jmv.21116
更新日期:2008-04-01 00:00:00
abstract::The general aim was to investigate the burden of respiratory virus illness in a hospital emergency department, during two different epidemic seasons. Consecutive patients attending an emergency department during two study periods (February/March 2009 and 2010) were enrolled using broad inclusion criteria (fever/preced...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.22205
更新日期:2011-11-01 00:00:00
abstract::There is little information on JC virus (JCV) infection in renal transplant patients. A long-term prospective follow-up study was conducted to assess the incidence of JCV DNA in the blood of 103 adult renal transplant patients enrolled prospectively between 1 January and 31 December 2006. Patients were monitored until...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21951
更新日期:2011-01-01 00:00:00
abstract::Chikungunya fever a re-emerging infection with expanding geographical boundaries, can mimic symptoms of other infections like dengue, malaria which makes the definitive diagnosis of the infection important. The present study compares the utility of four laboratory diagnostic methods viz. IgM capture ELISA, an in house...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23406
更新日期:2012-11-01 00:00:00
abstract::The seroprevalences of hepatitis B virus (HBV) and hepatitis C virus (HCV) markers were evaluated in a random sample of 803 children attending school in Ashanti-Akim North district in Ghana in order to gain a better understanding of transmission patterns of these viruses, particularly horizontal transmission of HBV. T...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9071(199603)48:3<278::AID-JMV11
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Seasonal influenza is an annual occurrence that leads to large community outbreaks and increased hospitalisation. A number of studies have suggested that influenza A (FLUAV) is associated with increased rates of hospitalisation and mortality compared to influenza B (FLUBV). This study compared demographic an...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26600
更新日期:2020-10-15 00:00:00
abstract::Nucleotide sequences of the hypervariable region of hepatitis C virus genomes obtained from plasma change rapidly during the course of infection and are believed to play a part in immunological escape and consequently in the development of persistent infection. It is not known, however, whether these changes also occu...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890460103
更新日期:1995-05-01 00:00:00
abstract::In early 2008, a sudden increase in oseltamivir (Tamiflu)-resistant influenza A H1N1 viruses was reported from several European countries. This resistant virus has spread globally and accounted for more than 95% of H1N1 viruses isolated in the following influenza season. A continuous close monitoring on the prevalence...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21783
更新日期:2010-08-01 00:00:00
abstract::Type 1 immunity appears to be diminished in healthy Japanese carriers of human T-lymphotropic virus type I (HTLV-I), but type 2 status remains undetermined. To further examine the subclinical effect of HTLV-I on host immunity, we measured serum antibodies to the Epstein-Barr virus (EBV) in 415 healthy Japanese adults ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20633
更新日期:2006-06-01 00:00:00
abstract::Human bocavirus (HBOV) has been reported as a worldwide distributed respiratory pathogen. It has also been associated with encephalitis recently by detection of the virus in cerebrospinal fluid (CSF) of patients presented with encephalitis. This retrospective study aimed to present clinical features of HBOV infections...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24263
更新日期:2015-11-01 00:00:00
abstract::Some aspects of rotavirus humoral immunity were assessed on the basis of distinguishing serotype-specific specificities (VP4/VP7) by using rotavirus reassortants, human and animal strains in neutralization assays in serum samples obtained during the acute phase, and 1, 6 and 12 months after primary natural infection. ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890470418
更新日期:1995-12-01 00:00:00
abstract::To determine whether unconventional pathogens causing subacute spongiform encephalopathy may be present in blood products, a newly developed hepatitis B vaccine and a widely used blood product were injected into mice and rats. As only a few aged mice in the test and the control groups showed spongiform encephalopathic...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890160103
更新日期:1985-05-01 00:00:00
abstract::Acute gastroenteritis (AGE) is a common illness in both adults and children worldwide and is caused by several microorganisms including viruses, bacteria, and parasites. Rotavirus (RV), which is the main cause of AGE, can occur as a mixed infection with other viruses. The aim of this study is to assess the molecular e...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26013
更新日期:2020-05-15 00:00:00
abstract::Human herpes virus type 6 (HHV-6) infection is widespread in healthy individuals. The only definite disease association is with exanthem subitum in infants though the virus has been linked with a variety of other diseases including interstitial pneumonitis in bone marrow allograft recipients. In order to investigate t...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890410204
更新日期:1993-10-01 00:00:00
abstract::Immunoglobulin G (IgG) and M (IgM) antibodies against mumps virus were measured by an enzyme-linked immunosorbent assay (ELISA) in the serum and cerebrospinal fluid (CSF) specimens of patients with mumps meningitis. The CSF IgG antibodies correlated well with the respective antibody titers in serum. On the contrary, i...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890080406
更新日期:1981-01-01 00:00:00