Abstract：
:It is known that maternal deprivation induces hippocampal damage in the developing brains. In the present study, we examined the effects of melatonin on maternal deprivation-induced hippocampal damage both during and after stress-hyporesponsive period (SHRP). Hippocampal damage was examined by cresyl violet staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. The results showed that a single episode of maternal deprivation for 24 h at post-SHRP induced neuronal loss in hippocampus regions of the brain in the infant rats, while it did not influence hippocampal neurons in SHRP. Melatonin prevented maternal deprivation-induced hippocampal damage in the infant rats at post-SHRP. These results suggest that melatonin is a potentially beneficial agent to improve the neurobehavioral outcomes of maternal deprivation in later developmental period.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Tugyan K,Uysal N,Ozdemir D,Sonmez U,Pekcetin C,Erbil G,Sonmez Adoi
10.1016/j.neulet.2005.12.090keywords:
subject
Has Abstractpub_date
2006-05-01 00:00:00pages
145-50issue
1-2eissn
0304-3940issn
1872-7972pii
S0304-3940(05)01476-Xjournal_volume
398pub_type
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