Abstract:
:Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic neurons in the substantia nigra. Although the etiology of PD is incompletely understood, the recent discovery of genes associated with rare monogenic forms of the disease, together with earlier studies and new experimental animal models, has provided important and novel insight into the molecular pathways involved in disease pathogenesis. Increasing evidence indicates that deficits in mitochondrial function, oxidative and nitrosative stress, the accumulation of aberrant or misfolded proteins, and ubiquitin-proteasome system dysfunction may represent the principal molecular pathways or events that commonly underlie the pathogenesis of sporadic and familial forms of PD .
journal_name
Annu Rev Neuroscijournal_title
Annual review of neuroscienceauthors
Moore DJ,West AB,Dawson VL,Dawson TMdoi
10.1146/annurev.neuro.28.061604.135718keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
57-87eissn
0147-006Xissn
1545-4126journal_volume
28pub_type
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