Long-term depression in hippocampus.

Abstract:

:Long-term depression (LTD) is a lasting decrease in synaptic effectiveness that follows some types of electrical stimulation in the hippocampus. Two broad types of LTD may be distinguished. Heterosynaptic LTD can occur at synapses that are inactive, normally during high-frequency stimulation of a converging synaptic input. Homosynaptic LTD can occur at synapses that are activated, normally at low frequencies. Here we discuss the mechanisms of LTD and their possible relevance to hippocampal function.

journal_name

Annu Rev Neurosci

authors

Bear MF,Abraham WC

doi

10.1146/annurev.ne.19.030196.002253

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

437-62

eissn

0147-006X

issn

1545-4126

journal_volume

19

pub_type

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