Abstract:
:Medications, psychotherapy, and other treatments are effective for many patients with psychiatric disorders. However, with currently available interventions, a substantial number of patients experience incomplete resolution of symptoms, and relapse rates are high. In the search for better treatments, increasing interest has focused on focal neuromodulation. This focus has been driven by improved neuroanatomical models of mood, thought, and behavior regulation, as well as by more advanced strategies for directly and focally altering neural activity. Deep brain stimulation (DBS) is one of the most invasive focal neuromodulation techniques available; data have supported its safety and efficacy in a number of movement disorders. Investigators have produced preliminary data on the safety and efficacy of DBS for several psychiatric disorders, as well. In this review, we describe the development and justification for testing DBS for various psychiatric disorders, carefully consider the available clinical data, and briefly discuss potential mechanisms of action.
journal_name
Annu Rev Neuroscijournal_title
Annual review of neuroscienceauthors
Holtzheimer PE,Mayberg HSdoi
10.1146/annurev-neuro-061010-113638subject
Has Abstractpub_date
2011-01-01 00:00:00pages
289-307eissn
0147-006Xissn
1545-4126journal_volume
34pub_type
杂志文章,评审abstract::Prion diseases are transmissible neurodegenerative conditions that include Creutzfeldt-Jakob disease (CJD) in humans and bovine spongiform encephalopathy (BSE) and scrapie in animals. Prions appear to be composed principally or entirely of abnormal isoforms of a host-encoded glycoprotein, prion protein. Prion propagat...
journal_title:Annual review of neuroscience
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journal_title:Annual review of neuroscience
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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更新日期:2004-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.28.061604.135637
更新日期:2005-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.31.060407.125529
更新日期:2008-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.ne.19.030196.002253
更新日期:1996-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.29.051605.112839
更新日期:2006-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.21.1.347
更新日期:1998-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev-neuro-062012-170313
更新日期:2013-07-08 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev-neuro-071714-033954
更新日期:2016-07-08 00:00:00
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pub_type: 杂志文章
doi:10.1146/annurev-neuro-070918-050421
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.29.051605.112830
更新日期:2007-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.051508.135335
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journal_title:Annual review of neuroscience
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doi:10.1146/annurev-neuro-070918-050154
更新日期:2020-07-08 00:00:00
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journal_title:Annual review of neuroscience
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journal_title:Annual review of neuroscience
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doi:10.1146/annurev.neuro.26.010302.081210
更新日期:2003-01-01 00:00:00
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journal_title:Annual review of neuroscience
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更新日期:2011-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.29.051605.112933
更新日期:2006-01-01 00:00:00
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journal_title:Annual review of neuroscience
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更新日期:2017-07-25 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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更新日期:2002-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.21.1.25
更新日期:1998-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev-neuro-072116-031548
更新日期:2017-07-25 00:00:00