Abstract:
:Ten years of remarkable progress in understanding the fundamental biochemistry of Alzheimer's disease have been followed by ten years of remarkable and increasing clinical insight into the natural progression of the disorder. The concept of a long, intermediary, prodromal phase between the first appearance of amyloid plaques and tangles and the manifestation of dementia is now well established. The major challenge for the next decade is to chart the many cellular processes that underlie this phase and link the biochemical alterations to the clinical manifestation of Alzheimer's disease. We discuss here how genetics, new cell culture systems, and improved animal models will fuel this work. We anticipate that the resulting novel insights will provide a basis for further drug development for this terrible disease.
journal_name
Annu Rev Neuroscijournal_title
Annual review of neuroscienceauthors
Sala Frigerio C,De Strooper Bdoi
10.1146/annurev-neuro-070815-014015subject
Has Abstractpub_date
2016-07-08 00:00:00pages
57-79eissn
0147-006Xissn
1545-4126journal_volume
39pub_type
杂志文章,评审abstract::Spatial normalization--applying standardized coordinates as anatomical addresses within a reference space--was introduced to human neuroimaging research nearly 30 years ago. Over these three decades, an impressive series of methodological advances have adopted, extended, and popularized this standard. Collectively, th...
journal_title:Annual review of neuroscience
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journal_title:Annual review of neuroscience
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journal_title:Annual review of neuroscience
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journal_title:Annual review of neuroscience
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journal_title:Annual review of neuroscience
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journal_title:Annual review of neuroscience
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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journal_title:Annual review of neuroscience
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journal_title:Annual review of neuroscience
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journal_title:Annual review of neuroscience
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