Abstract:
:Activation of the hypothalamus-pituitary-adrenal axis plays a major role in the suppression of the immune system. We have investigated the effects of repetitive stress on Wistar rats infected with the Y strain of Trypanosoma cruzi and a control group that underwent stressor stimuli by exposure to ether vapor for one minute twice a day. Repetitive stress resulted in an elevated number of circulating parasites accompanies by deep tissue disorganization, and cardiac histopathological alterations. The infected and stressed group displayed a decrease in body weight, and an increased parasite burden in heart tissue, and adrenal glands. Histological analysis of the heart also showed a moderate to severe diffused mononuclear inflammatory process. These results suggest that repetitive stress could be considered an important factor during development of experimental Chagas' disease, enhancing pathogenesis through disturbance of the host's immune system.
journal_name
Exp Parasitoljournal_title
Experimental parasitologyauthors
Santos CD,Caldeira JC,Toldo MP,Prado JCdoi
10.1016/j.exppara.2005.03.009keywords:
subject
Has Abstractpub_date
2005-06-01 00:00:00pages
96-101issue
2eissn
0014-4894issn
1090-2449pii
S0014-4894(05)00084-6journal_volume
110pub_type
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journal_title:Experimental parasitology
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journal_title:Experimental parasitology
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abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
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journal_title:Experimental parasitology
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journal_title:Experimental parasitology
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journal_title:Experimental parasitology
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journal_title:Experimental parasitology
pub_type: 杂志文章
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journal_title:Experimental parasitology
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doi:10.1016/j.exppara.2010.11.002
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journal_title:Experimental parasitology
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journal_title:Experimental parasitology
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journal_title:Experimental parasitology
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/j.exppara.2006.07.009
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/j.exppara.2010.08.003
更新日期:2011-01-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/0014-4894(89)90116-1
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1006/expr.1997.4159
更新日期:1997-07-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/j.exppara.2007.03.007
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journal_title:Experimental parasitology
pub_type: 杂志文章
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/0014-4894(88)90003-3
更新日期:1988-10-01 00:00:00
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journal_title:Experimental parasitology
pub_type: 杂志文章
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