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Tritrichomonas foetus: pathogenesis of acute infection in normal, estradiol-treated, and stressed mice.

Abstract：

:Environmental stress and endocrine control can affect pathogenesis of sexually transmitted diseases such as trichomoniasis. Acute Tritrichomonas foetus infection was compared in female BALB/c mice to infections in mice treated with high doses of estradiol or housed in constant bright illumination (stressed). In untreated mice, T. foetus readily colonized the reproductive tract, causing minimal epithelial damage and inflammation. Several fold increases of IFN-gamma, TNF-alpha, MCP-1, and IL-6 cytokines were detected after estradiol-treatment of mice, resulting in greatly enhanced inflammation and tissue damage throughout the reproductive tract. Interestingly, estradiol-treatment of mice resulted in reduced T. foetus colonization compared to untreated mice. Infection in stressed mice resulted in increased tissue damage, inflammation, and inflammatory cytokine expression, although parasite colonization within the reproductive tract was similar to that in untreated mice. These results indicate that either estradiol-treatment or stress result in pathogenesis often observed during severe disease. Alternatively, infection in non-treated mice results in chronic colonization, with little inflammation or pathology.

journal_name

Exp Parasitol

journal_title

Experimental parasitology

authors

Rutkowski MR,Harmsen AG

doi

10.1016/j.exppara.2006.07.009

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

143-59

issue

2

eissn

0014-4894

issn

1090-2449

pii

S0014-4894(06)00185-8

journal_volume

115

pub_type

杂志文章

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