Abstract：
:The mitochondrial ATP synthase is a membrane protein complex which couples the proton gradient across the mitochondrial inner membrane to the synthesis of ATP from ADP+Pi. The complex is composed of essential subunits for its motor functions and supernumerary subunits, the roles of which remain to be elucidated. Subunits g and A6L are supernumerary subunits, and the specific roles of these subunits are still matters of debate. To gain insight into the functions of these two subunits, we carried out the alignment and the homolog search of the protein sequences of the subunits and found the following features: Subunit g appears to have isoforms in animals, and the transmembrane domain of the animal subunit g contains a completely conserved acidic residue in the middle of a helix on the conserved side of the transmembrane helix. This finding implicates the conserved acidic residue as important for the function of subunit g. The alignment of A6L protein sequences shows a conserved aromatic residue at the N-terminal domain with which the N-terminal MPQL sequence comprises a unique MPQLX4Ar motif that can signify the protein A6L. The conserved aromatic residue may also be important for the function of A6L.
journal_name
J Bioenerg Biomembrjournal_title
Journal of bioenergetics and biomembranesauthors
Hong S,Pedersen PLdoi
10.1007/s10863-004-8998-ykeywords:
subject
Has Abstractpub_date
2004-12-01 00:00:00pages
515-23issue
6eissn
0145-479Xissn
1573-6881journal_volume
36pub_type
杂志文章abstract：:To discover the effect of tumor necrosis factor-alpha-induced protein 8-like 2 (TIPE2) on the oral tongue squamous cell carcinoma (OTSCC) via affecting FoxP3+ regulatory T (Treg) cells. Immunohistochemistry was conducted to examine TIPE2 and FoxP3 expressions in OTSCC tumor tissues and corresponding oral mucosa. Tca81...
journal_title：Journal of bioenergetics and biomembranes
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更新日期：2020-08-01 00:00:00
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journal_title：Journal of bioenergetics and biomembranes
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journal_title：Journal of bioenergetics and biomembranes
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更新日期：2021-02-01 00:00:00
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journal_title：Journal of bioenergetics and biomembranes
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journal_title：Journal of bioenergetics and biomembranes
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journal_title：Journal of bioenergetics and biomembranes
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journal_title：Journal of bioenergetics and biomembranes
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更新日期：2012-02-01 00:00:00
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journal_title：Journal of bioenergetics and biomembranes
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journal_title：Journal of bioenergetics and biomembranes
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doi：10.1007/BF00748766
更新日期：1980-12-01 00:00:00
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journal_title：Journal of bioenergetics and biomembranes
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doi：10.1007/BF00743069
更新日期：1982-12-01 00:00:00
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journal_title：Journal of bioenergetics and biomembranes
pub_type： 杂志文章,评审
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journal_title：Journal of bioenergetics and biomembranes
pub_type： 杂志文章
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更新日期：1988-12-01 00:00:00
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journal_title：Journal of bioenergetics and biomembranes
pub_type： 杂志文章
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更新日期：2008-06-01 00:00:00
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journal_title：Journal of bioenergetics and biomembranes
pub_type： 杂志文章
doi：10.1007/s10863-010-9289-4
更新日期：2010-06-01 00:00:00
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journal_title：Journal of bioenergetics and biomembranes
pub_type： 杂志文章
doi：10.1007/s10863-013-9519-7
更新日期：2013-10-01 00:00:00
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journal_title：Journal of bioenergetics and biomembranes
pub_type： 杂志文章
doi：10.1007/s10863-012-9431-6
更新日期：2012-04-01 00:00:00
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journal_title：Journal of bioenergetics and biomembranes
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更新日期：2017-02-01 00:00:00
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journal_title：Journal of bioenergetics and biomembranes
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journal_title：Journal of bioenergetics and biomembranes
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journal_title：Journal of bioenergetics and biomembranes
pub_type： 杂志文章,评审
doi：10.1007/BF00769638
更新日期：1988-06-01 00:00:00
abstract：:In the mitochondrial F(O)F(1) ATP-synthase/ATPase complex, subunits α and β are part of the extrinsic portion that catalyses ATP synthesis. Since there are no reports about genes and proteins from these subunits in crustaceans, we analyzed the cDNA sequences of both subunits in the whiteleg shrimp Litopenaeus vannamei...
journal_title：Journal of bioenergetics and biomembranes
pub_type： 杂志文章
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更新日期：2011-04-01 00:00:00
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journal_title：Journal of bioenergetics and biomembranes
pub_type： 杂志文章,评审
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更新日期：2011-02-01 00:00:00
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journal_title：Journal of bioenergetics and biomembranes
pub_type： 杂志文章,评审
doi：10.1007/s10863-012-9407-6
更新日期：2012-02-01 00:00:00
abstract：:Previous in vitro studies indicated that mutation of both K234 and K236 to arginine, glutamine, or glutamic acid impaired the ability of the voltage-dependent anion channel (VDAC1) to insert into the outer membrane of the mitochondria (Smith et al. 1995). These same mutants were expressed in a strain of Saccharomyces ...
journal_title：Journal of bioenergetics and biomembranes
pub_type： 杂志文章
doi：10.1023/a:1005451811802
更新日期：1999-04-01 00:00:00
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journal_title：Journal of bioenergetics and biomembranes
pub_type： 杂志文章,评审
doi：10.1007/s10863-018-9780-x
更新日期：2019-02-01 00:00:00
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journal_title：Journal of bioenergetics and biomembranes
pub_type： 杂志文章
doi：10.1007/s10863-020-09838-4
更新日期：2020-08-01 00:00:00
abstract：:This review is primarily focused on the contribution of our laboratory to study of the mitochondrial uncoupling UCPs. The initial stage was the description of a 32-kDa membranous protein specifically induced in brown adipose tissue mitochondria of cold-adapted rats. This protein was then shown by others to be responsi...
journal_title：Journal of bioenergetics and biomembranes
pub_type： 杂志文章,评审
doi：10.1023/a:1005488105076
更新日期：1999-10-01 00:00:00
abstract：:Cellular Ca2+ signals are crucial in the control of most physiological processes, cell injury and programmed cell death; mitochondria play a pivotal role in the regulation of such cytosolic Ca2+ ([Ca2+]c) signals. Mitochondria are endowed with multiple Ca2+ transport mechanisms by which they take up and release Ca2+ a...
journal_title：Journal of bioenergetics and biomembranes
pub_type： 杂志文章,评审
doi：10.1023/a:1005508311495
更新日期：2000-02-01 00:00:00
abstract：:Epilepsy is considered one of the most common neurological disorders worldwide. The burst firing neurons associated with prolonged epileptic discharges could lead to a large number of changes with events of cascades at the cellular level. From its role as the cellular powerhouse, mitochondria also play a crucial role ...
journal_title：Journal of bioenergetics and biomembranes
pub_type： 杂志文章,评审
doi：10.1007/s10863-010-9321-8
更新日期：2010-12-01 00:00:00
