Mitochondria in Ca2+ signaling and apoptosis.

abstract：:The human multidrug resistance protein, or P-glycoprotein (Pgp), exhibits a high-capacity drug-dependent ATP hydrolytic activity that is a direct reflection of its drug transport capability. This activity is readily measured in membranes isolated from cultured insect cells infected with a baculovirus carrying the huma...

journal_title：Journal of bioenergetics and biomembranes

authors： Scarborough GA

更新日期：1995-02-01 00:00:00

abstract：:The original version of this article unfortunately contained a mistake. The name of "Zohreh Noaparast" is now corrected in the author group of this article. ...

journal_title：Journal of bioenergetics and biomembranes

authors： Hosseinimehr SJ,Safavi Z,Farahani SK,Noaparast Z,Ghasemi A,Asgarian-Omran H

更新日期：2019-08-01 00:00:00

abstract：:Complete initial steady state kinetics of NADH-decylubiquinone (DQ) oxidoreductase reaction between pH 6.5 and 9.0 show an ordered sequential mechanism in which the order of substrate bindings and product releases is NADH-DQ-DQH2-NAD+. NADH binding to the free enzyme is accelerated by protonation of an amino acid (pos...

journal_title：Journal of bioenergetics and biomembranes

authors： Hano N,Nakashima Y,Shinzawa-Itoh K,Terada H,Yoshikawa S

更新日期：2003-10-01 00:00:00

abstract：:Caloric restriction (CR) is widely known to increase life span and resistance to different types of injuries in several organisms. We have previously shown that mitochondria from livers or brains of CR animals exhibit higher calcium uptake rates and lower sensitivity to calcium-induced mitochondrial permeability trans...

journal_title：Journal of bioenergetics and biomembranes

authors： Serna JDC,Caldeira da Silva CC,Kowaltowski AJ

更新日期：2020-08-01 00:00:00

abstract：:The transport systems of animal and human tissues for vitamin C are reviewed with respect to their properties. It emerges that pure diffusion plays only a very minor role while a variety of more or less specific transporters is found on cellular membranes. Although most tissues prefer the reduced ascorbate over the ox...

journal_title：Journal of bioenergetics and biomembranes

authors： Goldenberg H,Schweinzer E

更新日期：1994-08-01 00:00:00

abstract：:We studied the importance of respiratory fitness in S. cerevisiae lifespan, response to caloric restriction (CR) and mtDNA stability. Mutants harboring mtDNA instability and electron transport defects do not respond to CR, while tricarboxylic acid cycle mutants presented extended lifespans due to CR. Interestingly, mt...

journal_title：Journal of bioenergetics and biomembranes

authors： Tahara EB,Cezário K,Souza-Pinto NC,Barros MH,Kowaltowski AJ

更新日期：2011-10-01 00:00:00

abstract：:The inner membrane of yeast and mammalian mitochondria has been studied in situ with a patch clamp electrode. Anion channels were found in both cases, although their behavior and regulation are different. In mammalian mitochondria, the principal channel is of around 100 pS conductance and opens mainly under depolarize...

journal_title：Journal of bioenergetics and biomembranes

authors： Ballarin C,Sorgato MC

更新日期：1996-04-01 00:00:00

abstract：:The midgut plasma membrane V-ATPase from larval Manduca sexta, the tobacco hornworm, is the sole energizer of any epithelial ion transport in this tissue and is responsible for the alkalinization of the gut lumen up to a pH of more than 11. This mini-review deals with those topics of research on this enzyme which may ...

journal_title：Journal of bioenergetics and biomembranes

authors： Wieczorek H,Grüber G,Harvey WR,Huss M,Merzendorfer H

更新日期：1999-02-01 00:00:00

abstract：:Thirteen different polypeptide subunits, each in one copy, five phosphatidyl ethanolamines and three phosphatidyl glycerols, two hemes A, three Cu ions, one Mg ion, and one Zn ion are detectable in the crystal structure of bovine heart cytochrome c oxidase in the fully oxidized form at 2.8 A resolution. A propionate o...

journal_title：Journal of bioenergetics and biomembranes

authors： Yoshikawa S,Shinzawa-Itoh K,Tsukihara T

更新日期：1998-02-01 00:00:00

abstract：:There has been increased interest in the use of naturally occurring compounds with chemopreventive and chemotherapeutic effects in the treatment of cancers. This review summarizes the most recent advances that provide new insights into the molecular mechanisms underlying the apoptotic potential of nutritional suppleme...

journal_title：Journal of bioenergetics and biomembranes

authors： Kwon KB,Park BH,Ryu DG

更新日期：2007-02-01 00:00:00

abstract：:Results are presented which, taken with evidence developed by others, suggest a general mechanism for the entry and binding of exogenous ligands (including O2) at the "binuclear site" (CuBFea3) of the heme-copper oxidases. The mechanism includes a "ligand shuttle" wherein the obligatory way station for incoming ligand...

journal_title：Journal of bioenergetics and biomembranes

authors： Woodruff WH

更新日期：1993-04-01 00:00:00

abstract：:F1-ATPases transiently entrap inhibitory MgADP in a catalytic site during turnover when noncatalytic sites are not saturated with ATP. An initial burst of ATP hydrolysis rapidly decelerates to a slow intermediate rate that gradually accelerates to a final steady-state rate. Transition from the intermediate to the fina...

journal_title：Journal of bioenergetics and biomembranes

authors： Allison WS,Jault JM,Dou C,Grodsky NB

更新日期：1996-10-01 00:00:00

abstract：:Subunit II of cytochrome c oxidase (Cox2) is usually encoded in the mitochondrial genome, synthesized in the organelle, inserted co-translationally into the inner mitochondrial membrane, and assembled into the respiratory complex. In chlorophycean algae however, the cox2 gene was split into the cox2a and cox2b genes, ...

journal_title：Journal of bioenergetics and biomembranes

authors： Jiménez-Suárez A,Vázquez-Acevedo M,Miranda-Astudillo H,González-Halphen D

更新日期：2017-12-01 00:00:00

abstract：:For the past seven years or so, much discussion and controversy in the field of human evolution has revolved around the application and interpretation of studies of human mitochondrial DNA variation, particularly the hypothesis that all mtDNA types in contemporary populations can be traced back to a single African anc...

journal_title：Journal of bioenergetics and biomembranes

authors： Stoneking M

更新日期：1994-06-01 00:00:00

abstract：:Soy isoflavones are diphenolic compounds that are frequently used for alternative treatment of ageing symptoms in both genders. They operate at principally two hierarchical levels of functional organization - cellular and molecular, while these 'types' of action appear to have indefinite borders. Soy isoflavone action...

journal_title：Journal of bioenergetics and biomembranes

authors： Ajdžanović VZ,Medigović IM,Pantelić JB,Milošević VLj

更新日期：2014-04-01 00:00:00

abstract：:NM23s (or NDP kinases) regulate a fascinating variety of cellular activities, including proliferation, development, and differentiation. All these processes are modulated by external stimuli, leading to the idea that this family of proteins modulates transmembrane signaling pathways. This review summarizes the evidenc...

journal_title：Journal of bioenergetics and biomembranes

authors： Otero AS

更新日期：2000-06-01 00:00:00

abstract：:Mitochondrial porin facilitates the diffusion of small hydrophilic molecules across the mitochondrial outer membrane. Despite low sequence similarity among porins from different species, a "glycine-leucine-lysine" (GLK) motif is conserved in mitochondrial and Neisseria porins. To investigate the possible roles of thes...

journal_title：Journal of bioenergetics and biomembranes

authors： Runke G,Maier E,O'Neil JD,Benz R,Court DA

更新日期：2000-12-01 00:00:00

abstract：:Epilepsy is considered one of the most common neurological disorders worldwide. The burst firing neurons associated with prolonged epileptic discharges could lead to a large number of changes with events of cascades at the cellular level. From its role as the cellular powerhouse, mitochondria also play a crucial role ...

journal_title：Journal of bioenergetics and biomembranes

authors： Chen SD,Chang AY,Chuang YC

更新日期：2010-12-01 00:00:00

abstract：:Mitochondrial impairment has been collecting more and more attention as a contributing factor to the etiology of Parkinson's disease. Above all, the NADH-quinone oxidoreductase, complex I, of the respiratory chain seems to be most culpable. Complex I dysfunction is translated to an increased production of reactive oxy...

journal_title：Journal of bioenergetics and biomembranes

authors： Marella M,Seo BB,Yagi T,Matsuno-Yagi A

更新日期：2009-12-01 00:00:00

abstract：:We summarize our current view of the reaction mechanism in F(1)-ATPase as it has emerged from experiment, theory, and computational studies over the last several years. ATP catalysis in the catalytic binding pockets of F(1) takes place without the release of any significant free energy and is efficiently driven by the...

journal_title：Journal of bioenergetics and biomembranes

authors： Dittrich M,Schulten K

更新日期：2005-12-01 00:00:00

abstract：:ATP1-111, a suppressor of the slow-growth phenotype of yme1Delta lacking mitochondrial DNA is due to the substitution of phenylalanine for valine at position 111 of the alpha-subunit of mitochondrial ATP synthase (Atp1p in yeast). The suppressing activity of ATP1-111 requires intact beta (Atp2p) and gamma (Atp3p) subu...

journal_title：Journal of bioenergetics and biomembranes

authors： Francis BR,White KH,Thorsness PE

更新日期：2007-04-01 00:00:00

abstract：:Precursor proteins destined for the mitochondrial matrix traverse inner and outer organelle membranes in an extended conformation. Translocation events are therefore integrally coupled to the processes of protein unfolding in the cytosol and protein refolding in the matrix. To successfully import proteins from the cyt...

journal_title：Journal of bioenergetics and biomembranes

authors： Martin J

更新日期：1997-02-01 00:00:00

abstract：:Methylmalonic acidemia is one of the most prevalent inherited metabolic disorders involving neurological deficits. In vitro experiments, animal model studies and tissue analyses from human patients suggest extensive impairment of mitochondrial energy metabolism in this disease. This review summarizes changes in mitoch...

journal_title：Journal of bioenergetics and biomembranes

authors： Melo DR,Kowaltowski AJ,Wajner M,Castilho RF

更新日期：2011-02-01 00:00:00

abstract：:Many oxidoreductases are constructed from (a) local sites of strongly coupled substrate-redox cofactor partners participating in exchange of electron pairs, (b) electron pair/single electron transducing redox centers, and (c) nonadiabatic, long-distance, single-electron tunneling between weakly coupled redox centers. ...

journal_title：Journal of bioenergetics and biomembranes

authors： Moser CC,Page CC,Farid R,Dutton PL

更新日期：1995-06-01 00:00:00

abstract：:Previous in vitro studies indicated that mutation of both K234 and K236 to arginine, glutamine, or glutamic acid impaired the ability of the voltage-dependent anion channel (VDAC1) to insert into the outer membrane of the mitochondria (Smith et al. 1995). These same mutants were expressed in a strain of Saccharomyces ...

journal_title：Journal of bioenergetics and biomembranes

authors： Angeles R,Devine J,Barton K,Smith M,McCauley R

更新日期：1999-04-01 00:00:00

abstract：:Phosphatase activity of a kidney (Na + K)-ATPase preparation was optimally active with Mg2+ plus K+. Mn2+ was less effective and Ca2+ could not substitute for Mg2+. However, adding Ca2+ with Mg2+ or substituting Mn2+ for Mg2+ activated it appreciably in the absence of added K+, and all three divalent cations decreased...

journal_title：Journal of bioenergetics and biomembranes

authors： Robinson JD

更新日期：1985-06-01 00:00:00

abstract：:Vicious cycle theories of aging and oxidative stress propose that ROS produced by the mitochondrial electron transport chain damage the mitochondria leading exponentially to more ROS production and mitochondrial damage. Although this theory is widely discussed in the field of research on aging and oxidative stress, th...

journal_title：Journal of bioenergetics and biomembranes

authors： Sanz A,Caro P,Gómez J,Barja G

更新日期：2006-04-01 00:00:00

abstract：:This paper presents results of experiments designed to further purify the membrane system involved in mitochondrial calcium transport. A partially purified extract, which transported calcium with a specific activity of 1194 nmol 45Ca2+/mg protein/5 min, was used to obtain mouse hyperimmune serum. This serum inhibited ...

journal_title：Journal of bioenergetics and biomembranes

authors： Zazueta C,Massò F,Paez A,Bravo C,Vega A,Montaño L,Vázquez M,Ramírez J,Chávez E

更新日期：1994-10-01 00:00:00

abstract：:The multi-subunit vacuolar-type H(+)-ATPase consists of a V(1) domain (A-H subunits) catalyzing ATP hydrolysis and a V(0) domain (a, c, c', c", d, e) responsible for H(+) translocation. The mammalian V(0) d subunit is one of the least-well characterized, and its function and position within the pump are still unclear....

journal_title：Journal of bioenergetics and biomembranes

authors： Smith AN,Francis RW,Sorrell SL,Karet FE

更新日期：2008-08-01 00:00:00

abstract：:Proton transport-coupled unisite catalysis was measured with the H(+)-ATPase from chloroplasts. The reaction was measured in the ATP hydrolysis direction under deenergized conditions and in the ATP synthesis direction under energized conditions. The equilibrium constant of the enzyme does not change upon energization,...

journal_title：Journal of bioenergetics and biomembranes

authors： Gräber P,Labahn A

更新日期：1992-10-01 00:00:00