Abstract：
:Caloric restriction (CR) is widely known to increase life span and resistance to different types of injuries in several organisms. We have previously shown that mitochondria from livers or brains of CR animals exhibit higher calcium uptake rates and lower sensitivity to calcium-induced mitochondrial permeability transition (mPT), an event related to the resilient phenotype exhibited by these organs. Given the importance of calcium in metabolic control and cell homeostasis, we aimed here to uncover possible changes in mitochondrial calcium handling, redox balance and bioenergetics in cardiac and skeletal muscle mitochondria in response to six months of CR. Unexpectedly, we found that CR does not alter the susceptibility to mPT in muscle (cardiac or skeletal), nor calcium uptake rates. Despite the lack in changes in calcium transport properties, CR consistently decreased respiration in the presence of ATP synthesis in heart and soleus muscle. In heart, such changes were accompanied by a decrease in respiration in the absence of ATP synthesis, lower maximal respiratory rates and a reduced rate of hydrogen peroxide release. Hydrogen peroxide release was unaltered by CR in skeletal muscle. No changes were observed in inner membrane potentials and respiratory control ratios. Together, these results highlight the tissue-specific bioenergetic and ion transport effects induced by CR, demonstrating that resilience against calcium-induced mPT is not present in all tissues.
journal_name
J Bioenerg Biomembrjournal_title
Journal of bioenergetics and biomembranesauthors
Serna JDC,Caldeira da Silva CC,Kowaltowski AJdoi
10.1007/s10863-020-09838-4subject
Has Abstractpub_date
2020-08-01 00:00:00pages
269-277issue
4eissn
0145-479Xissn
1573-6881pii
10.1007/s10863-020-09838-4journal_volume
52pub_type
杂志文章abstract：:Uncoupling proteins (UCPs) located in the inner mitochondrial membrane are involved in the regulation of energy balance. Thus far, 5 UCP isoforms have been identified, but controversies exist in the research focused on the function of the UCPs (except UCP1) in the pathogenesis of obesity. Because of the known cross-re...
journal_title：Journal of bioenergetics and biomembranes
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更新日期：2010-06-01 00:00:00
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journal_title：Journal of bioenergetics and biomembranes
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journal_title：Journal of bioenergetics and biomembranes
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journal_title：Journal of bioenergetics and biomembranes
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journal_title：Journal of bioenergetics and biomembranes
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journal_title：Journal of bioenergetics and biomembranes
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journal_title：Journal of bioenergetics and biomembranes
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journal_title：Journal of bioenergetics and biomembranes
pub_type： 杂志文章,评审
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journal_title：Journal of bioenergetics and biomembranes
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journal_title：Journal of bioenergetics and biomembranes
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journal_title：Journal of bioenergetics and biomembranes
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更新日期：1994-12-01 00:00:00
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journal_title：Journal of bioenergetics and biomembranes
pub_type： 杂志文章
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更新日期：2006-02-01 00:00:00
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journal_title：Journal of bioenergetics and biomembranes
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更新日期：2017-08-01 00:00:00
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journal_title：Journal of bioenergetics and biomembranes
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journal_title：Journal of bioenergetics and biomembranes
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doi：10.1023/a:1021985521748
更新日期：1998-08-01 00:00:00
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journal_title：Journal of bioenergetics and biomembranes
pub_type： 杂志文章,评审
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更新日期：2017-02-01 00:00:00
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journal_title：Journal of bioenergetics and biomembranes
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journal_title：Journal of bioenergetics and biomembranes
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journal_title：Journal of bioenergetics and biomembranes
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journal_title：Journal of bioenergetics and biomembranes
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journal_title：Journal of bioenergetics and biomembranes
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journal_title：Journal of bioenergetics and biomembranes
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journal_title：Journal of bioenergetics and biomembranes
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journal_title：Journal of bioenergetics and biomembranes
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journal_title：Journal of bioenergetics and biomembranes
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doi：10.1007/BF00762225
更新日期：1991-04-01 00:00:00
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journal_title：Journal of bioenergetics and biomembranes
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journal_title：Journal of bioenergetics and biomembranes
pub_type： 杂志文章
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更新日期：2018-10-01 00:00:00
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journal_title：Journal of bioenergetics and biomembranes
pub_type： 杂志文章,评审
doi：10.1007/s10863-006-9056-8
更新日期：2007-02-01 00:00:00
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journal_title：Journal of bioenergetics and biomembranes
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更新日期：2020-08-01 00:00:00
abstract：:The P515 absorbance change upon single-turnover light flashes has been studied in intact leaves and isolated chloroplasts from spinach. A comparative study of the effects of preillumination on the kinetics of the P515 response and on the activity of the chloroplast ATPase has been made. The slow component (reaction 2)...
journal_title：Journal of bioenergetics and biomembranes
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更新日期：1983-12-01 00:00:00
