From discovery of the CHOP axis and targeting ClpP to the identification of additional axes of the UPRmt driven by the estrogen receptor and SIRT3.

abstract：:Free radical production and leak of brain nonsynaptic mitochondria were higher with pyruvate/malate than with succinate in rats and pigeons. Rotenone, antimycin A, and myxothiazol maximally stimulated free radical production with pyruvate/malate but not with succinate. Simultaneous treatment with myxothiazol plus anti...

journal_title：Journal of bioenergetics and biomembranes

authors： Barja G,Herrero A

更新日期：1998-06-01 00:00:00

abstract：:The development of new anti-neoplastic drugs is a key issue for cancer chemotherapy due to the reality that, most likely, certain cancer cells are resistant to current chemotherapy. The past two decades have witnessed tremendous advances in our understanding of the pathogenesis of cancer. These advances have allowed i...

journal_title：Journal of bioenergetics and biomembranes

authors： de Pedro N,Cautain B,Melguizo A,Vicente F,Genilloud O,Peláez F,Tormo JR

更新日期：2013-02-01 00:00:00

abstract：:Recent progress regarding the structure of the Ca(2+)-translocating ATPase of sarcoplasmic reticulum in several conformational states, and a substantial accumulation of biochemical information about this and other P-type ATPases, have put everything in place for the final convergence of biochemistry and structure that...

journal_title：Journal of bioenergetics and biomembranes

authors： Scarborough GA

更新日期：2003-06-01 00:00:00

abstract：:Porin or voltage-dependent anion-selective channel (VDAC) is the main protein responsible for the high permeability of the outer mitochondrial membrane. The mitochondrial porin is mainly composed of sided beta-strands, in analogy with bacterial porin, whose structure has been resolved at 1.8 A resolution. In mitochond...

journal_title：Journal of bioenergetics and biomembranes

authors： De Pinto VD,Palmieri F

更新日期：1992-02-01 00:00:00

abstract：:3-Bromopyruvate (3BP) is an energy-depleting drug that inhibits Hexokinase II activity by alkylation during glycolysis, thereby suppressing the production of ATP and inducing cell death. As such, 3BP can potentially serve as an anti-tumorigenic agent. Our previous research showed that 3BP can induce apoptosis via AKT ...

journal_title：Journal of bioenergetics and biomembranes

authors： Sun Y,Liu Z,Zou X,Lan Y,Sun X,Wang X,Zhao S,Jiang C,Liu H

更新日期：2015-08-01 00:00:00

abstract：:NM23s (or NDP kinases) regulate a fascinating variety of cellular activities, including proliferation, development, and differentiation. All these processes are modulated by external stimuli, leading to the idea that this family of proteins modulates transmembrane signaling pathways. This review summarizes the evidenc...

journal_title：Journal of bioenergetics and biomembranes

authors： Otero AS

更新日期：2000-06-01 00:00:00

abstract：:The past 5 years has witnessed an advance in our understanding of alpha1G (Cav3.1), alpha1H (Cav3.2), and alpha11 (Car3.3), the pore-forming subunits of T-type or low-voltage-activated calcium channels (LVAs). LVAs differ in their localization and molecular, biophysical, and biochemical properties, but all conduct a t...

journal_title：Journal of bioenergetics and biomembranes

authors： Yunker AM,McEnery MW

更新日期：2003-12-01 00:00:00

abstract：:Proteins specifically involved in the biogenesis of respiratory complex I in eukaryotes have been characterized. The complex I intermediate associated proteins CIA30 and CIA84 are tightly bound to an assembly intermediate of the membrane arm. Like chaperones, they are involved in multiple rounds of membrane arm assemb...

journal_title：Journal of bioenergetics and biomembranes

authors： Schulte U

更新日期：2001-06-01 00:00:00

abstract：:Three classes of inner mitochondrial membrane (IMM) channel activities have been defined by direct measurement of conductance levels in membranes with patch clamp techniques in 150 mM KCl. The "107 pS activity" is slightly anion selective and voltage dependent (open with matrix positive potentials). "Multiple conducta...

journal_title：Journal of bioenergetics and biomembranes

authors： Kinnally KW,Antonenko YN,Zorov DB

更新日期：1992-02-01 00:00:00

abstract：:The protons excreted by plant cells may arise by two different mechanisms: (1) by the action of the plasma membrane H(+)-ATPase and (2) by plasma membrane redox reactions. The exact proportion from each source is not known, but the plasma membrane H(+)-ATPase is, by far, the major contributor to proton efflux. There i...

journal_title：Journal of bioenergetics and biomembranes

authors： Barr R

更新日期：1991-06-01 00:00:00

abstract：:Thirteen different polypeptide subunits, each in one copy, five phosphatidyl ethanolamines and three phosphatidyl glycerols, two hemes A, three Cu ions, one Mg ion, and one Zn ion are detectable in the crystal structure of bovine heart cytochrome c oxidase in the fully oxidized form at 2.8 A resolution. A propionate o...

journal_title：Journal of bioenergetics and biomembranes

authors： Yoshikawa S,Shinzawa-Itoh K,Tsukihara T

更新日期：1998-02-01 00:00:00

abstract：:In the present study we have observed a higher state of coupling in respiring mitochondria isolated from green as compared to red tomatoes (Lycopersicon esculentum, Mill.). Green tomato mitochondria produced a membrane potential (deltapsi) high enough to phosphorylate ADP, whereas in red tomato mitochondria, BSA and A...

journal_title：Journal of bioenergetics and biomembranes

authors： Costa AD,Nantes IL,Jezek P,Leite A,Arruda P,Vercesi AE

更新日期：1999-10-01 00:00:00

abstract：:Signal peptidases, the endoproteases that remove the amino-terminal signal sequence from many secretory proteins, have been isolated from various sources. Seven signal peptidases have been purified, two from E. coli, two from mammalian sources, and three from mitochondrial matrix. The mitochondrial enzymes are soluble...

journal_title：Journal of bioenergetics and biomembranes

authors： Dev IK,Ray PH

更新日期：1990-06-01 00:00:00

abstract：:Retinoic acid inhibits the reduction of diferric transferrin through the transplasma membrane electron transport system on fetal rat liver cells infected with a temperature-sensitive SV40 virus when the cells are in the nontransformed state cultured at 40 degrees C. When the cells are in the transformed state (grown a...

journal_title：Journal of bioenergetics and biomembranes

authors： Sun IL,Toole-Simms W,Crane FL,Morré DJ,Löw H,Chou JY

更新日期：1988-06-01 00:00:00

abstract：:Copper transporting P-type ATPases, designated ATP7A and ATP7B, play an essential role in mammalian copper balance. Impaired intestinal transport of copper, resulting from mutations in the ATP7A gene, lead to Menkes disease in humans. Defects in a similar gene, the copper transporting ATPase ATP7B, result in Wilson di...

journal_title：Journal of bioenergetics and biomembranes

authors： Cox DW,Moore SD

更新日期：2002-10-01 00:00:00

abstract：:In the mitochondrial F(O)F(1) ATP-synthase/ATPase complex, subunits α and β are part of the extrinsic portion that catalyses ATP synthesis. Since there are no reports about genes and proteins from these subunits in crustaceans, we analyzed the cDNA sequences of both subunits in the whiteleg shrimp Litopenaeus vannamei...

journal_title：Journal of bioenergetics and biomembranes

authors： Martinez-Cruz O,Garcia-Carreño F,Robles-Romo A,Varela-Romero A,Muhlia-Almazan A

更新日期：2011-04-01 00:00:00

abstract：:At present there is a poor understanding of the events that lead up to neuronal apoptosis that occurs in neurodegenerative diseases and following acute ischemic episodes. Apoptosis is critical for the elimination of unwanted neurons within the developing nervous system. The Bcl-2 family of proteins contains pro- and a...

journal_title：Journal of bioenergetics and biomembranes

authors： Ward MW,Kögel D,Prehn JH

更新日期：2004-08-01 00:00:00

abstract：:The importance of crucial nutrient factors like Phosphate (P) and their limited availability leads to variable fluctuations in fatty acid and phospholipid synthesis in the green alga. These fatty acids and phospholipids are an imperative byproduct of alga which used in biofuel production. The production of phospholipi...

journal_title：Journal of bioenergetics and biomembranes

authors： Qari HA,Oves M

更新日期：2020-02-01 00:00:00

abstract：:The mitochondrial ATP synthase is a membrane protein complex which couples the proton gradient across the mitochondrial inner membrane to the synthesis of ATP from ADP+Pi. The complex is composed of essential subunits for its motor functions and supernumerary subunits, the roles of which remain to be elucidated. Subun...

journal_title：Journal of bioenergetics and biomembranes

authors： Hong S,Pedersen PL

更新日期：2004-12-01 00:00:00

abstract：:Thylakoids are highly protein-enriched membranes that harbor a number of multicomponent photosynthetic complexes. Similarly to other biological membranes the protein constituents are heterogeneously distributed laterally in the plane of the membrane, however the specific segregation into stacked (grana patches) and un...

journal_title：Journal of bioenergetics and biomembranes

authors： Petrova N,Todinova S,Paunov M,Kovács L,Taneva S,Krumova S

更新日期：2018-12-01 00:00:00

abstract：:Research on VDAC has accelerated as evidence grows of its importance in mitochondrial function and in apoptosis. New investigators entering the field are often confounded by the VDAC literature and its many apparent conflicts and contradictions. This review is an effort to shed light on the situation and identify reli...

journal_title：Journal of bioenergetics and biomembranes

authors： Rostovtseva TK,Tan W,Colombini M

更新日期：2005-06-01 00:00:00

abstract：:The small alkylating molecule, 3-bromopyruvate (3BP), is a potent and specific anticancer agent. 3BP is different in its action from most currently available chemo-drugs. Thus, 3BP targets cancer cells' energy metabolism, both its high glycolysis ("Warburg Effect") and mitochondrial oxidative phosphorylation. This inh...

journal_title：Journal of bioenergetics and biomembranes

authors： Ko YH,Verhoeven HA,Lee MJ,Corbin DJ,Vogl TJ,Pedersen PL

更新日期：2012-02-01 00:00:00

abstract：:Patch-clamp studies of the yeast Schizosaccharomyces pombe reveal that the plasma membrane contains a voltage-gated channel mildly selective for potassium over sodium, lithium, and chloride. The channel exhibits several conductances with a maximum of 153 pS. The channel gates in the region of physiologically relevant ...

journal_title：Journal of bioenergetics and biomembranes

authors： Vacata V,Höfer M,Larsson HP,Lecar H

更新日期：1993-02-01 00:00:00

abstract：:Transformation of 3T3 cells by SV40 virus changes the properties of the transplasma membrane electron transport activity which can be assayed by reduction of external ferric salts. After 42 h of culture and before the growth rate is maximum, the transformed cells have a much slower rate of ferric reduction. The change...

journal_title：Journal of bioenergetics and biomembranes

authors： Löw H,Crane FL,Grebing C,Isaksson M,Lindgren A,Sun IL

更新日期：1991-12-01 00:00:00

abstract：:Yeasts capable of growing and surviving at high temperatures are regarded as thermotolerant. For appropriate functioning of cellular processes and cell survival, the maintenance of an optimal redox state is critical of reducing and oxidizing species. We studied mitochondrial functions of the thermotolerant Kluyveromyc...

journal_title：Journal of bioenergetics and biomembranes

authors： Mejía-Barajas JA,Martínez-Mora JA,Salgado-Garciglia R,Noriega-Cisneros R,Ortiz-Avila O,Cortés-Rojo C,Saavedra-Molina A

更新日期：2017-04-01 00:00:00

abstract：:We have studied the effect of general anesthetics on the mobility of two stearic acid spin labels (5-doxyl stearic acid and 16-doxyl stearic acid) in bovine heart mitochondria and in phospholipid vesicles made from either mitochondrial lipids or commercial soybean phospholipids. The general anesthetics used include no...

journal_title：Journal of bioenergetics and biomembranes

authors： Mazzanti L,Curatola G,Zolese G,Bertoli E,Lenaz G

更新日期：1979-04-01 00:00:00

abstract：:We have studied changes in plasma membrane NAD(P)H:quinone oxidoreductases of HL-60 cells under serum withdrawal conditions, as a model to analyze cell responses to oxidative stress. Highly enriched plasma membrane fractions were obtained from cell homogenates. A major part of NADH-quinone oxidoreductase in the plasma...

journal_title：Journal of bioenergetics and biomembranes

authors： Forthoffer N,Gómez-Díaz C,Bello RI,Burón MI,Martín SF,Rodríguez-Aguilera JC,Navas P,Villalba JM

更新日期：2002-06-01 00:00:00

abstract：:This introductory article and those that follow focus on the roles that mitochondria may have in cancer metastasis (spreading) that all too frequently leads to death of cancer patients. The history of cancer dates back in time to several thousand years BC and continues to this day. Although billions of dollars have be...

journal_title：Journal of bioenergetics and biomembranes

authors： Pedersen PL

更新日期：2012-12-01 00:00:00

abstract：:The 8-kDa subunit c of the E. coli F0 ATP-synthase proton channel was tested for Ca++ binding activity using a 45Ca++ ligand blot assay after transferring the protein from SDS-PAGE gels onto polyvinyl difluoride membranes. The purified subunit c binds 45Ca++ strongly with Ca++ binding properties very similar to those ...

journal_title：Journal of bioenergetics and biomembranes

authors： Zakharov SD,Li X,Red'ko TP,Dilley RA

更新日期：1996-12-01 00:00:00

abstract：:The electrolyte-pigment-metal system can be described as analogous to a photosensitive junction region. When the thickness of the pigment film is increased, the action spectra of the maximum short-circuit photo-current under continuous illumination differ from the absorption spectra both in direct illumination (pigmen...

journal_title：Journal of bioenergetics and biomembranes

authors： Villar JG

更新日期：1976-08-01 00:00:00