The MRP1-mediated effluxes of arsenic and antimony do not require arsenic-glutathione and antimony-glutathione complex formation.


:Arsenic trioxide is an effective treatment for acute promyelocytic leukemia, but resistance to metalloid salts is found in humans. Using atomic absorption spectroscopy, we have measured the rate of uptake of arsenic trioxide and of antimony tartrate in GLC4 and GLC4/ADR cells overexpressing MRP1 and the rate of their MRP1-mediated effluxes as a function of the intracellular GSH concentration. In sensitive cells, after 1 h, a pseudosteady state is reached where intra- and extracellular concentrations of metalloid are the same. This precludes the formation, at short term, of complexes between arsenic or antimony with GSH. In resistant cells reduced intracellular accumulation of arsenic (or antimony), reflecting an increased rate of arsenic (or antimony) efflux from the cells, is observed. No efflux of the metalloid is observed in GSH depleted cells. The two metalloids and GSH are pumped out by MRP1 with the same efficiency. Moreover for the three compounds 50% of the efflux is inhibited by 2 microM MK571. This led us to suggest that As- and Sb-containing species could be cotransported with GSH.


J Bioenerg Biomembr


Salerno M,Petroutsa M,Garnier-Suillerot A





Has Abstract


2002-04-01 00:00:00












  • Anion channels of the inner membrane of mammalian and yeast mitochondria.

    abstract::The inner membrane of yeast and mammalian mitochondria has been studied in situ with a patch clamp electrode. Anion channels were found in both cases, although their behavior and regulation are different. In mammalian mitochondria, the principal channel is of around 100 pS conductance and opens mainly under depolarize...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章,评审


    authors: Ballarin C,Sorgato MC

    更新日期:1996-04-01 00:00:00

  • Low-voltage-activated ("T-Type") calcium channels in review.

    abstract::The past 5 years has witnessed an advance in our understanding of alpha1G (Cav3.1), alpha1H (Cav3.2), and alpha11 (Car3.3), the pore-forming subunits of T-type or low-voltage-activated calcium channels (LVAs). LVAs differ in their localization and molecular, biophysical, and biochemical properties, but all conduct a t...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章,评审


    authors: Yunker AM,McEnery MW

    更新日期:2003-12-01 00:00:00

  • Electrical stimulation of the energy metabolism in yeast cells using a planar Ti-Au-electrode interface.

    abstract::We report on the influence of dielectric pulse injection on the energy metabolism of yeast cells with a planar interdigitated electrode interface. The energy metabolism was measured via NADH fluorescence. The application of dielectric pulses results in a distinct decrease of the fluorescence, indicating a response of ...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Reiher A,Warnke C,Radoch S,Witte H,Krtschil A,Mair T,Müller SC,Krost A

    更新日期:2006-04-01 00:00:00

  • Parkinson's disease and mitochondrial complex I: a perspective on the Ndi1 therapy.

    abstract::Mitochondrial impairment has been collecting more and more attention as a contributing factor to the etiology of Parkinson's disease. Above all, the NADH-quinone oxidoreductase, complex I, of the respiratory chain seems to be most culpable. Complex I dysfunction is translated to an increased production of reactive oxy...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章,评审


    authors: Marella M,Seo BB,Yagi T,Matsuno-Yagi A

    更新日期:2009-12-01 00:00:00

  • Nuclear magnetic resonance methods to characterize lipid-protein interactions at membrane surfaces.

    abstract::Specific molecular interactions that determine many of the functions of a biomembrane have a high probability of occurring at the surface of that membrane. However, unlike their hydrophobic core, the polar-apolar interface of biomembranes has been somewhat neglected experimentally. Reasons for this are that the chemic...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章,评审


    authors: Watts A

    更新日期:1987-12-01 00:00:00

  • Electron microscopic structural analysis of Photosystem I, Photosystem II, and the cytochrome b6/f complex from green plants and cyanobacteria.

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    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章,评审


    authors: Boekema EJ,Boonstra AF,Dekker JP,Rögner M

    更新日期:1994-02-01 00:00:00

  • Kinetic analysis of excitation-contraction coupling.

    abstract::Recent studies of isolated muscle membrane have enabled induction and monitoring of rapid Ca2+ release from sarcoplasmic reticulum (SR)5 in vitro by a variety of methods. On the other hand, various proteins that may be directly or indirectly involved in the Ca2+ release mechanism have begun to be unveiled. In this min...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章,评审


    authors: Ikemoto N,Ronjat M,Mészáros LG

    更新日期:1989-04-01 00:00:00

  • Nucleoside diphosphate kinases in mammalian signal transduction systems: recent development and perspective.

    abstract::The role of nucleoside diphosphate (NDP) kinase with special reference to mammalian signal transduction systems was described. The interaction between NDP kinases and G proteins was reevaluated in view of their protein structural information and its significance was extended further on the basis of recent findings obt...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章,评审


    authors: Kimura N,Shimada N,Ishijima Y,Fukuda M,Takagi Y,Ishikawa N

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  • In vitro lipid oxidation modifies proteins and functional properties of sarcoplasmic reticulum.

    abstract::Changes in protein and fatty acid compositions of flounder sarcoplasmic reticulum during NADH plus ascorbate-dependent lipid peroxidation in vitro were related to the ability of the sarcoplasmic reticulum to sequester Ca+2. Progressive accumulation of high-molecular-weight protein components occurred concomitantly wit...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Luo SW,Hultin HO

    更新日期:1986-08-01 00:00:00

  • Evaluation by steady-state enzyme kinetics of the role of tightly bound nucleotides during photophosphorylation.

    abstract::The ATP synthetase of chloroplast membranes binds ADP and ATP with high affinity, and the binding becomes quasi-irreversible under certain conditions. One explanation of the function of these nucleotides is that they are transiently tightly bound during ATP synthesis as part of the catalytic process, and that the rele...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


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    更新日期:1983-10-01 00:00:00

  • Zooming in on ATP hydrolysis in F1.

    abstract::We summarize our current view of the reaction mechanism in F(1)-ATPase as it has emerged from experiment, theory, and computational studies over the last several years. ATP catalysis in the catalytic binding pockets of F(1) takes place without the release of any significant free energy and is efficiently driven by the...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章,评审


    authors: Dittrich M,Schulten K

    更新日期:2005-12-01 00:00:00

  • Soy isoflavones and cellular mechanics.

    abstract::Soy isoflavones are diphenolic compounds that are frequently used for alternative treatment of ageing symptoms in both genders. They operate at principally two hierarchical levels of functional organization - cellular and molecular, while these 'types' of action appear to have indefinite borders. Soy isoflavone action...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章,评审


    authors: Ajdžanović VZ,Medigović IM,Pantelić JB,Milošević VLj

    更新日期:2014-04-01 00:00:00

  • Pores from mitochondrial outer membranes of yeast and a porin-deficient yeast mutant: a comparison.

    abstract::Reconstitution experiments were performed on lipid bilayer membranes in the presence of purified mitochondrial porin from yeast and of detergent-solubilized mitochondrial outer membranes of a porin-free yeast mutant. The addition of the porin resulted in a strong increase of the membrane conductance, which was caused ...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章,评审


    authors: Benz R,Schmid A,Dihanich M

    更新日期:1989-08-01 00:00:00

  • Mitochondria and FOXO3 in stem cell homeostasis, a window into hematopoietic stem cell fate determination.

    abstract::The production of all blood cells from hematopoietic stem cells (HSC) is highly sensitive to reactive oxygen species (ROS). Cumulating evidence suggests that mitochondria are critical for HSC fate determination. FOXO are known regulators of anti-oxidant response and key to the maintenance of HSC. Recent works indicate...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章,评审


    authors: Liang R,Ghaffari S

    更新日期:2017-08-01 00:00:00

  • Partial characterization of the plasma membrane ATPase from a rho0 petite strain of Saccharomyces cerevisiae.

    abstract::Crude membrane preparations of a rho0 mutant of Saccharomyces cerevisiae exhibit Mg2+-dependent ATPase activity. Over the optimal pH range, 5.0-6.75, the apparent Vmax of the enzyme equals 590 nmoles of ATP hydrolyzed per minute per milligram protein, with an apparent Km for ATP of 1.3 mM. ATP hydrolysis is insensitiv...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: McDonough JP,Jaynes PK,Mahler HR

    更新日期:1980-08-01 00:00:00

  • The use of amphipathic maleimides to study membrane-associated proteins.

    abstract::A series of amphiphilic polymethlyenecarboxymaleimides has been synthesized for use as sulfhydryl reagents applicable to membrane proteins. Physical properties of the compounds which are relevant to their proposed mode of action have been determined. By comparing rates of reaction in aqueous and aprotic solvents, the ...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Griffiths DG,Partis MD,Churchill P,Brenner SC,Fleischer S,Moore RJ,Beechey RB

    更新日期:1990-10-01 00:00:00

  • Interaction of horse cytochrome c with the photosynthetic reaction center of Rhodospirillum rubrum.

    abstract::Mitochondrial cytochrome c (horse), which is a very efficient electron donor to bacterial photosynthetic reaction centers in vitro, binds to the reaction center of Rhodospirillum rubrum with an approximate dissociation constant of 0.3-0.5 microM at pH 8.2 and low ionic strength. The binding site for the reaction cente...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Bosshard HR,Snozzi M,Bachofen R

    更新日期:1987-08-01 00:00:00

  • F1F0-ATP synthase complex interactions in vivo can occur in the absence of the dimer specific subunit e.

    abstract::Evidence suggests membrane bound F(1)F(0)-ATPase complexes form stable associations such that dimers can be retrieved from detergent lysates of mitochondria isolated from a range of sources including algae, higher plants, yeast and bovine heart, and plant chloroplasts. The physiological relevance of these interactions...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Gavin PD,Prescott M,Devenish RJ

    更新日期:2005-04-01 00:00:00

  • Carbohydrate restriction does not change mitochondrial free radical generation and oxidative DNA damage.

    abstract::Many previous investigations have consistently reported that caloric restriction (40%), which increases maximum longevity, decreases mitochondrial reactive species (ROS) generation and oxidative damage to mitochondrial DNA (mtDNA) in laboratory rodents. These decreases take place in rat liver after only seven weeks of...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Sanz A,Gómez J,Caro P,Barja G

    更新日期:2006-12-01 00:00:00

  • How do alterations in plant mitochondrial genomes disrupt pollen development?

    abstract::Cytoplasmic male sterility arises when mitochondrial activities are disrupted that are essential for pollen development. Rearrangements in the mitochondrial genome that create novel open reading frames are strongly correlated with CMS phenotypes in a number of systems. The morphological aberrations which indicate CMS-...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章,评审


    authors: Conley CA,Hanson MR

    更新日期:1995-08-01 00:00:00

  • Targeted degradation of ABC transporters in health and disease.

    abstract::ATP binding cassette (ABC) transporters comprise an extended protein family involved in the transport of a broad spectrum of solutes across membranes. They consist of a common architecture including two ATP-binding domains converting chemical energy into conformational changes and two transmembrane domains facilitatin...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章,评审


    authors: Nikles D,Tampé R

    更新日期:2007-12-01 00:00:00

  • Functional characterization of the conserved "GLK" motif in mitochondrial porin from Neurospora crassa.

    abstract::Mitochondrial porin facilitates the diffusion of small hydrophilic molecules across the mitochondrial outer membrane. Despite low sequence similarity among porins from different species, a "glycine-leucine-lysine" (GLK) motif is conserved in mitochondrial and Neisseria porins. To investigate the possible roles of thes...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Runke G,Maier E,O'Neil JD,Benz R,Court DA

    更新日期:2000-12-01 00:00:00

  • Mechanisms underlying 3-bromopyruvate-induced cell death in colon cancer.

    abstract::3-Bromopyruvate (3BP) is an energy-depleting drug that inhibits Hexokinase II activity by alkylation during glycolysis, thereby suppressing the production of ATP and inducing cell death. As such, 3BP can potentially serve as an anti-tumorigenic agent. Our previous research showed that 3BP can induce apoptosis via AKT ...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Sun Y,Liu Z,Zou X,Lan Y,Sun X,Wang X,Zhao S,Jiang C,Liu H

    更新日期:2015-08-01 00:00:00

  • The possible role of redox-associated protons in growth of plant cells.

    abstract::The protons excreted by plant cells may arise by two different mechanisms: (1) by the action of the plasma membrane H(+)-ATPase and (2) by plasma membrane redox reactions. The exact proportion from each source is not known, but the plasma membrane H(+)-ATPase is, by far, the major contributor to proton efflux. There i...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章,评审


    authors: Barr R

    更新日期:1991-06-01 00:00:00

  • Experimental production of "septa" and apparent subdivision of muscle mitochondria.

    abstract::The rapid formation (in less than 45 min) of internal septa and the apparent subdivision in situ of mitochondria for cardiac and skeletal muscle are described following a variety of experimental treatments. For example, the ionophore A23187, caffeine, DNP, ruthenium red, and the insecticide lindane have been applied t...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Duncan CJ,Greenaway HC,Publicover SJ,Rudge MF,Smith JL

    更新日期:1980-04-01 00:00:00

  • The response of plant mitochondria to media of high solute content.

    abstract::The state-3 rate of respiration of potato tuber mitochondria is inhibited by concentrations of KCl or NaCl above 125 mM, and by concentrations of sucrose, lactose, or maltose above 500 mM, but not at all by mannitol, glucose, glycine, or proline up to a concentration of 1500 mM in the medium. Mitochondria from caulifl...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Campbell LC,Raison JK,Brady CJ

    更新日期:1976-06-01 00:00:00

  • Membrane potential and delta pH dependency of reverse electron transport-associated hydrogen peroxide production in brain and heart mitochondria.

    abstract::Succinate-driven reverse electron transport (RET) is one of the main sources of mitochondrial reactive oxygen species (mtROS) in ischemia-reperfusion injury. RET is dependent on mitochondrial membrane potential (Δψm) and transmembrane pH difference (ΔpH), components of the proton motive force (pmf); a decrease in Δψm ...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Komlódi T,Geibl FF,Sassani M,Ambrus A,Tretter L

    更新日期:2018-10-01 00:00:00

  • Huntington's disease and mitochondrial alterations: emphasis on experimental models.

    abstract::Huntington's disease (HD) is an inheritable neurological disorder coursing with degeneration of basal ganglia and producing chorea and dementia. One common factor accounting for neurodegeneration in this disorder is mitochondrial deterioration at both morphologic and functional levels. The development of experimental ...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Pérez-De la Cruz V,Carrillo-Mora P,Santamaría A

    更新日期:2010-06-01 00:00:00

  • Inclusions in aged mitochondria.

    abstract::The formation of paracrystalline inclusions in mitochondria following postmortem aging in situ is further investigated. Inclusions are found to localize either in the mitochondrial intracristal space or between the inner and outer membrane. The greater majority of the inclusions are of the intracristal type. pH is not...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Cheah KS,Cheah AM

    更新日期:1977-04-01 00:00:00

  • Electron transport chain in a thermotolerant yeast.

    abstract::Yeasts capable of growing and surviving at high temperatures are regarded as thermotolerant. For appropriate functioning of cellular processes and cell survival, the maintenance of an optimal redox state is critical of reducing and oxidizing species. We studied mitochondrial functions of the thermotolerant Kluyveromyc...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Mejía-Barajas JA,Martínez-Mora JA,Salgado-Garciglia R,Noriega-Cisneros R,Ortiz-Avila O,Cortés-Rojo C,Saavedra-Molina A

    更新日期:2017-04-01 00:00:00