Evolutionary aspects of cytochrome c oxidase.


:The presence of additional subunits in cytochrome oxidase distinguish the multicellular eukaryotic enzyme from that of a simple unicellular bacterial enzyme. The number of these additional subunits increases with increasing evolutionary stage of the organism. Subunits I-III of the eukaryotic enzyme are related to the three bacterial subunits, and they are encoded on mitochondrial DNA. The additional subunits are nuclear encoded. Experimental evidences are presented here to indicate that the lower enzymatic activity of the mammalian enzyme is due to the presence of nuclear-coded subunits. Dissociation of some of the nuclear-coded subunits (e.g. VIa) by laurylmaltoside and anions increased the activity of the rat liver enzyme to a value similar to that of the bacterial enzyme. Further, it is shown that the intraliposomal nucleotides influence the kinetics of ferrocytochrome c oxidation by the reconstituted enzyme from bovine heart but not from P. denitrificans. The regulatory function attributed to the nuclear-coded subunits of mammalian cytochrome c oxidase is also demonstrated by the tissue-specific response of the reconstituted enzyme from bovine heart but not from bovine liver to intraliposomal ADP. These enzymes from bovine heart and liver differ in the amino acid sequences of subunits VIa, VIIa, and VIII. The results presented here are taken to indicate a regulation of cytochrome c oxidase activity by nuclear-coded subunits which act like receptors for allosteric effectors and influence the catalytic activity of the core enzyme via conformational changes.


J Bioenerg Biomembr


Kadenbach B,Stroh A,Hüther FJ,Reimann A,Steverding D





Has Abstract


1991-04-01 00:00:00












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    abstract::Mitochondria are both targets and sources of oxidative stress. This dual relationship is particularly evident in experimental paradigms modeling ischemic brain injury. One mitochondrial metabolic enzyme that is particularly sensitive to oxidative inactivation is pyruvate dehydrogenase. This reaction is extremely impor...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章,评审


    authors: Fiskum G,Rosenthal RE,Vereczki V,Martin E,Hoffman GE,Chinopoulos C,Kowaltowski A

    更新日期:2004-08-01 00:00:00

  • The renal type II Na+/phosphate cotransporter.

    abstract::A sodium-dependent phosphate transporter (type II Na/Pi-cotransporter) was isolated which is expressed in apical membranes of proximal tubules and exhibits transport characteristics similar as described for renal reabsorption of phosphate. Type II associated Na/Pi-cotransport is electrogenic and results obtained by el...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章,评审


    authors: Biber J,Murer H,Forster I

    更新日期:1998-04-01 00:00:00

  • Neuronal apoptosis: BH3-only proteins the real killers?

    abstract::At present there is a poor understanding of the events that lead up to neuronal apoptosis that occurs in neurodegenerative diseases and following acute ischemic episodes. Apoptosis is critical for the elimination of unwanted neurons within the developing nervous system. The Bcl-2 family of proteins contains pro- and a...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章,评审


    authors: Ward MW,Kögel D,Prehn JH

    更新日期:2004-08-01 00:00:00

  • ATP synthases--structure of the F1-moiety and its relationship to function and mechanism.

    abstract::A great deal of progress has been made in understanding both the structure and the mechanism of F1-ATPase. The primary structure is now fully known for at least five species. Sequence comparison between chloroplast, photobacteria, aerobic bacteria, and mitochondrial representatives allow us to infer more general funct...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章,评审


    authors: Ysern X,Amzel LM,Pedersen PL

    更新日期:1988-08-01 00:00:00

  • Signal peptidases and signal peptide hydrolases.

    abstract::Signal peptidases, the endoproteases that remove the amino-terminal signal sequence from many secretory proteins, have been isolated from various sources. Seven signal peptidases have been purified, two from E. coli, two from mammalian sources, and three from mitochondrial matrix. The mitochondrial enzymes are soluble...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章,评审


    authors: Dev IK,Ray PH

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    abstract::The term "direct-coupled" is considered in the context of redox-linked proton translocation mechanisms, and the origins of this concept, its philosophical implications, applications, and contributions to the development of bioenergetics, are discussed. ...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章,评审


    authors: West IC

    更新日期:1991-10-01 00:00:00

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    abstract::2-Arachidonoylglicerol (2-AG) is an endocannabinoid that mimics the pharmacological effects of Δ⁹ tetrahydrocannabinol, the psychoactive component of the plant Cannabis sativa. It is present in many mammalian tissues, such as brain, liver, spleen, heart and kidney, where it exerts different biological effects either r...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Zaccagnino P,D'Oria S,Romano LL,Di Venere A,Sardanelli AM,Lorusso M

    更新日期:2012-04-01 00:00:00

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    abstract::Transformation of 3T3 cells by SV40 virus changes the properties of the transplasma membrane electron transport activity which can be assayed by reduction of external ferric salts. After 42 h of culture and before the growth rate is maximum, the transformed cells have a much slower rate of ferric reduction. The change...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Löw H,Crane FL,Grebing C,Isaksson M,Lindgren A,Sun IL

    更新日期:1991-12-01 00:00:00

  • High-conductance calcium-activated potassium channels; structure, pharmacology, and function.

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    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章,评审


    authors: Kaczorowski GJ,Knaus HG,Leonard RJ,McManus OB,Garcia ML

    更新日期:1996-06-01 00:00:00

  • Cross regulation between mTOR signaling and O-GlcNAcylation.

    abstract::The hexosamine biosynthetic pathway (HBP) integrates glucose, amino acids, fatty acids and nucleotides metabolisms for uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) synthesis. UDP-GlcNAc is the nucleotide sugar donor for O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) processes. O-GlcNAc transferase (OGT...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Very N,Steenackers A,Dubuquoy C,Vermuse J,Dubuquoy L,Lefebvre T,El Yazidi-Belkoura I

    更新日期:2018-06-01 00:00:00

  • Cancer cell bioenergetics and pH regulation influence breast cancer cell resistance to paclitaxel and doxorubicin.

    abstract::The multidrug resistance (MDR) phenotype, frequently observed during cancer treatment, is often associated with drug efflux pump activity. However, many other factors are also known to be involved. Cancer cells often rely on aerobic glycolysis for energy production; this is known as the "Warburg effect" and is used as...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Tavares-Valente D,Baltazar F,Moreira R,Queirós O

    更新日期:2013-10-01 00:00:00

  • Structure, function and regulation of the tricarboxylate transport protein from rat liver mitochondria.

    abstract::Recent progress is summarized on the structure, function, and regulation of the tricarboxylate (i.e., citrate) transport protein (CTP) from the rat liver mitochondrial inner membrane. The transporter has been purified and its reconstituted function characterized. A cDNA clone encoding the CTP has been isolated and seq...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Kaplan RS,Mayor JA

    更新日期:1993-10-01 00:00:00

  • Localization at complex I and mechanism of the higher free radical production of brain nonsynaptic mitochondria in the short-lived rat than in the longevous pigeon.

    abstract::Free radical production and leak of brain nonsynaptic mitochondria were higher with pyruvate/malate than with succinate in rats and pigeons. Rotenone, antimycin A, and myxothiazol maximally stimulated free radical production with pyruvate/malate but not with succinate. Simultaneous treatment with myxothiazol plus anti...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Barja G,Herrero A

    更新日期:1998-06-01 00:00:00

  • Sulfite inhibits the F1F0-ATP synthase and activates the F1F0-ATPase of Paracoccus denitrificans.

    abstract::The F1F0 complex of Paracoccus denitrificans (PdF1F0) is the fastest ATP synthase but the slowest ATPase. Sulfite exerts maximal activation of the PdF1F0-ATPase (Pacheco-Moisés, F., García, J. J., Rodríguez-Zavala, J. S., and Moreno-Sánchez, R. (2000). Eur J. Biochem. 267, 993-1000) but its effect on the PdF1F0-ATP sy...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Pacheco-Moisés F,Minauro-Sanmiguel F,Bravo C,García JJ

    更新日期:2002-08-01 00:00:00

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    abstract::Protein phosphorylation is an important mechanism in the modulation of voltage-dependent ionic channels. In squid giant axons, the potassium delayed rectifier channel is modulated by an ATP-mediated phosphorylation mechanism, producing important changes in amplitude and kinetics of the outward current. The characteris...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章,评审


    authors: Perozo E,Bezanilla F

    更新日期:1991-08-01 00:00:00

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    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Baniene R,Trumbeckas D,Kincius M,Pauziene N,Raudone L,Jievaltas M,Trumbeckaite S

    更新日期:2016-02-01 00:00:00

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    abstract::Vacuolar H+ ATPases participate in renal hydrogen ion secretion in both the proximal and distal nephron. These plasma membrane forms of the vacuolar H+ ATPase are regulated physiologically to maintain the acid-base balance of the organism. Proton transporting renal cells have requirements for constitutive acidificatio...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章,评审


    authors: Gluck SL

    更新日期:1992-08-01 00:00:00

  • The energy-conserving and energy-dissipating processes in mitochondria isolated from wild type and nonripening tomato fruits during development on the plant.

    abstract::Bioenergetics of tomato (Lycopersicon esculentum) development on the plant was followed from the early growing stage to senescence in wild type (climacteric) and nonripening mutant (nor, non-climacteric) fruits. Fruit development was expressed in terms of evolution of chlorophyll a content allowing the assessment of a...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Almeida AM,Navet R,Jarmuszkiewicz W,Vercesi AE,Sluse-Goffart CM,Sluse FE

    更新日期:2002-12-01 00:00:00

  • Kinetics of light emission and oxygen consumption by bioluminescent bacteria.

    abstract::Oxygen plays a key role in bacterial bioluminescence. The simultaneous and continuous kinetics of oxygen consumption and light emission during a complete exhaustion of the exogenous oxygen present in a closed system has been investigated. The kinetics are performed with Vibrio fischeri, V. harveyi, and Photobacterium ...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Bourgois JJ,Sluse FE,Baguet F,Mallefet J

    更新日期:2001-08-01 00:00:00

  • Mitochondria in Ca2+ signaling and apoptosis.

    abstract::Cellular Ca2+ signals are crucial in the control of most physiological processes, cell injury and programmed cell death; mitochondria play a pivotal role in the regulation of such cytosolic Ca2+ ([Ca2+]c) signals. Mitochondria are endowed with multiple Ca2+ transport mechanisms by which they take up and release Ca2+ a...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章,评审


    authors: Smaili SS,Hsu YT,Youle RJ,Russell JT

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  • Function of FXYD proteins, regulators of Na, K-ATPase.

    abstract::In this short review, we summarize our work on the role of members of the FXYD protein family as tissue-specific modulators of Na, K-ATPase. FXYD1 or phospholemman, mainly expressed in heart and skeletal muscle increases the apparent affinity for intracellular Na(+) of Na, K-ATPase and may thus be important for approp...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章,评审


    authors: Geering K

    更新日期:2005-12-01 00:00:00

  • Fluorescent dyes as a reliable tool in P2X7 receptor-associated pore studies.

    abstract::Since the nineteenth century, a great amount of different biological structures and processes have been assessed by fluorescent dyes. Along with the uses of these compounds as vital and histological dyes, some fluorescent dyes have become valuable tools for the study of the pore phenomenon in plasma membranes. Some io...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Ferreira L,Pereira L,Faria R

    更新日期:2015-08-01 00:00:00

  • Coordination dynamics of heme-copper oxidases. The ligand shuttle and the control and coupling of electron transfer and proton translocation.

    abstract::Results are presented which, taken with evidence developed by others, suggest a general mechanism for the entry and binding of exogenous ligands (including O2) at the "binuclear site" (CuBFea3) of the heme-copper oxidases. The mechanism includes a "ligand shuttle" wherein the obligatory way station for incoming ligand...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章,评审


    authors: Woodruff WH

    更新日期:1993-04-01 00:00:00

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    abstract::Absorbance changes at 446 nm in purified cytochrome oxidase following flash photolysis of carboxy-oxidase poised in the mixed valance state at +220 mV show biphasic kinetics. One phase corresponds to CO recombination to ferrous cytochrome a3 with an energy of activation of 9 kcal/mol; the second phase is 3-5 times fas...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Harmon HJ

    更新日期:1988-12-01 00:00:00

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    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Nakamura Y,Tonomura Y

    更新日期:1982-12-01 00:00:00

  • Solution structure of subunit a, a₁₀₄₋₃₆₃, of the Saccharomyces cerevisiae V-ATPase and the importance of its C-terminus in structure formation.

    abstract::The 95 kDa subunit a of eukaryotic V-ATPases consists of a C-terminal, ion-translocating part and an N-terminal cytosolic domain. The latter's N-terminal domain (~40 kDa) is described to bind in an acidification-dependent manner with cytohesin-2 (ARNO), giving the V-ATPase the putative function as pH-sensing receptor....

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Dip PV,Saw WG,Roessle M,Marshansky V,Grüber G

    更新日期:2012-06-01 00:00:00

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    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: García Montes de Oca LY,Chagolla-López A,González de la Vara L,Cabellos-Avelar T,Gómez-Lojero C,Gutiérrez Cirlos EB

    更新日期:2012-08-01 00:00:00

  • The road to the crystal structure of the cytochrome bc1 complex from the anoxigenic, photosynthetic bacterium Rhodobacter sphaeroides.

    abstract::The advantages of using bacterial systems to study the mechanism and function of cytochrome bc (1) complexes do not extend readily to their structural investigations. High quality crystals of bacterial complexes have been difficult to obtain despite the enzymes' smaller sizes and simpler subunit compositions compared ...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Xia D,Esser L,Elberry M,Zhou F,Yu L,Yu CA

    更新日期:2008-10-01 00:00:00

  • Calcium binding to the subunit c of E. coli ATP-synthase and possible functional implications in energy coupling.

    abstract::The 8-kDa subunit c of the E. coli F0 ATP-synthase proton channel was tested for Ca++ binding activity using a 45Ca++ ligand blot assay after transferring the protein from SDS-PAGE gels onto polyvinyl difluoride membranes. The purified subunit c binds 45Ca++ strongly with Ca++ binding properties very similar to those ...

    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 杂志文章


    authors: Zakharov SD,Li X,Red'ko TP,Dilley RA

    更新日期:1996-12-01 00:00:00

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    journal_title:Journal of bioenergetics and biomembranes

    pub_type: 社论


    authors: Pedersen PL

    更新日期:2012-02-01 00:00:00