Mitochondrial energy metabolism in neurodegeneration associated with methylmalonic acidemia.

abstract：:First, halorhodopsin is capable of pumping protons after illumination with green and blue light in the same direction as chloride. Second, mutated bacteriorhodopsin where the proton acceptor Asp85 and the proton donor Asp96 are replaced by Asn showed proton pump activity after illumination with blue light in the same ...

journal_title：Journal of bioenergetics and biomembranes

authors： Oesterhelt D,Tittor J,Bamberg E

更新日期：1992-04-01 00:00:00

abstract：:We have studied the effect of general anesthetics on the mobility of two stearic acid spin labels (5-doxyl stearic acid and 16-doxyl stearic acid) in bovine heart mitochondria and in phospholipid vesicles made from either mitochondrial lipids or commercial soybean phospholipids. The general anesthetics used include no...

journal_title：Journal of bioenergetics and biomembranes

authors： Mazzanti L,Curatola G,Zolese G,Bertoli E,Lenaz G

更新日期：1979-04-01 00:00:00

abstract：:Members of the genus Methanosarcina are strictly anaerobic archaea that derive their metabolic energy from the conversion of a restricted number of substrates to methane. H2 + CO2 are converted to CH4 via the CO2-reducing pathway, while methanol and methylamines are metabolized by the methylotrophic pathway. Two novel...

journal_title：Journal of bioenergetics and biomembranes

authors： Deppenmeier U

更新日期：2004-02-01 00:00:00

abstract：:Forkhead box protein O6 (FOXO6) has been recently identified as a novel regulator of oxidative stress in multiple pathological processes. However, whether FOXO6 participates in the regulation of oxidative stress of myocardial infarction is unclear. The present study was performed to evaluate the potential role of FOXO...

journal_title：Journal of bioenergetics and biomembranes

authors： Jin A,Zhang Q,Li S,Li B

更新日期：2020-12-01 00:00:00

abstract：:The multidrug resistance (MDR) phenotype, frequently observed during cancer treatment, is often associated with drug efflux pump activity. However, many other factors are also known to be involved. Cancer cells often rely on aerobic glycolysis for energy production; this is known as the "Warburg effect" and is used as...

journal_title：Journal of bioenergetics and biomembranes

authors： Tavares-Valente D,Baltazar F,Moreira R,Queirós O

更新日期：2013-10-01 00:00:00

abstract：:Soy isoflavones are diphenolic compounds that are frequently used for alternative treatment of ageing symptoms in both genders. They operate at principally two hierarchical levels of functional organization - cellular and molecular, while these 'types' of action appear to have indefinite borders. Soy isoflavone action...

journal_title：Journal of bioenergetics and biomembranes

authors： Ajdžanović VZ,Medigović IM,Pantelić JB,Milošević VLj

更新日期：2014-04-01 00:00:00

abstract：:We summarize our current view of the reaction mechanism in F(1)-ATPase as it has emerged from experiment, theory, and computational studies over the last several years. ATP catalysis in the catalytic binding pockets of F(1) takes place without the release of any significant free energy and is efficiently driven by the...

journal_title：Journal of bioenergetics and biomembranes

authors： Dittrich M,Schulten K

更新日期：2005-12-01 00:00:00

abstract：:Complex I (NDH-1) translocates protons across the membrane using electron transfer energy. Two different coupling mechanisms are currently being discussed for complex I: direct (redox-driven) and indirect (conformation-driven). Semiquinone (SQ) intermediates are suggested to be key for the coupling mechanism. Recently...

journal_title：Journal of bioenergetics and biomembranes

authors： Nakamaru-Ogiso E,Narayanan M,Sakyiama JA

更新日期：2014-08-01 00:00:00

abstract：:Thirteen different polypeptide subunits, each in one copy, five phosphatidyl ethanolamines and three phosphatidyl glycerols, two hemes A, three Cu ions, one Mg ion, and one Zn ion are detectable in the crystal structure of bovine heart cytochrome c oxidase in the fully oxidized form at 2.8 A resolution. A propionate o...

journal_title：Journal of bioenergetics and biomembranes

authors： Yoshikawa S,Shinzawa-Itoh K,Tsukihara T

更新日期：1998-02-01 00:00:00

abstract：:The soxL gene from Sulfolobus acidocaldarius (DSM 639) encodes a Rieske iron-sulfur protein. In this study we report the identification of two open reading frames in its downstream region. The first one, named soxN, codes for a membrane protein bearing a resemblance to the b-type cytochromes of the cytochrome bc1 and ...

journal_title：Journal of bioenergetics and biomembranes

authors： Hiller A,Henninger T,Schäfer G,Schmidt CL

更新日期：2003-04-01 00:00:00

abstract：:Due to the high metabolic demands of the placental tissue during gestation, we decide to analyzed the mitochondrial bioenergetic functions in the human term placenta. Different mitochondrial morphological parameters, membrane potential and cardiolipin content were determined by flow cytometry. Oxygen uptake, hydrogen ...

journal_title：Journal of bioenergetics and biomembranes

authors： Bustamante J,Ramírez-Vélez R,Czerniczyniec A,Cicerchia D,Aguilar de Plata AC,Lores-Arnaiz S

更新日期：2014-12-01 00:00:00

abstract：:Yeasts capable of growing and surviving at high temperatures are regarded as thermotolerant. For appropriate functioning of cellular processes and cell survival, the maintenance of an optimal redox state is critical of reducing and oxidizing species. We studied mitochondrial functions of the thermotolerant Kluyveromyc...

journal_title：Journal of bioenergetics and biomembranes

authors： Mejía-Barajas JA,Martínez-Mora JA,Salgado-Garciglia R,Noriega-Cisneros R,Ortiz-Avila O,Cortés-Rojo C,Saavedra-Molina A

更新日期：2017-04-01 00:00:00

abstract：:The protons excreted by plant cells may arise by two different mechanisms: (1) by the action of the plasma membrane H(+)-ATPase and (2) by plasma membrane redox reactions. The exact proportion from each source is not known, but the plasma membrane H(+)-ATPase is, by far, the major contributor to proton efflux. There i...

journal_title：Journal of bioenergetics and biomembranes

authors： Barr R

更新日期：1991-06-01 00:00:00

abstract：:Huntington's disease (HD) is an inheritable neurological disorder coursing with degeneration of basal ganglia and producing chorea and dementia. One common factor accounting for neurodegeneration in this disorder is mitochondrial deterioration at both morphologic and functional levels. The development of experimental ...

journal_title：Journal of bioenergetics and biomembranes

authors： Pérez-De la Cruz V,Carrillo-Mora P,Santamaría A

更新日期：2010-06-01 00:00:00

abstract：:In the present study we have observed a higher state of coupling in respiring mitochondria isolated from green as compared to red tomatoes (Lycopersicon esculentum, Mill.). Green tomato mitochondria produced a membrane potential (deltapsi) high enough to phosphorylate ADP, whereas in red tomato mitochondria, BSA and A...

journal_title：Journal of bioenergetics and biomembranes

authors： Costa AD,Nantes IL,Jezek P,Leite A,Arruda P,Vercesi AE

更新日期：1999-10-01 00:00:00

abstract：:Two kinds of ATP binding sites were found on the ATPase molecule in deoxycholic acid-treated sarcoplasmic reticulum. One was the catalytic site (1 mol/mol active site) and its affinity was high. Upon addition of Ca2+, all the ATP bound to the catalytic site disappeared at 75 mM KCl, while a significant amount of ATP r...

journal_title：Journal of bioenergetics and biomembranes

authors： Nakamura Y,Tonomura Y

更新日期：1982-12-01 00:00:00

abstract：:Hundreds of proteins in the nervous system are modified by the monosaccharide O-GlcNAc. A single protein is often O-GlcNAcylated on several amino acids and the modification of a single site can play a crucial role for the function of the protein. Despite its complexity, only two enzymes add and remove O-GlcNAc from pr...

journal_title：Journal of bioenergetics and biomembranes

authors： Lagerlöf O

更新日期：2018-06-01 00:00:00

abstract：:Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) has been recently identified as a novel inhibitor of multiple tumors; however, its role in glioblastoma (GBM) has not been investigated. This study aimed to evaluate whether LHPP exerts a potential tumor-inhibiting role in GBM. Compared with tha...

journal_title：Journal of bioenergetics and biomembranes

authors： Li C,Yang J,Wang W,Li R

更新日期：2021-02-01 00:00:00

abstract：:Cytoplasmic organelles with an acidic luminal pH include vacuoles, coated vesicles, lysosomes, the Golgi apparatus, and synaptic vesicles. Acidic compartments are also known outside specialized cells such as osteoclasts. The unique acidic pH is formed by V-ATPase (Vacuolar type ATPase), other ion transporters, and the...

journal_title：Journal of bioenergetics and biomembranes

authors： Sun-Wada GH,Wada Y,Futai M

更新日期：2003-08-01 00:00:00

abstract：:The fungal plasma membrane contains a proton-translocating ATPase that is closely related, both structurally and functionally, to the [Na+, K+]-, [H+, K+]-, and [Ca2+]-ATPases of animal cells, the plasma-membrane [H+]-ATPase of higher plants, and several bacterial cation-transporting ATPases. This review summarizes cu...

journal_title：Journal of bioenergetics and biomembranes

authors： Nakamoto RK,Slayman CW

更新日期：1989-10-01 00:00:00

abstract：:Available data indicate that minocycline, an antibiotic of the tetracycline family, has cytoprotective properties due to a direct interaction with mitochondria. Yet, the data in the case of isolated mitochondria suggest discrepant or even detrimental effect(s) of the interaction. We have studied the cytoprotective act...

journal_title：Journal of bioenergetics and biomembranes

authors： Karachitos A,Jordan J,Kmita H

更新日期：2012-06-01 00:00:00

abstract：:There has been increased interest in the use of naturally occurring compounds with chemopreventive and chemotherapeutic effects in the treatment of cancers. This review summarizes the most recent advances that provide new insights into the molecular mechanisms underlying the apoptotic potential of nutritional suppleme...

journal_title：Journal of bioenergetics and biomembranes

authors： Kwon KB,Park BH,Ryu DG

更新日期：2007-02-01 00:00:00

abstract：:A study of NADH ferricyanide reductase activity in oriented vesicles or open ghosts of human and porcine erythrocytes shows that the dehydrogenase activity can have three types of orientation in the membrane. There is activity which responds only to acceptors and NADH exclusively on the inside face, or exclusively on ...

journal_title：Journal of bioenergetics and biomembranes

authors： Crane FL,Crane HE,Sun IL,MacKellar WC,Grebing C,Löw H

更新日期：1982-12-01 00:00:00

abstract：:The proton/hydroxide (H+/OH-) permeability of phospholipid bilayer membranes at neutral pH is at least five orders of magnitude higher than the alkali or halide ion permeability, but the mechanism(s) of H+/OH- transport are unknown. This review describes the characteristics of H+/OH- permeability and conductance throu...

journal_title：Journal of bioenergetics and biomembranes

authors： Gutknecht J

更新日期：1987-10-01 00:00:00

abstract：:P-glycoprotein (Pgp), the ATP-binding cassette (ABC) transporter, confers multidrug resistance to cancer cells by extruding cytotoxic natural product amphipathic drugs using the energy of ATP hydrolysis. Our studies are directed toward understanding the mechanism of action of Pgp and recent work deals with the assessm...

journal_title：Journal of bioenergetics and biomembranes

authors： Sauna ZE,Smith MM,Müller M,Kerr KM,Ambudkar SV

更新日期：2001-12-01 00:00:00

abstract：:The inner membrane of yeast and mammalian mitochondria has been studied in situ with a patch clamp electrode. Anion channels were found in both cases, although their behavior and regulation are different. In mammalian mitochondria, the principal channel is of around 100 pS conductance and opens mainly under depolarize...

journal_title：Journal of bioenergetics and biomembranes

authors： Ballarin C,Sorgato MC

更新日期：1996-04-01 00:00:00

abstract：:The state-3 rate of respiration of potato tuber mitochondria is inhibited by concentrations of KCl or NaCl above 125 mM, and by concentrations of sucrose, lactose, or maltose above 500 mM, but not at all by mannitol, glucose, glycine, or proline up to a concentration of 1500 mM in the medium. Mitochondria from caulifl...

journal_title：Journal of bioenergetics and biomembranes

authors： Campbell LC,Raison JK,Brady CJ

更新日期：1976-06-01 00:00:00

abstract：:Oxygen plays a key role in bacterial bioluminescence. The simultaneous and continuous kinetics of oxygen consumption and light emission during a complete exhaustion of the exogenous oxygen present in a closed system has been investigated. The kinetics are performed with Vibrio fischeri, V. harveyi, and Photobacterium ...

journal_title：Journal of bioenergetics and biomembranes

authors： Bourgois JJ,Sluse FE,Baguet F,Mallefet J

更新日期：2001-08-01 00:00:00

abstract：:Mitochondrial reactive oxygen species (ROS) production was investigated in mitochondria extracted from liver of rats treated with or without metformin, a mild inhibitor of respiratory chain complex 1 used in type 2 diabetes. A high rate of ROS production, fully suppressed by rotenone, was evidenced in non-phosphorylat...

journal_title：Journal of bioenergetics and biomembranes

authors： Batandier C,Guigas B,Detaille D,El-Mir MY,Fontaine E,Rigoulet M,Leverve XM

更新日期：2006-02-01 00:00:00

abstract：:Thylakoids are highly protein-enriched membranes that harbor a number of multicomponent photosynthetic complexes. Similarly to other biological membranes the protein constituents are heterogeneously distributed laterally in the plane of the membrane, however the specific segregation into stacked (grana patches) and un...

journal_title：Journal of bioenergetics and biomembranes

authors： Petrova N,Todinova S,Paunov M,Kovács L,Taneva S,Krumova S

更新日期：2018-12-01 00:00:00