The binding of ATP to the catalytic and the regulatory site of Ca2+, Mg2+-dependent ATPase of the sarcoplasmic reticulum.

abstract：:The Mg2+ dependent asymmetry of the F(1)-ATPase catalytic sites leads to the differences in affinity for nucleotides and is an essential component of the binding-change mechanism. Changes in metal ligands during the catalytic cycle responsible for this asymmetry were characterized by vanadyl (V(IV) + O)2+, a functiona...

journal_title：Journal of bioenergetics and biomembranes

authors： Frasch WD

更新日期：2000-10-01 00:00:00

abstract：:Succinate-driven reverse electron transport (RET) is one of the main sources of mitochondrial reactive oxygen species (mtROS) in ischemia-reperfusion injury. RET is dependent on mitochondrial membrane potential (Δψm) and transmembrane pH difference (ΔpH), components of the proton motive force (pmf); a decrease in Δψm ...

journal_title：Journal of bioenergetics and biomembranes

authors： Komlódi T,Geibl FF,Sassani M,Ambrus A,Tretter L

更新日期：2018-10-01 00:00:00

abstract：:ATP1-111, a suppressor of the slow-growth phenotype of yme1Delta lacking mitochondrial DNA is due to the substitution of phenylalanine for valine at position 111 of the alpha-subunit of mitochondrial ATP synthase (Atp1p in yeast). The suppressing activity of ATP1-111 requires intact beta (Atp2p) and gamma (Atp3p) subu...

journal_title：Journal of bioenergetics and biomembranes

authors： Francis BR,White KH,Thorsness PE

更新日期：2007-04-01 00:00:00

abstract：:We summarize our current view of the reaction mechanism in F(1)-ATPase as it has emerged from experiment, theory, and computational studies over the last several years. ATP catalysis in the catalytic binding pockets of F(1) takes place without the release of any significant free energy and is efficiently driven by the...

journal_title：Journal of bioenergetics and biomembranes

authors： Dittrich M,Schulten K

更新日期：2005-12-01 00:00:00

abstract：:A series of amphiphilic polymethlyenecarboxymaleimides has been synthesized for use as sulfhydryl reagents applicable to membrane proteins. Physical properties of the compounds which are relevant to their proposed mode of action have been determined. By comparing rates of reaction in aqueous and aprotic solvents, the ...

journal_title：Journal of bioenergetics and biomembranes

authors： Griffiths DG,Partis MD,Churchill P,Brenner SC,Fleischer S,Moore RJ,Beechey RB

更新日期：1990-10-01 00:00:00

abstract：:Precursor proteins destined for the mitochondrial matrix traverse inner and outer organelle membranes in an extended conformation. Translocation events are therefore integrally coupled to the processes of protein unfolding in the cytosol and protein refolding in the matrix. To successfully import proteins from the cyt...

journal_title：Journal of bioenergetics and biomembranes

authors： Martin J

更新日期：1997-02-01 00:00:00

abstract：:Conformational changes within the subunit b-dimer of the E. coli ATP synthase occur upon binding to the F(1) sector. ESR spectra of spin-labeled b at room temperature indicated a pivotal point in the b-structure at residue 62. Spectra of frozen b +/- F(1) and calculated interspin distances suggested that where contact...

journal_title：Journal of bioenergetics and biomembranes

authors： Zaida TM,Hornung T,Volkov OA,Hoffman AD,Pandey SJ,Wise JG,Vogel PD

更新日期：2008-12-01 00:00:00

abstract：:F1-ATPases transiently entrap inhibitory MgADP in a catalytic site during turnover when noncatalytic sites are not saturated with ATP. An initial burst of ATP hydrolysis rapidly decelerates to a slow intermediate rate that gradually accelerates to a final steady-state rate. Transition from the intermediate to the fina...

journal_title：Journal of bioenergetics and biomembranes

authors： Allison WS,Jault JM,Dou C,Grodsky NB

更新日期：1996-10-01 00:00:00

abstract：:Recent progress regarding the structure of the Ca(2+)-translocating ATPase of sarcoplasmic reticulum in several conformational states, and a substantial accumulation of biochemical information about this and other P-type ATPases, have put everything in place for the final convergence of biochemistry and structure that...

journal_title：Journal of bioenergetics and biomembranes

authors： Scarborough GA

更新日期：2003-06-01 00:00:00

abstract：:The state-3 rate of respiration of potato tuber mitochondria is inhibited by concentrations of KCl or NaCl above 125 mM, and by concentrations of sucrose, lactose, or maltose above 500 mM, but not at all by mannitol, glucose, glycine, or proline up to a concentration of 1500 mM in the medium. Mitochondria from caulifl...

journal_title：Journal of bioenergetics and biomembranes

authors： Campbell LC,Raison JK,Brady CJ

更新日期：1976-06-01 00:00:00

abstract：:Evidence suggests membrane bound F(1)F(0)-ATPase complexes form stable associations such that dimers can be retrieved from detergent lysates of mitochondria isolated from a range of sources including algae, higher plants, yeast and bovine heart, and plant chloroplasts. The physiological relevance of these interactions...

journal_title：Journal of bioenergetics and biomembranes

authors： Gavin PD,Prescott M,Devenish RJ

更新日期：2005-04-01 00:00:00

abstract：:The multi-subunit vacuolar-type H(+)-ATPase consists of a V(1) domain (A-H subunits) catalyzing ATP hydrolysis and a V(0) domain (a, c, c', c", d, e) responsible for H(+) translocation. The mammalian V(0) d subunit is one of the least-well characterized, and its function and position within the pump are still unclear....

journal_title：Journal of bioenergetics and biomembranes

authors： Smith AN,Francis RW,Sorrell SL,Karet FE

更新日期：2008-08-01 00:00:00

abstract：:In Propionigenium modestum, ATP is manufactured from ADP and phosphate by the enzyme ATP synthase using the free energy of an electrochemical gradient of Na+ ions. The P. modestum ATP synthase is a clear member of the family of F-type ATP synthases and the only major distinction is an extension of the coupling ion spe...

journal_title：Journal of bioenergetics and biomembranes

authors： Dimroth P,Matthey U,Kaim G

更新日期：2000-10-01 00:00:00

abstract：:At present there is a poor understanding of the events that lead up to neuronal apoptosis that occurs in neurodegenerative diseases and following acute ischemic episodes. Apoptosis is critical for the elimination of unwanted neurons within the developing nervous system. The Bcl-2 family of proteins contains pro- and a...

journal_title：Journal of bioenergetics and biomembranes

authors： Ward MW,Kögel D,Prehn JH

更新日期：2004-08-01 00:00:00

abstract：:The cytochrome b6/f complex of higher plant chloroplasts is uniformly distributed throughout both appressed and nonappressed thylakoids, in contrast to photosystem II and photosystem I, the other major membrane protein complexes involved in electron transport. We discuss how this distribution is likely to affect inter...

journal_title：Journal of bioenergetics and biomembranes

authors： Allred DR,Staehelin LA

更新日期：1986-10-01 00:00:00

abstract：:The fungal plasma membrane contains a proton-translocating ATPase that is closely related, both structurally and functionally, to the [Na+, K+]-, [H+, K+]-, and [Ca2+]-ATPases of animal cells, the plasma-membrane [H+]-ATPase of higher plants, and several bacterial cation-transporting ATPases. This review summarizes cu...

journal_title：Journal of bioenergetics and biomembranes

authors： Nakamoto RK,Slayman CW

更新日期：1989-10-01 00:00:00

abstract：:Mitochondrial impairment has been collecting more and more attention as a contributing factor to the etiology of Parkinson's disease. Above all, the NADH-quinone oxidoreductase, complex I, of the respiratory chain seems to be most culpable. Complex I dysfunction is translated to an increased production of reactive oxy...

journal_title：Journal of bioenergetics and biomembranes

authors： Marella M,Seo BB,Yagi T,Matsuno-Yagi A

更新日期：2009-12-01 00:00:00

abstract：:Research on VDAC has accelerated as evidence grows of its importance in mitochondrial function and in apoptosis. New investigators entering the field are often confounded by the VDAC literature and its many apparent conflicts and contradictions. This review is an effort to shed light on the situation and identify reli...

journal_title：Journal of bioenergetics and biomembranes

authors： Rostovtseva TK,Tan W,Colombini M

更新日期：2005-06-01 00:00:00

abstract：:Mitochondrial cytochrome c (horse), which is a very efficient electron donor to bacterial photosynthetic reaction centers in vitro, binds to the reaction center of Rhodospirillum rubrum with an approximate dissociation constant of 0.3-0.5 microM at pH 8.2 and low ionic strength. The binding site for the reaction cente...

journal_title：Journal of bioenergetics and biomembranes

authors： Bosshard HR,Snozzi M,Bachofen R

更新日期：1987-08-01 00:00:00

abstract：:Overexpression of the Homo sapiens LYR motif containing 1 (LYRM1) causes mitochondrial dysfunction and induces insulin resistance in 3T3-L1 adipocytes. α-Lipoic acid (α-LA), a dithiol compound with antioxidant properties, improves glucose transport and utilization in 3T3-L1 adipocytes. The aim of this study was to inv...

journal_title：Journal of bioenergetics and biomembranes

authors： Qin ZY,Zhang M,Guo XR,Wang YM,Zhu GZ,Ni YH,Zhao YP,Qiu J,Kou CZ,Qin R,Cao XG

更新日期：2012-10-01 00:00:00

abstract：:Patch-clamp studies of the yeast Schizosaccharomyces pombe reveal that the plasma membrane contains a voltage-gated channel mildly selective for potassium over sodium, lithium, and chloride. The channel exhibits several conductances with a maximum of 153 pS. The channel gates in the region of physiologically relevant ...

journal_title：Journal of bioenergetics and biomembranes

authors： Vacata V,Höfer M,Larsson HP,Lecar H

更新日期：1993-02-01 00:00:00

abstract：:Free radical production and leak of brain nonsynaptic mitochondria were higher with pyruvate/malate than with succinate in rats and pigeons. Rotenone, antimycin A, and myxothiazol maximally stimulated free radical production with pyruvate/malate but not with succinate. Simultaneous treatment with myxothiazol plus anti...

journal_title：Journal of bioenergetics and biomembranes

authors： Barja G,Herrero A

更新日期：1998-06-01 00:00:00

abstract：:Eukaryotic porins or VDACs are a class of transmembrane proteins mainly localized in the outer mitochondrial membrane, whose function is to allow the diffusion of metabolites between the cytosol and the mitochondrion. In Drosophila melanogaster, as in other organisms, a small family of genes encoding porins has been d...

journal_title：Journal of bioenergetics and biomembranes

authors： Specchia V,Guarino F,Messina A,Bozzetti MP,De Pinto V

更新日期：2008-06-01 00:00:00

abstract：:Recent studies of isolated muscle membrane have enabled induction and monitoring of rapid Ca2+ release from sarcoplasmic reticulum (SR)5 in vitro by a variety of methods. On the other hand, various proteins that may be directly or indirectly involved in the Ca2+ release mechanism have begun to be unveiled. In this min...

journal_title：Journal of bioenergetics and biomembranes

authors： Ikemoto N,Ronjat M,Mészáros LG

更新日期：1989-04-01 00:00:00

abstract：:Heat shock protein 90 (Hsp90) is an attractive therapeutic target. Geldanamycin (GA), the first identified Hsp90 inhibitor, exhibited potent antitumor activity, but possessed significant hepatotoxicity. To overcome the hepatotoxicity derived from the quinone structure of GA, a non-quinone GA derivative 17-demethoxy-re...

journal_title：Journal of bioenergetics and biomembranes

authors： Zhao S,Li H,Jiang C,Ma T,Wu C,Huo Q,Liu H

更新日期：2015-10-01 00:00:00

abstract：:Mitochondria are dynamic structures for which fusion and fission are well characterized for rapidly dividing cells in culture. Based on these data, it has recently been proposed that high respiratory activity is the result of fusion and formation of mitochondrial reticulum, while fission results in fragmented mitochon...

journal_title：Journal of bioenergetics and biomembranes

authors： Varikmaa M,Guzun R,Grichine A,Gonzalez-Granillo M,Usson Y,Boucher F,Kaambre T,Saks V

更新日期：2013-08-01 00:00:00

abstract：:Hydroxyl radical (HO•) production in photosystem II (PSII) was studied by electron paramagnetic resonance (EPR) spin-trapping technique. It is demonstrated here that the exposure of PSII membranes to heat stress (40 °C) results in HO• formation, as monitored by the formation of EMPO-OH adduct EPR signal. The presence ...

journal_title：Journal of bioenergetics and biomembranes

authors： Yadav DK,Pospíšil P

更新日期：2012-06-01 00:00:00

abstract：:Electron transport from Photosystem II to Photosystem I of spinach chloroplasts can be stimulated by bicarbonate and various carbonyl or carboxyl compounds. Monovalent or divalent cations, which have hitherto been implicated in the energy distribution between the two photosystems, i.e., "spillover" phenomena at low li...

journal_title：Journal of bioenergetics and biomembranes

authors： Barr R,Melhem R,Lezotte AL,Crane FL

更新日期：1980-08-01 00:00:00

abstract：:The Nm23-H1/nucleoside diphosphate (NDP) kinase A is a metastasis suppressor, besides its enzymatic activity. The mutant S120G has been found in high-grade neuroblastomas. The mutant protein, once denatured in urea, is unable to refold in vitro. A size-exclusion chromatography analysis of the folding/association pathw...

journal_title：Journal of bioenergetics and biomembranes

authors： Lascu I

更新日期：2006-08-01 00:00:00

abstract：:The serotonergic system plays a crucial role in the energy balance regulation. Energy balance is mediated by food intake and caloric expenditure. Thus, the present study investigated the mechanisms that might be associated with fluoxetine treatment-induced weight reduction. Wistar male rat pups received daily injectio...

journal_title：Journal of bioenergetics and biomembranes

authors： da Silva AI,Braz GR,Pedroza AA,Nascimento L,Freitas CM,Ferreira DJ,Manhães de Castro R,Lagranha CJ

更新日期：2015-08-01 00:00:00