Insulin control of a transplasma membrane NADH dehydrogenase in erythrocyte membranes.

Abstract:

:A study of NADH ferricyanide reductase activity in oriented vesicles or open ghosts of human and porcine erythrocytes shows that the dehydrogenase activity can have three types of orientation in the membrane. There is activity which responds only to acceptors and NADH exclusively on the inside face, or exclusively on the outer surface. There is also activity which requires exposure of both sides of the membrane and thus is transmembranous. The transmembrane activity is inhibited by insulin, whereas the internal and external enzymes do not respond to insulin. The transmembrane dehydrogenase can be a basis for proton transport in the plasma membrane.

journal_name

J Bioenerg Biomembr

authors

Crane FL,Crane HE,Sun IL,MacKellar WC,Grebing C,Löw H

doi

10.1007/BF00743068

subject

Has Abstract

pub_date

1982-12-01 00:00:00

pages

425-33

issue

5-6

eissn

0145-479X

issn

1573-6881

journal_volume

14

pub_type

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