Experimental production of "septa" and apparent subdivision of muscle mitochondria.

abstract：:The respiratory chain of marine and moderately halophilic bacteria requires Na+ for maximum activity, and the site of Na(+)-dependent activation is located in the NADH-quinone reductase segment. The Na(+)-dependent NADH-quinone reductase purified from marine bacterium Vibrio alginolyticus is composed of three subunits...

journal_title：Journal of bioenergetics and biomembranes

authors： Unemoto T,Hayashi M

更新日期：1993-08-01 00:00:00

abstract：:Plasma membranes isolated from K562 cells contain an NADH-ascorbate free radical reductase activity and intact cells show the capacity to reduce the rate of chemical oxidation of ascorbate leading to its stabilization at the extracellular space. Both activities are stimulated by CoQ10 and inhibited by capsaicin and di...

journal_title：Journal of bioenergetics and biomembranes

authors： Gómez-Díaz C,Rodríguez-Aguilera JC,Barroso MP,Villalba JM,Navarro F,Crane FL,Navas P

更新日期：1997-06-01 00:00:00

abstract：:Evidence suggests membrane bound F(1)F(0)-ATPase complexes form stable associations such that dimers can be retrieved from detergent lysates of mitochondria isolated from a range of sources including algae, higher plants, yeast and bovine heart, and plant chloroplasts. The physiological relevance of these interactions...

journal_title：Journal of bioenergetics and biomembranes

authors： Gavin PD,Prescott M,Devenish RJ

更新日期：2005-04-01 00:00:00

abstract：:This introductory article and those that follow focus on the roles that mitochondria may have in cancer metastasis (spreading) that all too frequently leads to death of cancer patients. The history of cancer dates back in time to several thousand years BC and continues to this day. Although billions of dollars have be...

journal_title：Journal of bioenergetics and biomembranes

authors： Pedersen PL

更新日期：2012-12-01 00:00:00

abstract：:Hepatic iron toxicity because of iron overload seems to be mediated by lipid peroxidation of biological membranes and the associated organelle dysfunctions. However, the basic mechanisms underlying this process in vivo are still little understood. Gerbils were dosed with weekly injections of iron-dextran alone or in c...

journal_title：Journal of bioenergetics and biomembranes

authors： Masini A,Ceccarelli D,Giovannini F,Montosi G,Garuti C,Pietrangelo A

更新日期：2000-04-01 00:00:00

abstract：:For the past seven years or so, much discussion and controversy in the field of human evolution has revolved around the application and interpretation of studies of human mitochondrial DNA variation, particularly the hypothesis that all mtDNA types in contemporary populations can be traced back to a single African anc...

journal_title：Journal of bioenergetics and biomembranes

authors： Stoneking M

更新日期：1994-06-01 00:00:00

abstract：:The serotonergic system plays a crucial role in the energy balance regulation. Energy balance is mediated by food intake and caloric expenditure. Thus, the present study investigated the mechanisms that might be associated with fluoxetine treatment-induced weight reduction. Wistar male rat pups received daily injectio...

journal_title：Journal of bioenergetics and biomembranes

authors： da Silva AI,Braz GR,Pedroza AA,Nascimento L,Freitas CM,Ferreira DJ,Manhães de Castro R,Lagranha CJ

更新日期：2015-08-01 00:00:00

abstract：:Vicious cycle theories of aging and oxidative stress propose that ROS produced by the mitochondrial electron transport chain damage the mitochondria leading exponentially to more ROS production and mitochondrial damage. Although this theory is widely discussed in the field of research on aging and oxidative stress, th...

journal_title：Journal of bioenergetics and biomembranes

authors： Sanz A,Caro P,Gómez J,Barja G

更新日期：2006-04-01 00:00:00

abstract：:Many oxidoreductases are constructed from (a) local sites of strongly coupled substrate-redox cofactor partners participating in exchange of electron pairs, (b) electron pair/single electron transducing redox centers, and (c) nonadiabatic, long-distance, single-electron tunneling between weakly coupled redox centers. ...

journal_title：Journal of bioenergetics and biomembranes

authors： Moser CC,Page CC,Farid R,Dutton PL

更新日期：1995-06-01 00:00:00

abstract：:Gap junction channels have long been viewed as static structures containing a large-diameter, aqueous pore. This pore has a high permeability to hydrophilic molecules of approximately 900 daltons in molecular weight and a weak ionic selectivity. The evidence leading to these conclusions is reviewed in the context of m...

journal_title：Journal of bioenergetics and biomembranes

authors： Veenstra RD

更新日期：1996-08-01 00:00:00

abstract：:Available data indicate that minocycline, an antibiotic of the tetracycline family, has cytoprotective properties due to a direct interaction with mitochondria. Yet, the data in the case of isolated mitochondria suggest discrepant or even detrimental effect(s) of the interaction. We have studied the cytoprotective act...

journal_title：Journal of bioenergetics and biomembranes

authors： Karachitos A,Jordan J,Kmita H

更新日期：2012-06-01 00:00:00

abstract：:In this review, I focus on the bioenergetics of the methanogenic bacteria, with particular attention directed to the roles of transmembrane electrochemical gradients of sodium and proton. In addition, the mechanism of coupling ATP synthesis to methanogenic electron transfer is addressed. Evidence is reviewed which sug...

journal_title：Journal of bioenergetics and biomembranes

authors： Lancaster JR Jr

更新日期：1989-12-01 00:00:00

abstract：:F1-ATPases transiently entrap inhibitory MgADP in a catalytic site during turnover when noncatalytic sites are not saturated with ATP. An initial burst of ATP hydrolysis rapidly decelerates to a slow intermediate rate that gradually accelerates to a final steady-state rate. Transition from the intermediate to the fina...

journal_title：Journal of bioenergetics and biomembranes

authors： Allison WS,Jault JM,Dou C,Grodsky NB

更新日期：1996-10-01 00:00:00

abstract：:Reconstitution experiments were performed on lipid bilayer membranes in the presence of purified mitochondrial porin from yeast and of detergent-solubilized mitochondrial outer membranes of a porin-free yeast mutant. The addition of the porin resulted in a strong increase of the membrane conductance, which was caused ...

journal_title：Journal of bioenergetics and biomembranes

authors： Benz R,Schmid A,Dihanich M

更新日期：1989-08-01 00:00:00

abstract：:High-conductance calcium-activated potassium (maxi-K) channels comprise a specialized family of K+ channels. They are unique in their dual requirement for depolarization and Ca2+ binding for transition to the open, or conducting, state. Ion conduction through maxi-K channels is blocked by a family of venom-derived pep...

journal_title：Journal of bioenergetics and biomembranes

authors： Kaczorowski GJ,Knaus HG,Leonard RJ,McManus OB,Garcia ML

更新日期：1996-06-01 00:00:00

abstract：:The present state of the chemiosmotic concept is reviewed. Special attention is paid to (i) further progress in studies on the Na(+)-coupled energetics and (ii) paradoxical bioenergetic effects when protonic or sodium potentials are utilized outside the coupling membrane (TonB-mediated uphill transports across the out...

journal_title：Journal of bioenergetics and biomembranes

authors： Skulachev VP

更新日期：1994-12-01 00:00:00

abstract：:The topology of beef heart Complex III has been studied by tryptic and chymotryptic digestion of isolated Complex III, Mg2+-ATP submitochondrial particles, and mitoplasts. Degradation products were detected by the immunoreplication technique using specific antibodies against core protein 1 (50 K) and core protein 2 (4...

journal_title：Journal of bioenergetics and biomembranes

authors： Mendel-Hartvig I,Nelson BD

更新日期：1983-02-01 00:00:00

abstract：:Phosphatase activity of a kidney (Na + K)-ATPase preparation was optimally active with Mg2+ plus K+. Mn2+ was less effective and Ca2+ could not substitute for Mg2+. However, adding Ca2+ with Mg2+ or substituting Mn2+ for Mg2+ activated it appreciably in the absence of added K+, and all three divalent cations decreased...

journal_title：Journal of bioenergetics and biomembranes

authors： Robinson JD

更新日期：1985-06-01 00:00:00

abstract：:The plasma membrane-enriched fraction isolated from smooth muscle of rat gastric fundus was found to contain a substantial level of potassium-stimulated p-nitrophenylphosphatase activity (K-pNPPase), and its subcellular distribution closely resembled that of other plasma membrane enzyme markers. The kinetic profile of...

journal_title：Journal of bioenergetics and biomembranes

authors： Kostka P,Kwan CY

更新日期：1986-08-01 00:00:00

abstract：:N- and P/Q-type calcium channels are localized in high density in presynaptic nerve terminals and are crucial elements in neuronal excitation-secretion coupling. In addition to mediating Ca2+ entry to initiate transmitter release, they are thought to interact directly with proteins of the synaptic vesicle docking/fusi...

journal_title：Journal of bioenergetics and biomembranes

authors： Sheng ZH,Westenbroek RE,Catterall WA

更新日期：1998-08-01 00:00:00

abstract：:Signal peptidases, the endoproteases that remove the amino-terminal signal sequence from many secretory proteins, have been isolated from various sources. Seven signal peptidases have been purified, two from E. coli, two from mammalian sources, and three from mitochondrial matrix. The mitochondrial enzymes are soluble...

journal_title：Journal of bioenergetics and biomembranes

authors： Dev IK,Ray PH

更新日期：1990-06-01 00:00:00

abstract：:The cystic fibrosis transmembrane conductance regulator (CFTR) forms an anion-selective channel involved in epithelial chloride transport. Recent studies have provided new insights into the structural determinants of the channel's functional properties, such as anion selectivity, single-channel conductance, and gating...

journal_title：Journal of bioenergetics and biomembranes

authors： Akabas MH,Cheung M,Guinamard R

更新日期：1997-10-01 00:00:00

abstract：:Advanced glycation end products (AGEs) and methylglyoxal (MG), an important intermediate in AGEs synthesis, are thought to contribute to protein aging and to the pathogenesis of age-and diabetes-associated complications. This study was intended to investigate brain mitochondria bioenergetics and oxidative status of ra...

journal_title：Journal of bioenergetics and biomembranes

authors： Cardoso S,Carvalho C,Marinho R,Simões A,Sena CM,Matafome P,Santos MS,Seiça RM,Moreira PI

更新日期：2014-10-01 00:00:00

abstract：:Although the "Warburg effect", i.e., elevated glucose metabolism to lactic acid (glycolysis) even in the presence of oxygen, has been recognized as the most common biochemical phenotype of cancer for over 80 years, its biochemical and genetic basis remained unknown for over 50 years. Work focused on elucidating the un...

journal_title：Journal of bioenergetics and biomembranes

authors： Pedersen PL

更新日期：2012-02-01 00:00:00

abstract：:We have studied a mutant strain of Drosophila in which 80% of the mitochondrial DNA molecules have lost over 30% of their coding region through deletion. This deletion affects genes encoding five subunits of complex I of the respiratory chain (NADH:ubiquinone oxidoreductase). The enzymatic activity of complex I in the...

journal_title：Journal of bioenergetics and biomembranes

authors： Farge G,Touraille S,Lachaume P,Debise R,Procaccio V,Alziari S

更新日期：2004-04-01 00:00:00

abstract：:The 8-kDa subunit c of the E. coli F0 ATP-synthase proton channel was tested for Ca++ binding activity using a 45Ca++ ligand blot assay after transferring the protein from SDS-PAGE gels onto polyvinyl difluoride membranes. The purified subunit c binds 45Ca++ strongly with Ca++ binding properties very similar to those ...

journal_title：Journal of bioenergetics and biomembranes

authors： Zakharov SD,Li X,Red'ko TP,Dilley RA

更新日期：1996-12-01 00:00:00

abstract：:Many previous investigations have consistently reported that caloric restriction (40%), which increases maximum longevity, decreases mitochondrial reactive species (ROS) generation and oxidative damage to mitochondrial DNA (mtDNA) in laboratory rodents. These decreases take place in rat liver after only seven weeks of...

journal_title：Journal of bioenergetics and biomembranes

authors： Sanz A,Gómez J,Caro P,Barja G

更新日期：2006-12-01 00:00:00

abstract：:The inner membrane of yeast and mammalian mitochondria has been studied in situ with a patch clamp electrode. Anion channels were found in both cases, although their behavior and regulation are different. In mammalian mitochondria, the principal channel is of around 100 pS conductance and opens mainly under depolarize...

journal_title：Journal of bioenergetics and biomembranes

authors： Ballarin C,Sorgato MC

更新日期：1996-04-01 00:00:00

abstract：:Little is known on antimicrobial peptide permeation through outer membrane channels in gram-negative bacteria. Herein, we probed at a single-molecule level the interaction of two different peptides, magainin 2 and HPA3P with OmpF from E. coli. HPA3P is an analogue of the antimicrobial peptide HP(2-20) isolated from th...

journal_title：Journal of bioenergetics and biomembranes

authors： Apetrei A,Asandei A,Park Y,Hahm KS,Winterhalter M,Luchian T

更新日期：2010-04-01 00:00:00

abstract：:The mitochondrial inner membrane anion channel (IMAC) is a channel, identified by flux studies in intact mitochondria, which has a broad anion selectivity and is maintained closed or inactive by matrix Mg2+ and H+. We now present evidence that this channel, like many other chloride/anion channels, is reversibly blocke...

journal_title：Journal of bioenergetics and biomembranes

authors： Beavis AD,Davatol-Hag H

更新日期：1996-04-01 00:00:00