Molecular defects of NADH-ubiquinone oxidoreductase (complex I) in mitochondrial diseases.

abstract：:A sodium-dependent phosphate transporter (type II Na/Pi-cotransporter) was isolated which is expressed in apical membranes of proximal tubules and exhibits transport characteristics similar as described for renal reabsorption of phosphate. Type II associated Na/Pi-cotransport is electrogenic and results obtained by el...

journal_title：Journal of bioenergetics and biomembranes

authors： Biber J,Murer H,Forster I

更新日期：1998-04-01 00:00:00

abstract：:The present state of the chemiosmotic concept is reviewed. Special attention is paid to (i) further progress in studies on the Na(+)-coupled energetics and (ii) paradoxical bioenergetic effects when protonic or sodium potentials are utilized outside the coupling membrane (TonB-mediated uphill transports across the out...

journal_title：Journal of bioenergetics and biomembranes

authors： Skulachev VP

更新日期：1994-12-01 00:00:00

abstract：:Mitochondrial impairment has been collecting more and more attention as a contributing factor to the etiology of Parkinson's disease. Above all, the NADH-quinone oxidoreductase, complex I, of the respiratory chain seems to be most culpable. Complex I dysfunction is translated to an increased production of reactive oxy...

journal_title：Journal of bioenergetics and biomembranes

authors： Marella M,Seo BB,Yagi T,Matsuno-Yagi A

更新日期：2009-12-01 00:00:00

abstract：:Heat shock protein 90 (Hsp90) is an attractive therapeutic target. Geldanamycin (GA), the first identified Hsp90 inhibitor, exhibited potent antitumor activity, but possessed significant hepatotoxicity. To overcome the hepatotoxicity derived from the quinone structure of GA, a non-quinone GA derivative 17-demethoxy-re...

journal_title：Journal of bioenergetics and biomembranes

authors： Zhao S,Li H,Jiang C,Ma T,Wu C,Huo Q,Liu H

更新日期：2015-10-01 00:00:00

abstract：:Bacterial growth at the extremes of temperature has remained a fascinating aspect in the study of membrane function and structure. The stability of the integral membrane proteins of thermophiles make them particularly amenable to study. Respiratory enzymes of thermophiles appear to be functionally similar to the mesop...

journal_title：Journal of bioenergetics and biomembranes

authors： Konings WN,Tolner B,Speelmans G,Elferink MG,de Wit JG,Driessen AJ

更新日期：1992-12-01 00:00:00

abstract：:This study was designed to investigate the energetics of isolated rat hepatocyte swelling due to sodium-cotransported amino acid accumulation in a medium containing either glucose or octanoate as basal substrate. We show that the size of the increase in cytosolic volume is directly correlated with the total amino acid...

journal_title：Journal of bioenergetics and biomembranes

authors： Espié P,Devin A,Guérin B,Rigoulet M

更新日期：1997-12-01 00:00:00

abstract：:Recent progress is summarized on the structure, function, and regulation of the tricarboxylate (i.e., citrate) transport protein (CTP) from the rat liver mitochondrial inner membrane. The transporter has been purified and its reconstituted function characterized. A cDNA clone encoding the CTP has been isolated and seq...

journal_title：Journal of bioenergetics and biomembranes

authors： Kaplan RS,Mayor JA

更新日期：1993-10-01 00:00:00

abstract：:The midgut plasma membrane V-ATPase from larval Manduca sexta, the tobacco hornworm, is the sole energizer of any epithelial ion transport in this tissue and is responsible for the alkalinization of the gut lumen up to a pH of more than 11. This mini-review deals with those topics of research on this enzyme which may ...

journal_title：Journal of bioenergetics and biomembranes

authors： Wieczorek H,Grüber G,Harvey WR,Huss M,Merzendorfer H

更新日期：1999-02-01 00:00:00

abstract：:F1-ATPases transiently entrap inhibitory MgADP in a catalytic site during turnover when noncatalytic sites are not saturated with ATP. An initial burst of ATP hydrolysis rapidly decelerates to a slow intermediate rate that gradually accelerates to a final steady-state rate. Transition from the intermediate to the fina...

journal_title：Journal of bioenergetics and biomembranes

authors： Allison WS,Jault JM,Dou C,Grodsky NB

更新日期：1996-10-01 00:00:00

abstract：:Mitochondrial porin facilitates the diffusion of small hydrophilic molecules across the mitochondrial outer membrane. Despite low sequence similarity among porins from different species, a "glycine-leucine-lysine" (GLK) motif is conserved in mitochondrial and Neisseria porins. To investigate the possible roles of thes...

journal_title：Journal of bioenergetics and biomembranes

authors： Runke G,Maier E,O'Neil JD,Benz R,Court DA

更新日期：2000-12-01 00:00:00

abstract：:We summarize our current view of the reaction mechanism in F(1)-ATPase as it has emerged from experiment, theory, and computational studies over the last several years. ATP catalysis in the catalytic binding pockets of F(1) takes place without the release of any significant free energy and is efficiently driven by the...

journal_title：Journal of bioenergetics and biomembranes

authors： Dittrich M,Schulten K

更新日期：2005-12-01 00:00:00

abstract：:Oxygen plays a key role in bacterial bioluminescence. The simultaneous and continuous kinetics of oxygen consumption and light emission during a complete exhaustion of the exogenous oxygen present in a closed system has been investigated. The kinetics are performed with Vibrio fischeri, V. harveyi, and Photobacterium ...

journal_title：Journal of bioenergetics and biomembranes

authors： Bourgois JJ,Sluse FE,Baguet F,Mallefet J

更新日期：2001-08-01 00:00:00

abstract：:Recent advances in structural biology underlying mechanisms of channel gating have strengthened our knowledge about how K(+) channels can be inter-convertible between conductive and non-conductive states. We have reviewed and combined mutagenesis with biochemical, biophysical and structural information in order to und...

journal_title：Journal of bioenergetics and biomembranes

authors： Raja M,Olrichs NK,Vales E,Schrempf H

更新日期：2012-02-01 00:00:00

abstract：:A series of amphiphilic polymethlyenecarboxymaleimides has been synthesized for use as sulfhydryl reagents applicable to membrane proteins. Physical properties of the compounds which are relevant to their proposed mode of action have been determined. By comparing rates of reaction in aqueous and aprotic solvents, the ...

journal_title：Journal of bioenergetics and biomembranes

authors： Griffiths DG,Partis MD,Churchill P,Brenner SC,Fleischer S,Moore RJ,Beechey RB

更新日期：1990-10-01 00:00:00

abstract：:Hydroxyl radical (HO•) production in photosystem II (PSII) was studied by electron paramagnetic resonance (EPR) spin-trapping technique. It is demonstrated here that the exposure of PSII membranes to heat stress (40 °C) results in HO• formation, as monitored by the formation of EMPO-OH adduct EPR signal. The presence ...

journal_title：Journal of bioenergetics and biomembranes

authors： Yadav DK,Pospíšil P

更新日期：2012-06-01 00:00:00

abstract：:It is proven that any model of localized protonmotive energy coupling that relies upon properties of a homogeneous surface phase must, when operated in the steady state, lead to bulk phase electrochemical potentials for protons that are as large as those required by the delocalized chemiosmotic theory. To obtain model...

journal_title：Journal of bioenergetics and biomembranes

authors： Nagle JF,Dilley RA

更新日期：1986-02-01 00:00:00

abstract：:Two kinds of ATP binding sites were found on the ATPase molecule in deoxycholic acid-treated sarcoplasmic reticulum. One was the catalytic site (1 mol/mol active site) and its affinity was high. Upon addition of Ca2+, all the ATP bound to the catalytic site disappeared at 75 mM KCl, while a significant amount of ATP r...

journal_title：Journal of bioenergetics and biomembranes

authors： Nakamura Y,Tonomura Y

更新日期：1982-12-01 00:00:00

abstract：:The Nm23-H1/nucleoside diphosphate (NDP) kinase A is a metastasis suppressor, besides its enzymatic activity. The mutant S120G has been found in high-grade neuroblastomas. The mutant protein, once denatured in urea, is unable to refold in vitro. A size-exclusion chromatography analysis of the folding/association pathw...

journal_title：Journal of bioenergetics and biomembranes

authors： Lascu I

更新日期：2006-08-01 00:00:00

abstract：:Free radical production and leak of brain nonsynaptic mitochondria were higher with pyruvate/malate than with succinate in rats and pigeons. Rotenone, antimycin A, and myxothiazol maximally stimulated free radical production with pyruvate/malate but not with succinate. Simultaneous treatment with myxothiazol plus anti...

journal_title：Journal of bioenergetics and biomembranes

authors： Barja G,Herrero A

更新日期：1998-06-01 00:00:00

abstract：:We studied the importance of respiratory fitness in S. cerevisiae lifespan, response to caloric restriction (CR) and mtDNA stability. Mutants harboring mtDNA instability and electron transport defects do not respond to CR, while tricarboxylic acid cycle mutants presented extended lifespans due to CR. Interestingly, mt...

journal_title：Journal of bioenergetics and biomembranes

authors： Tahara EB,Cezário K,Souza-Pinto NC,Barros MH,Kowaltowski AJ

更新日期：2011-10-01 00:00:00

abstract：:2-Arachidonoylglicerol (2-AG) is an endocannabinoid that mimics the pharmacological effects of Δ⁹ tetrahydrocannabinol, the psychoactive component of the plant Cannabis sativa. It is present in many mammalian tissues, such as brain, liver, spleen, heart and kidney, where it exerts different biological effects either r...

journal_title：Journal of bioenergetics and biomembranes

authors： Zaccagnino P,D'Oria S,Romano LL,Di Venere A,Sardanelli AM,Lorusso M

更新日期：2012-04-01 00:00:00

abstract：:The development of new anti-neoplastic drugs is a key issue for cancer chemotherapy due to the reality that, most likely, certain cancer cells are resistant to current chemotherapy. The past two decades have witnessed tremendous advances in our understanding of the pathogenesis of cancer. These advances have allowed i...

journal_title：Journal of bioenergetics and biomembranes

authors： de Pedro N,Cautain B,Melguizo A,Vicente F,Genilloud O,Peláez F,Tormo JR

更新日期：2013-02-01 00:00:00

abstract：:Reaction of a dog kidney (Na + K)-ATPase with pyridoxal phosphate, followed by borohydride reduction, reduced the catalytic activity when measured subsequently. The time course of inactivation did not follow a first-order process, and certain characteristics of the residual enzymatic activity were modified. Moreover, ...

journal_title：Journal of bioenergetics and biomembranes

authors： Robinson JD

更新日期：1984-06-01 00:00:00

abstract：:Evidence suggests membrane bound F(1)F(0)-ATPase complexes form stable associations such that dimers can be retrieved from detergent lysates of mitochondria isolated from a range of sources including algae, higher plants, yeast and bovine heart, and plant chloroplasts. The physiological relevance of these interactions...

journal_title：Journal of bioenergetics and biomembranes

authors： Gavin PD,Prescott M,Devenish RJ

更新日期：2005-04-01 00:00:00

abstract：:Forkhead box protein O6 (FOXO6) has been recently identified as a novel regulator of oxidative stress in multiple pathological processes. However, whether FOXO6 participates in the regulation of oxidative stress of myocardial infarction is unclear. The present study was performed to evaluate the potential role of FOXO...

journal_title：Journal of bioenergetics and biomembranes

authors： Jin A,Zhang Q,Li S,Li B

更新日期：2020-12-01 00:00:00

abstract：:Hyperlipidemia is an important factor in the induction of cardiovascular diseases. However, the molecular mechanisms underlying the vascular injury involved in hyperlipidemia remains unclear. This study aimed to investigate the Notch pathway of endothelial progenitor cells (EPCs) in reendothelialization after vascular...

journal_title：Journal of bioenergetics and biomembranes

authors： Liang J,Ke X,Yang R,Wang X,Du Z,Hu C

更新日期：2020-12-01 00:00:00

abstract：:The 95 kDa subunit a of eukaryotic V-ATPases consists of a C-terminal, ion-translocating part and an N-terminal cytosolic domain. The latter's N-terminal domain (~40 kDa) is described to bind in an acidification-dependent manner with cytohesin-2 (ARNO), giving the V-ATPase the putative function as pH-sensing receptor....

journal_title：Journal of bioenergetics and biomembranes

authors： Dip PV,Saw WG,Roessle M,Marshansky V,Grüber G

更新日期：2012-06-01 00:00:00

abstract：:Idebenone (IDE), a synthetic analog of coenzyme Q, strongly activates glycerol phosphate (GP) oxidation in brown adipose tissue mitochondria. GP oxidase, GP cytochrome c oxidoreductase and GP dehydrogenase activities were all significantly stimulated by 13 muM IDE. Substituted derivatives of IDE acetyl- and methoxyide...

journal_title：Journal of bioenergetics and biomembranes

authors： Rauchová H,Drahota Z,Bergamini C,Fato R,Lenaz G

更新日期：2008-04-01 00:00:00

abstract：:Recent progress regarding the structure of the Ca(2+)-translocating ATPase of sarcoplasmic reticulum in several conformational states, and a substantial accumulation of biochemical information about this and other P-type ATPases, have put everything in place for the final convergence of biochemistry and structure that...

journal_title：Journal of bioenergetics and biomembranes

authors： Scarborough GA

更新日期：2003-06-01 00:00:00

abstract：:The production of all blood cells from hematopoietic stem cells (HSC) is highly sensitive to reactive oxygen species (ROS). Cumulating evidence suggests that mitochondria are critical for HSC fate determination. FOXO are known regulators of anti-oxidant response and key to the maintenance of HSC. Recent works indicate...

journal_title：Journal of bioenergetics and biomembranes

authors： Liang R,Ghaffari S

更新日期：2017-08-01 00:00:00