Abstract:
:We investigated the effects of K(ATP) channel openers diazoxide and pinacidil on the respiration rate and membrane potential (deltapsi) of rat heart mitochondria, oxidizing pyruvate and malate. Diazoxide and pinacidil (58.8-1348.3 microM) increased the V2 (-ADP) respiration rate accordingly by 13-208% and 30-273% and decreased the deltapsi by 2-17% and 6-55%. These effects were also similar in the respiration medium without K+. Moreover, carboxyatractyloside completely abolished diazoxide- and pinacidil-induced uncoupling, indicating a role for the mitochondrial adenine nucleotide translocase in this process.
journal_name
J Bioenerg Biomembrjournal_title
Journal of bioenergetics and biomembranesauthors
Kopustinskiene DM,Jovaisiene J,Liobikas J,Toleikis Adoi
10.1023/a:1013870704002keywords:
subject
Has Abstractpub_date
2002-02-01 00:00:00pages
49-53issue
1eissn
0145-479Xissn
1573-6881journal_volume
34pub_type
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