The Hfq homolog in Legionella pneumophila demonstrates regulation by LetA and RpoS and interacts with the global regulator CsrA.

Abstract:

:A gene in Legionella pneumophila that has significant homology to published hfq genes demonstrated regulation by RpoS and the transcriptional regulator LetA. Additionally, Hfq has a positive effect on the presence of transcripts of the genes for CsrA and the ferric uptake regulator Fur. Mutants lacking hfq demonstrate defects in growth and pigmentation and slight defects in virulence in both amoeba and macrophage infection models. Hfq appears to play a major role in exponential-phase regulatory cascades of L. pneumophila.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

McNealy TL,Forsbach-Birk V,Shi C,Marre R

doi

10.1128/JB.187.4.1527-1532.2005

keywords:

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

1527-32

issue

4

eissn

0021-9193

issn

1098-5530

pii

187/4/1527

journal_volume

187

pub_type

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