A homolog of the CtrA cell cycle regulator is present and essential in Sinorhizobium meliloti.

Abstract:

:During development of the symbiotic soil bacterium Sinorhizobium meliloti into nitrogen-fixing bacteroids, DNA replication and cell division cease and the cells undergo profound metabolic and morphological changes. Regulatory genes controlling the early stages of this process have not been identified. As a first step in the search for regulators of these events, we report the isolation and characterization of a ctrA gene from S. meliloti. We show that the S. meliloti CtrA belongs to the CtrA-like family of response regulators found in several alpha-proteobacteria. In Caulobacter crescentus, CtrA is essential and is a global regulator of multiple cell cycle functions. ctrA is also an essential gene in S. meliloti, and it is expressed similarly to the autoregulated C. crescentus ctrA in that both genes have complex promoter regions which bind phosphorylated CtrA.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Barnett MJ,Hung DY,Reisenauer A,Shapiro L,Long SR

doi

10.1128/JB.183.10.3204-3210.2001

keywords:

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

3204-10

issue

10

eissn

0021-9193

issn

1098-5530

journal_volume

183

pub_type

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