An lrp-like gene of Bacillus subtilis involved in branched-chain amino acid transport.

Abstract:

:The azlB locus of Bacillus subtilis was defined previously by a mutation conferring resistance to a leucine analog, 4-azaleucine (J. B. Ward, Jr., and S. A. Zahler, J. Bacteriol. 116:727-735, 1973). In this report, azlB is shown to be the first gene of an operon apparently involved in branched-chain amino acid transport. The product of the azlB gene is an Lrp-like protein that negatively regulates expression of the azlBCDEF operon. Resistance to 4-azaleucine in azlB mutants is due to overproduction of AzlC and AzlD, two novel hydrophobic proteins.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Belitsky BR,Gustafsson MC,Sonenshein AL,Von Wachenfeldt C

doi

10.1128/jb.179.17.5448-5457.1997

subject

Has Abstract

pub_date

1997-09-01 00:00:00

pages

5448-57

issue

17

eissn

0021-9193

issn

1098-5530

journal_volume

179

pub_type

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