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Identification of phosphoprotein:phosphoprotein and phosphoprotein:nucleocapsid protein interaction domains of the Newcastle disease virus.

Abstract：

:The yeast two-hybrid system has been used to identify domains of the Newcastle disease virus (NDV) phosphoprotein (P) involved in self-association and interaction with the nucleocapsid protein (NP). Deletion analysis was used to map the domain(s) of the P protein involved in P:P and P:NP interactions. The C-terminal 45 amino acids (residues 247-291) were shown to play a major role in both of the interactions. Comparison of these findings with other reports suggests that paramyxoviruses are different with respect to interaction domain(s) between these two essential viral proteins involved in genome replication.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Jahanshiri F,Eshaghi M,Yusoff K

doi

10.1007/s00705-004-0439-z

keywords:

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

611-8

issue

3

eissn

0304-8608

issn

1432-8798

journal_volume

150

pub_type

杂志文章

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