Abstract：
:Murine monoclonal antibodies against the fusion (F) and hemagglutinin-neuraminidase (HN) proteins of Sendai virus (SV) were prepared and studied on their antiviral activities, particularly on the neutralization of infectivity. On the analysis with solid phase competitive ELISA, 26 anti-HN antibodies were divided into at least four groups (HN-I, -II, -III and -IV). Antigenic sites recognized by the HN-I, -II, and -III group antibodies topographically separate from each other. Sites recognized by the HN-IV group antibodies overlaps partially with ones recognized by the HN-I, HN-II and -III group antibodies. The antibodies belonging to the HN-III group highly neutralize the infectivity of SV and weakly or not at all inhibit the hemagglutination (HA). In contrast, the HN-IV group antibodies strongly inhibit HA, but weakly neutralize the infectivity. Adsorption of SV to chicken red blood cells or L cells is inhibited by the HN-IV antibodies, but scarcely by the HN-III antibodies. On the other hand, incubation with HN-III antibodies of HeLa cells that have been preadsorbed with SV at 4 degrees C, followed by culture at 37 degrees C, causes inhibition of infection, but the HN-IV antibodies do not effectively interfere with such infection. The competitive ELISA showed that 17 anti-F antibodies were divided into two groups (F-I and -II). Two antigenic sites recognized by the antibodies, however, seem to be near to each other because a certain competition is observed between the antibodies of both groups. Two of the seven antibodies belonging to the F-II group inhibit the hemolysis activity and also neutralize the infectivity of SV, but the other five F-II antibodies do not. One of the anti-F antibodies has a low HI activity, and, in competition tests, competes with one of the anti-HN antibodies (HN-IV).
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Tozawa H,Komatsu H,Ohkata K,Nakajima T,Watanabe M,Tanaka Y,Arifuku Mdoi
10.1007/BF01316735subject
Has Abstractpub_date
1986-01-01 00:00:00pages
145-61issue
1-2eissn
0304-8608issn
1432-8798journal_volume
91pub_type
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journal_title：Archives of virology
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更新日期：1994-01-01 00:00:00
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更新日期：1995-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：1995-01-01 00:00:00
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更新日期：1984-01-01 00:00:00
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更新日期：1982-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2001-12-01 00:00:00
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更新日期：1992-01-01 00:00:00
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更新日期：1984-01-01 00:00:00
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journal_title：Archives of virology
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更新日期：1980-01-01 00:00:00
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更新日期：2003-07-01 00:00:00
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journal_title：Archives of virology
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