Abstract：
:Swine influenza (SI) is an acute respiratory disease of pigs, caused by swine influenza virus (SIV). Little is known about the inflammatory response in the lung during acute SI and its correlation with clinical signs or lung pathology. Moreover, until now there has been a limited amount of data available on the relationship between the concentrations of pro- and anti-inflammatory cytokines in the lungs and the serum concentration of acute-phase proteins (APPs) in SIV-infected pigs. In the present study, the porcine inflammatory and immune responses during acute influenza caused by H1N1 SIV (SwH1N1) were studied. Nine pigs were infected intratracheally, and five served as controls. Antibodies against SIV were measured by haemagglutination inhibition assay, and the influenza-virus-specific T-cell response was measured using a proliferation assay. C-reactive protein (CRP), haptoglobin (Hp), serum amyloid A (SAA), and pig major acute-phase protein (Pig-MAP) the concentrations in serum and concentration of IL-1β, IL-6, IL-8, IL-10, TNF-α and IFN-γ in lung tissues were measured using commercial ELISAs.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Pomorska-Mól M,Markowska-Daniel I,Kwit K,Czyżewska E,Dors A,Rachubik J,Pejsak Zdoi
10.1007/s00705-014-2116-1subject
Has Abstractpub_date
2014-10-01 00:00:00pages
2605-14issue
10eissn
0304-8608issn
1432-8798journal_volume
159pub_type
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