Abstract:
:This study aimed at investigating the effect of progesterone on interferon signaling pathways in peripheral blood mononuclear cells (PBMCs) of patients infected with hepatitis C virus (HCV). PBMCs were isolated from peripheral blood of 38 treatment-naïve HCV-infected patients, pooled, and stimulated with progesterone in the presence and absence of its receptor antagonist, mifepristone, along with interferon alpha (IFN-α) or imiquimod. Toll-like receptor (TLR) 7 and myxovirus resistance protein A (MxA) were quantified in PBMCs using RT-qPCR. Imiquimod alone or combined with progesterone did not change MxA expression in HCV-infected PBMCs. Progesterone decreased the inducing effect of IFN-α on TLR-7 expression in both males and females. Moreover, progesterone stimulation prior to IFN-α treatment attenuated the Jak/STAT pathway, which was reflected by decreased expression of MxA in females. Progesterone showed a negative impact on the IFN signaling pathway in HCV-infected PBMCs as it decreased the expression of TLR-7 in both genders, while MxA expression was decreased only in females.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Tayel SS,Helmy AA,Ahmed R,Esmat G,Hamdi N,Abdelaziz AIdoi
10.1007/s00705-013-1673-zsubject
Has Abstractpub_date
2013-08-01 00:00:00pages
1755-64issue
8eissn
0304-8608issn
1432-8798journal_volume
158pub_type
杂志文章abstract::In our attempt to isolate mutant cell lines resistant to Newcastle disease virus (NDV) we developed an improved procedure for enrichment of NDV-resistant cells from mouse FM3A cells and isolated a novel NDV-resistant mutant cell line, Had-2, with characteristics different from Had-1, a previously reported NDV-receptor...
journal_title:Archives of virology
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journal_title:Archives of virology
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journal_title:Archives of virology
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1007/s00705-005-0660-4
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1007/s007050050394
更新日期:1998-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00705-019-04205-0
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pub_type: 杂志文章
doi:10.1007/s00705-011-1166-x
更新日期:2012-02-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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