Piperacillin and ceftazidime produce the strongest synergistic phage-antibiotic effect in Pseudomonas aeruginosa.

Abstract:

:The combined use of phage and antibiotics can show synergistic antimicrobial effects, so-called phage-antibiotic synergy (PAS). Here, we screened and examined PAS against Pseudomonas aeruginosa in vitro. Testing four different phages infecting P. aeruginosa, phage KPP22 classified within the family Myoviridae genus Pbunavirus showed PAS with the widest range of antibiotics, and showed PAS with anti-Pseudomonas drugs such as piperacillin and ceftazidime. Thus, evidence suggests that the combined use of phage and antibiotics is a promising therapeutic strategy against P. aeruginosa infections, with consideration needed regarding the optimal selection and adequate application timing of these phages and antibiotics.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Uchiyama J,Shigehisa R,Nasukawa T,Mizukami K,Takemura-Uchiyama I,Ujihara T,Murakami H,Imanishi I,Nishifuji K,Sakaguchi M,Matsuzaki S

doi

10.1007/s00705-018-3811-0

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

1941-1948

issue

7

eissn

0304-8608

issn

1432-8798

pii

10.1007/s00705-018-3811-0

journal_volume

163

pub_type

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