Abstract：
:The objective of this study was to test the ability of bovine viral diarrhea virus (BVDV) to infect mice. Two mice each were either mock infected or inoculated with one of three BVDV strains by the intraperitoneal (IP) (n = 8) or intranasal (IN) (n = 8) route. All mice were euthanized at day 7 postinfection (p.i.). None of the infected mice exhibited any clinical signs of illness; however, the tissues harvested after BVDV challenge showed significant histopathological changes. Blood samples from five mice that were injected IP and one mouse that was inoculated IN were positive for BVDV by reverse transcription polymerase chain reaction (RT-PCR). Immunohistochemistry (IHC) was used to assess the presence of viral antigen in the organs of mice infected with three BVDV strains. In IP-injected mice, BVDV antigen was detected in the spleen (5/6), mesenteric lymph nodes (4/6), lymphatic tissue of the lung (3/6), lung (1/6), and stomach (1/6) of the infected mice; however, it was not detected in the liver (0/6) or kidney (0/6). In IN-inoculated mice, BVDV antigen was detected in the lung and mesenteric lymph nodes of one BVDV-infected mouse but was not detected in other tissues. The results of this study suggest that the spleen is the most reliable tissue for BVDV antigen detection using IHC in the IP-injected group. Our study demonstrates that mice can be infected by BVDV. This is the first report of BVDV infection in mice.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Seong G,Oem JK,Lee KH,Choi KSdoi
10.1007/s00705-015-2412-4subject
Has Abstractpub_date
2015-06-01 00:00:00pages
1565-71issue
6eissn
0304-8608issn
1432-8798journal_volume
160pub_type
杂志文章abstract：:Purified DNA from 45 isolates of suis herpes virus 1 (SHV1) collected between 1980 and 1987 from clinical outbreaks of Aujeszky's disease on French farms was compared by restriction fragment pattern (RFP) analysis. The BamHI generated RFPs were found to be distinguishable, confirming RFP analysis as a potential epidem...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01323161
更新日期：1990-01-01 00:00:00
abstract：:Human cytomegalovirus (HCMV) has evolved several immune-evasion strategies. One strategy involves encoding Fcgamma receptor (FcγR)-like proteins that thwart the Fcγ-mediated effector functions. Our aim was to determine whether GM allotypes-immunoglobulin γ chain determinants expressed primarily on the Fc segment-modul...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-011-0937-8
更新日期：2011-05-01 00:00:00
abstract：:Trigeminal ganglia from swine latently infected with pseudorabies virus (PRV) were examined for the presence of PRV nucleic acids by in situ hybridization. Both viral DNA and RNA were detectable in latently infected neurons, indicating that the PRV genome is transcriptionally active during the latent phase of infectio...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01321010
更新日期：1988-01-01 00:00:00
abstract：:Degenerate primers were used to detect and amplify 3'-terminal genome fragments of potyviruses from medicinal aroid plants growing at 16 sites in China. Virus was detected in 7 samples of which six, all of Pinellia ternata, contained a strain of soybean mosaic virus (SMV) similar to that previously reported from this ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-004-0390-z
更新日期：2005-01-01 00:00:00
abstract：:The IL28B gene is associated with spontaneous or treatment-induced HCV viral clearance. However, the mechanism by which the IL28B single nucleotide polymorphism (SNP) affects the extra-hepatic HCV immune responses and its relationship to HCV pathogenesis have not been thoroughly investigated. To examine the mechanism ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-016-3015-4
更新日期：2016-11-01 00:00:00
abstract：:Yellow fever was presumably imported to the Americas from West-Africa from the 16th to the 19th century. American and African genotypes of the virus are distinguishable, indicating separate evolution in different vector/host cycles. The complete nucleotide sequence of the yellow fever virus strain TRINID79A, isolated ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050050708
更新日期：1999-01-01 00:00:00
abstract：:The gene encoding protein p10, a structural protein of African swine fever (ASF) virus, has been mapped, sequenced and expressed in E. coli. Protein p10 was purified from dissociated virus by reverse-phase HPLC, and its NH2-terminal end identified by automated Edman degradation. To map the gene encoding protein p10, a...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01318999
更新日期：1993-01-01 00:00:00
abstract：:In our attempt to isolate mutant cell lines resistant to Newcastle disease virus (NDV) we developed an improved procedure for enrichment of NDV-resistant cells from mouse FM3A cells and isolated a novel NDV-resistant mutant cell line, Had-2, with characteristics different from Had-1, a previously reported NDV-receptor...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01310796
更新日期：1994-01-01 00:00:00
abstract：:Human metapneumovirus (hMPV) causes both upper and lower respiratory tract infection worldwide. Because little is known about the estimated level of exposure to hMPV in Taiwan, data for 1999 are presented. One thousand one hundred twenty sera from otherwise healthy community-based subjects aged 1 month to 99 years wer...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-010-0596-1
更新日期：2010-03-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-012-1370-3
更新日期：2012-10-01 00:00:00
abstract：:In a virus-infected plant, small interfering RNAs (siRNAs) corresponding to the viral genome form a large proportion of the small RNA population. It is possible to reassemble significant portions of the virus sequence from overlapping siRNA sequences and use these to identify the virus. We tested this technique with a...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-011-0979-y
更新日期：2011-07-01 00:00:00
abstract：:The complete nucleotide sequence (4838 nucleotides) of Iris yellow spot virus (IYSV) M RNA indicates, typical for tospoviruses, the presence of two genes in ambisense arrangement. The vRNA ORF codes for the potential cell-to-cell movement (NSm) protein (34.8 kDa) and the vcRNA ORF for the viral glycoprotein (G1/G2) pr...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-002-0885-4
更新日期：2002-12-01 00:00:00
abstract：:Strawberry crinkle disease is one of the major diseases that threatens strawberry production. Although the biological properties of the agent, strawberry crinkle virus (SCV), have been thoroughly investigated, its complete genome sequence has never been published. Existing RT-PCR-based detection relies on a partial se...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-018-3860-4
更新日期：2018-09-01 00:00:00
abstract：:Recombinants with known gene constellations between fowl plague virus (FPV) and various prototype influenza virus strains have been examined for neurovirulence in suckling mice. Strongly neurotropic recombinants were obtained from crosses between FPV and the strains virus N, Hong Kong, and PR8, but not between FPV and...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01314891
更新日期：1983-01-01 00:00:00
abstract：:The highly conserved encapsidation signal (epsilon) of hepatitis B viral (HBV) pregenomic RNA has been reported as an essential component for encapsidation and protein priming of HBV polymerase. Here, we report that two HBV epsilon RNA-binding host proteins (80 and 43 kDa) and a copurifying protein (100 kDa) were puri...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050200001
更新日期：2002-03-01 00:00:00
abstract：:Rabbit antisera to the stump-tailed macaque polyomavirus (STMV) which had been shown by immunoelectron microscopy and indirect immunofluorescence to react with the polyomavirus found in FRhK-4 cells (FRKV), also gave precipitin lines in counter-immunoelectrophoresis (CIE) and double diffusion in gel (GD) when reacted ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01311311
更新日期：1983-01-01 00:00:00
abstract：:In this study, bovine enteric caliciviruses (BECs) were detected in 49.4% of a total of 253 stool specimens for diarrheic calves collected from 42 industrial dairy farms from March 2010 to February 2012. Genogroup III norovirus (NoVsGIII) were more prevalent (39.5%) than neboviruses (NBs) (15%), and coinfections were ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-018-3716-y
更新日期：2018-05-01 00:00:00
abstract：:Four geographic variants (topotypes) of yellow fever (YF) virus from Africa and South America previously determined by RNA oligonucleotide mapping were analyzed for their structural, antigenic and virulence characteristics. The electrophoretic migration mobility and carbohydrate content of the envelope protein E chara...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01310727
更新日期：1987-01-01 00:00:00
abstract：:In the current study, the complete genome sequence of a member of the family Astroviridae isolated from pigeons was determined through genetic characterization and phylogeny analysis. The isolated genome sequence was proposed to be that of pigeon avian nephritis virus (ANV), whose genome structure and characteristics ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-011-1034-8
更新日期：2011-09-01 00:00:00
abstract：:Simultaneous infection of primary rabbit kidney cells with HSV type 1 TK+ and a TK- strain results in a mutual influence of both viruses on the induction of thymidine kinase (TK). TK+ virus has an enhancing and TK- virus a depressing effect on TK induction by a superinfecting TK+ virus. The enzyme induction depends on...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01317531
更新日期：1975-01-01 00:00:00
abstract：:The hemagglutinin-esterase (HE) protein of betacoronavirus lineage A is a secondary receptor in the infection process and is involved in the emergence of new betacoronavirus genotypes with altered host specificity and tissue tropism. We previously reported a novel recombinant bovine coronavirus (BCoV) strain that was ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-020-04840-y
更新日期：2020-12-01 00:00:00
abstract：:Here, we infected mice with cytopathic bovine viral diarrhea virus 1 (cp BVDV1) by oral inoculation and investigated the effects of infection by histopathological, immunohistochemical (IHC), hematological methods. Twelve mice were infected, and samples were obtained at day 2, 5, and 9 postinfection (pi). Most of the i...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-015-2649-y
更新日期：2016-02-01 00:00:00
abstract：:Human papillomaviruses (HPVs) are responsible for the most common human sexually transmitted viral infections. Infection with high-risk HPVs, particularly HPV16, is associated with the development of cervical cancer. The papillomavirus L1 major capsid protein, the basis of the currently marketed vaccines, self-assembl...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-009-0484-8
更新日期：2009-01-01 00:00:00
abstract：:A novel virus we call zucchini green mottle mosaic virus (ZGMMV) was isolated from zucchini squash and its properties were determined. The size and shape of its virions, and other properties suggest that the virus is a tobamovirus. The coat protein (CP) genes of ZGMMV and kyuri green mottle mosaic virus (KGMMV), which...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050070023
更新日期：2000-01-01 00:00:00
abstract：:Among the four flavonoids tested quercetin and morin proved to be significantly effective against lethal Mengo virus-induced encephalitis in mice when the drugs were adminsitered orally (p.o.). With subcutaneous (s.c.) administration all four drugs failed to prevent mortality in the infected mice. Quercetin produced m...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01315089
更新日期：1978-01-01 00:00:00
abstract：:H9N2 avian influenza virus has caused huge economic loss for the Chinese poultry industry since it was first identified. Vaccination is frequently used as a control method for the disease. Meanwhile suspension culture has become an important tool for the development of influenza vaccines. To optimize the suspension cu...
journal_title：Archives of virology
pub_type： 临床试验,杂志文章
doi：10.1007/s00705-017-3460-8
更新日期：2017-10-01 00:00:00
abstract：:The M protein, encoded by the porcine reproductive and respiratory syndrome virus (PRRSV) ORF6 gene, is considered to be one of the most conserved PRRSV proteins. In recent decades, highly specific monoclonal antibodies (Mabs) have been exploited to provide reliable diagnoses for many diseases. In this study, two diff...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-014-2174-4
更新日期：2014-11-01 00:00:00
abstract：:Molecular studies have been carried out on Tomato mild mottle virus (TMMV) and 2322 nucleotides of the aphid-transmitted virus have been sequenced. This translates to a 2187 nucleotide open reading frame and a 135 nucleotide untranslated region (UTR) followed by a poly A tail. The sequence is consistent with the NIb a...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050170013
更新日期：2001-12-01 00:00:00
abstract：:Two day-old athymic (rnu/rnu) and euthymic (rnu/+) rat pups nursing immune or non-immune dams were inoculated oronasally with the Yale strain of rat virus (RV-Y). All athymic and euthymic pups (57/57) from immune dams remained clinically normal, whereas 51 of 66 athymic and euthymic pups from non-immune dams died with...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01311299
更新日期：1991-01-01 00:00:00
abstract：:RNA2, the short segment of the genome of Dicenthrarchus labrax encephalitis virus (DIEV), a fish nodavirus causing seabass encephalitis, was cloned. Sequence analysis revealed that DIEV RNA2 contains a single open reading frame (ORF), which carries the catalytic D-75 residue but lacks the site for autocatalytic proteo...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050050248
更新日期：1997-01-01 00:00:00
