S-adenosylmethionine and Pneumocystis.

Abstract:

:Pneumocystis is a parasitic fungus causing pneumonia in immunosuppressed mammals and S-adenosylmethionine a key intermediary metabolite for all cells. Other than a species of Rickettsia bacteria and an aberrant strain of the protozoan Amoeba proteus, Pneumocystis is the only cell known unable to synthesize AdoMet; it must extract this key compound from its host. This was discovered using a culture system and confirmed by observing depletion of AdoMet in the plasma of infected animals. Depletion also occurs in patients with Pneumocystis pneumonia (PcP), a phenomenon suggested as a basis for a method for diagnosis and evaluation of response to therapy. Preliminary data indicate that deliberate reduction of host lung AdoMet by nicotine treatment is therapeutic in the rat model of Pneumocystis pneumonia.

journal_name

FEMS Microbiol Lett

authors

Merali S,Clarkson AB Jr

doi

10.1016/j.femsle.2004.06.039

keywords:

subject

Has Abstract

pub_date

2004-08-15 00:00:00

pages

179-86

issue

2

eissn

0378-1097

issn

1574-6968

pii

S0378-1097(04)00458-6

journal_volume

237

pub_type

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