Abstract:
:NadR is the repressor protein that controls the expression of genes for NAD synthesis. It is also believed to be involved in nucleotide transport. Point mutations conferring different phenotypes were localized to six different regions within the nadR gene. That mutations affecting repression and transport all mapped within nadR confirms the bifunctional model for NadR action. The clustering of these mutations and 2 fusions revealed that those affecting repression lie in the amino terminal while those affecting transport occur in the carboxy-terminal. Mutations resulting in superrepression occurred within a central region of NadR that probably senses NAD concentrations. This region is predicted to direct the transition between NadR transport and repressor conformations.
journal_name
FEMS Microbiol Lettjournal_title
FEMS microbiology lettersauthors
Foster JW,Penfound Tdoi
10.1111/j.1574-6968.1993.tb06445.xsubject
Has Abstractpub_date
1993-09-01 00:00:00pages
179-83issue
2eissn
0378-1097issn
1574-6968journal_volume
112pub_type
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