Abstract:
:During a Plasmodium chabaudi infection in interleukin-10 (IL-10) knockout mice, there is greater parasite sequestration, more severe cerebral edema, and a high frequency of cerebral hemorrhage compared with infection of C57BL/6 mice. Anti-tumor necrosis factor alpha treatment ameliorated both cerebral edema and hemorrhages, suggesting that proinflammatory responses contributed to cerebral complications in infected IL-10(-/-) mice.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Sanni LA,Jarra W,Li C,Langhorne Jdoi
10.1128/iai.72.5.3054-3058.2004keywords:
subject
Has Abstractpub_date
2004-05-01 00:00:00pages
3054-8issue
5eissn
0019-9567issn
1098-5522journal_volume
72pub_type
杂志文章abstract::Patent filarial infection is associated with the downregulation of parasite-specific immune reactivity. In the present study, the relationship between in vitro parasite antigen-specific humoral and cellular immune responsiveness was investigated in Brugia pahangi-infected jirds and in jirds immunized with soluble anti...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.56.12.3052-3057.1988
更新日期:1988-12-01 00:00:00
abstract::Using microarray technology, we studied the early differential expression of 3,528 genes in human meningothelial cells in response to meningococcal challenge. Thirty-two genes were up-regulated, and four were down-regulated. Those up-regulated included the tumor necrosis factor alpha, interleukin-6 (IL-6), and IL-8 (b...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.4.2718-2722.2001
更新日期:2001-04-01 00:00:00
abstract::Serotype b-specific polysaccharide antigen (SPA) was extracted from whole cells of Actinobacillus actinomycetemcomitans Y4 by autoclaving and purified by chromatography on DEAE-Sephadex A-25 and Sephacryl S-300. SPA induced the release of monocyte and leukocyte chemotactic factors by human monocytes. Polymyxin B had a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.7.2563-2570.1996
更新日期:1996-07-01 00:00:00
abstract::Tick saliva has potent immunomodulatory properties. In arthropod-borne diseases, this effect is largely used by microorganisms to increase their pathogenicity and to evade host immune responses. We show that in Lyme borreliosis, tick salivary gland extract and a tick saliva protein, Salp15, inhibit in vitro keratinocy...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00482-10
更新日期:2011-02-01 00:00:00
abstract::A synthetic peptide whose sequence was derived from the circumsporozoite protein of Plasmodium knowlesi coupled to bovine gamma globulin has been shown to be immunogenic when administered with Freund complete adjuvant. The present experiments were designed to test the immunogenicity of the peptide when attached to a t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.48.3.839-842.1985
更新日期:1985-06-01 00:00:00
abstract::H(2)O(2) levels accumulated by Mycoplasma pneumoniae can be influenced by carbon source, different horse sera, yeast extract, thallium acetate, or growth in a simplified, dialyzed medium. Thus, increased levels of H(2)O(2) were detected by growth in glycerol, by omission of thallium acetate, and by the use of dialyzed...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.3.1.80-86.1971
更新日期:1971-01-01 00:00:00
abstract::Results of earlier investigations have indicated that the saprobic phase of Coccidioides immitis produces a heat-stable, 19-kDa antigen with serine proteinase activity which has been suggested to be specific for this pathogenic fungus. In the present study we have determined the N-terminal and partial internal amino a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.10.3994-4002.1995
更新日期:1995-10-01 00:00:00
abstract::A murine immunoglobulin G monoclonal antibody (MAb) raised against outer membrane vesicles of Moraxella catarrhalis 035E was shown to bind to a surface-exposed epitope of a major outer membrane protein of this organism. This outer membrane protein, which had an apparent molecular weight of approximately 80,000 in sodi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.5.2003-2010.1993
更新日期:1993-05-01 00:00:00
abstract::A GroEL-like protein from Bordetella pertussis was purified. This protein was found to have the tetradecameric subunit structure typical of the GroEL family of proteins and to contain epitopes similar to those of other members of this family, including a human GroEL-like protein. Active immunization of neonatal mice w...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.4.1417-1422.1991
更新日期:1991-04-01 00:00:00
abstract::Alveolar bone destruction is a characteristic feature of periodontitis. Treponema denticola is known to be involved in periodontitis. To elucidate the role of T. denticola in alveolar bone destruction in periodontitis, the effects of lipooligosaccharide (LOS) from T. denticola on osteoclast formation and on expression...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.1.226-233.2003
更新日期:2003-01-01 00:00:00
abstract::This study focuses on the interaction of the three components of the Bacillus cereus Nhe enterotoxin with particular emphasis on the functional roles of NheB and NheC. The results demonstrated that both NheB and NheC were able to bind to Vero cells directly while NheA lacked this ability. It was also shown that Nhe-in...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00247-10
更新日期:2010-09-01 00:00:00
abstract::The role of the hypothalamus-pituitary-adrenal (HPA) axis in regulating the growth of Mycobacterium avium in Mycobacterium bovis BCG-resistant and -susceptible congenic mice was evaluated. Restraint was used to activate the HPA axis, which resulted in an increase in the level of corticosterone in the plasma. Activatio...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.11.4793-4800.1993
更新日期:1993-11-01 00:00:00
abstract::The ability of human clinical isolates of Yersinia enterocolitica to interact with HEp-2 cells was found to vary considerably between the serotypes O:3, O:8, and O:9. Although all three serotypes adhered initially to the cell surface, regardless of incubation temperature of the bacterial inoculum or presence of the 40...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.52.1.85-89.1986
更新日期:1986-04-01 00:00:00
abstract::Incubation of large granular lymphocytes (LGL) with glutaraldehyde-fixed bacteria stimulated in the supernatant the production of interferon (IFN), which proved to be mainly IFN-gamma. Even though IFN-gamma was produced upon exposure of LGL to bacteria, anti-IFN-gamma antibodies failed to interfere with induction of c...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.8.2767-2773.1991
更新日期:1991-08-01 00:00:00
abstract::Science has a critical role to play in addressing humanity's most important challenges in the twenty-first century. However, the contemporary scientific enterprise has developed in ways that prevent it from reaching maximum effectiveness and detract from the appeal of a research career. To be effective, the methodolog...
journal_title:Infection and immunity
pub_type: 社论
doi:10.1128/IAI.06184-11
更新日期:2012-03-01 00:00:00
abstract::Analyses of chemical composition in whole cells of Rickettsia tsutsugamushi were performed and compared with those of the other rickettsiae and gram-negative bacteria. The results indicated that R. tsutsugamushi does not contain detectable amounts of 3-deoxy-D-mannooctulosonic acid, heptose, muramic acid, or glucosami...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.9.2290-2292.1987
更新日期:1987-09-01 00:00:00
abstract::Bacterial superantigens (SAgs) have been implicated in inflammatory disease, and SAg-treated mice have increased jejunal T cells. Here we show that T84 cells (a human epithelial cell line) display increased MCP-1 and RANTES mRNA expression and protein production in response to conditioned medium from Staphylococcus au...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.11.6198-6202.1999
更新日期:1999-11-01 00:00:00
abstract::Histophilus somni is capable of intracellular survival within professional phagocytic cells, but the mechanism of survival is not understood. The Fic motif within the direct repeat (DR1)/DR2 domains of the IbpA fibrillary network protein of H. somni is cytotoxic to epithelial and phagocytic cells, which may interfere ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00365-18
更新日期:2018-11-20 00:00:00
abstract::Previous studies found that normal human serum (NHS) contains an immunoglobulin G (IgG) antibody that mediates initiation of the classical complement pathway by nonencapsulated Cryptococcus neoformans. The present study used an enzyme-linked immunosorbent assay with whole nonencapsulated yeast cells as solid-phase ant...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.1.215-220.1994
更新日期:1994-01-01 00:00:00
abstract::Peru-15 is a live attenuated oral vaccine derived from a Vibrio cholerae O1 El Tor Inaba strain by a series of deletions and modifications, including deletion of the entire CT genetic element. Peru-15 is also a stable, motility-defective strain and is unable to recombine with homologous DNA. We wished to determine whe...
journal_title:Infection and immunity
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1128/iai.70.4.1965-1970.2002
更新日期:2002-04-01 00:00:00
abstract::T lymphocyte subpopulations in the peripheral blood of children with congenital cytomegalovirus infections and in controls were enumerated with monoclonal antibodies. Infants of less than 1 year of age with symptomatic infections showed significant increases in the proportion of suppressor cells and decreases in the r...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.41.3.1380-1382.1983
更新日期:1983-09-01 00:00:00
abstract::Mast cell-deficient W/Wv mice and their mast cell-sufficient littermates were given infections of Trichinella spiralis. W/Wv mice were slower than their littermates to expel adult T. spiralis. Repair of the mast cell deficiency of W/Wv mice by bone marrow grafting was accompanied by accelerated expulsion of T. spirali...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.41.1.445-447.1983
更新日期:1983-07-01 00:00:00
abstract::Some strains of Streptococcus mutans were found to recognize and bind collagen type I. Binding of 125I-labeled collagen type I was specific in that collagen types I and II, but not unrelated proteins, were able to inhibit binding of the labeled ligand to bacteria. Collagen binding to S. mutans was partially reversible...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.10.4119-4125.1993
更新日期:1993-10-01 00:00:00
abstract::Improvement of antibody responses to polysaccharides through their linkage to proteins is thought to be mediated by protein-specific T helper (Th) cells. To investigate whether the carrier protein of a conjugate could be substituted by a Th epitope, Streptococcus pneumoniae type 17F polysaccharide (PS) was bromoacetyl...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.3.961-968.1995
更新日期:1995-03-01 00:00:00
abstract::Relapsing fever (RF) is a spirochetal infection characterized by relapses of a febrile illness and spirochetemia due to the sequential appearance and disappearance of isogenic serotypes in the blood. The only difference between isogenic serotypes is the variable major outer membrane lipoprotein. In the absence of spec...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00538-06
更新日期:2006-11-01 00:00:00
abstract::In the present study, the role of virulence factors in and the effect of opsonization on the interactions between Bordetella pertussis and human monocytes were investigated. The methods used facilitated the distinction between attachment and ingestion of bacteria by monocytes. Nonopsonized virulent B. pertussis cells ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.11.4818-4824.1994
更新日期:1994-11-01 00:00:00
abstract::Syphilis has been recognized as a disease since the late 1400s, yet there is no practical vaccine available. One impediment to the development of a vaccine is the lack of understanding of multiple reinfections in humans despite the development of robust immune responses during the first episode. It has been shown that...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.10.5605-5612.2003
更新日期:2003-10-01 00:00:00
abstract::Neisseria gonorrhoeae is an obligate human pathogen that causes the common sexually transmitted infection gonorrhea. Gonococcal infections cause significant morbidity, particularly among women, as the organism ascends to the upper reproductive tract, resulting in pelvic inflammatory disease, ectopic pregnancy, and inf...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.05806-11
更新日期:2011-12-01 00:00:00
abstract::In vitro studies have shown that enterotoxigenic Escherichia coli (ETEC) strains are capable of invading cultured epithelial cells derived from the human ileum and colon. Two separate invasion loci (tia and tib) have previously been isolated from the classical ETEC strain H10407. The tia locus has been shown to direct...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.12.6595-6601.2000
更新日期:2000-12-01 00:00:00
abstract::Tissue macrophages are the obligatory host cells for Leishmania donovani, the causative agent of visceral leishmaniasis. In this study we sought to determine whether activated macrophages, as defined by the functional criterion of tumor cell cytotoxicity, were also able to exert a microbicidal effect on ingested L. do...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.33.3.918-926.1981
更新日期:1981-09-01 00:00:00