Differential regulation of in vitro humoral and cellular immune responsiveness in Brugia pahangi-infected jirds.

abstract：:Infection with the protozoan parasite Toxoplasma gondii is transmitted to humans from infected animals by tissue cysts and oocysts excreted by cats. Immunization with inactivated parasites or recombinant proteins has at best shown partial protection. We constructed a plasmid expressing the SAG1 surface antigen of T. g...

journal_title：Infection and immunity

authors： Nielsen HV,Lauemøller SL,Christiansen L,Buus S,Fomsgaard A,Petersen E

更新日期：1999-12-01 00:00:00

abstract：:A simple and convenient method was developed for the preparation of Streptococcus pneumoniae type 14 polysaccharide (Pn14PS)-tetanus toxoid (TT) conjugate vaccines, using terminally linked Pn14PS fragments of different lengths. Native Pn14PS was simultaneously depolymerized and activated for conjugation by partial N-d...

journal_title：Infection and immunity

authors： Laferriere CA,Sood RK,de Muys JM,Michon F,Jennings HJ

更新日期：1998-06-01 00:00:00

abstract：:K99 prepared by acid precipitation hemagglutinated guinea pig erythrocytes, whereas K99 prepared by chromatography on diethylaminoethyl-Sephadex did not. K99 purified by either procedure hemagglutinated horse erythrocytes. K99 prepared by acid precipitation contained a second antigen not presnet in the K99 prepared by...

journal_title：Infection and immunity

authors： Isaacson RE

更新日期：1978-11-01 00:00:00

abstract：:Randomly bred guinea pigs were infected with Listeria monocytogenes using the intracardial, intravenous and intraperitoneal routes of infection. Doses of Listeria ranged from 5 to 1,000 x the 50% lethal dose based on the 50% lethal dose for intracardially injected Listeria. A complete necropsy was performed on all ani...

journal_title：Infection and immunity

authors： Dustoor M,Croft W,Fulton A,Blazkovec A

更新日期：1977-03-01 00:00:00

abstract：:Infection with Shiga toxin (Stx)-producing bacteria and the subsequent release of Stxs and endotoxins into the bloodstream may damage blood vessels in the colon, kidneys, and central nervous system, leading to bloody diarrhea, acute renal failure, and neurological complications. The proinflammatory cytokines tumor nec...

journal_title：Infection and immunity

authors： Harrison LM,van Haaften WC,Tesh VL

更新日期：2004-05-01 00:00:00

abstract：:A novel immunobiologically active fraction was prepared from a phenol-water extract of Prevotella intermedia ATCC 25611 by Sephadex G-100 column chromatography. The fraction consisted mainly of carbohydrate and protein and was devoid of fatty acid. The fraction showed high-molecular-weight bands (10,000 to 12,000) on ...

journal_title：Infection and immunity

authors： Iki K,Kawahara K,Sawamura S,Arakaki R,Sakuta T,Sugiyama A,Tamura H,Sueda T,Hamada S,Takada H

更新日期：1997-11-01 00:00:00

abstract：:Naturally occurring antibodies for Vibrio fetus with whole-cell and O antigen specificities were detected in sera of mature cattle by means of the agglutination and indirect immunofluorescence reactions. O antibodies occurred in each of 21 sera examined, and whole-cell antibodies, in lower concentrations, occurred in ...

journal_title：Infection and immunity

authors： Duncan JR,Wilkie BN,Winter AJ

更新日期：1972-05-01 00:00:00

abstract：:CD8 T cells are effective mediators of specific immunity to infection by Listeria monocytogenes, a bacterial pathogen that initially infects macrophages in the spleen and liver and subsequently spreads to hepatocytes and unidentified parenchymal cells in the spleen. To identify the in vivo target cells of L. monocytog...

journal_title：Infection and immunity

authors： Harty JT,Bevan MJ

更新日期：1996-09-01 00:00:00

abstract：:Gnotobiotic calves were inoculated with an O5:K4:H-, urease-positive strain of Escherichia coli isolated from a 2-day-old calf with diarrhea. The calves developed elevated temperatures and passed loose mucoid feces, with or without blood. The E. coli strain was negative for heat-stable and heat-labile enterotoxins but...

journal_title：Infection and immunity

authors： Moxley RA,Francis DH

更新日期：1986-08-01 00:00:00

abstract：:A set of four monoclonal antibodies was produced against a highly purified pepsin extract of type 5 streptococcal M protein. Three of the four antibodies cross-reacted with purified M proteins from heterologous serotypes and opsonized the respective heterologous organisms. Our studies suggest that monoclonal antibodie...

journal_title：Infection and immunity

authors： Dale JB,Beachey EH

更新日期：1984-10-01 00:00:00

abstract：:This study examined apoptotic cell death associated with Shiga-like toxin (Stx)-producing Escherichia coli. Renal cortices from three children with postenteropathic hemolytic-uremic syndrome (HUS) and from mice infected with E. coli O157:H7 and pediatric renal tubular epithelial cells stimulated with Stx and E. coli O...

journal_title：Infection and immunity

authors： Karpman D,Håkansson A,Perez MT,Isaksson C,Carlemalm E,Caprioli A,Svanborg C

更新日期：1998-02-01 00:00:00

abstract：:The effect of ingestion of heat-killed Histoplasma capsulatum yeast cells on the metabolism of arachidonic acid (20:4) to prostenoids and leukotrienes was examined in murine peritoneal macrophages (M phi s). H. capsulatum-containing M phi s exhibited a metabolite profile similar to that of zymosan-challenged phagocyte...

journal_title：Infection and immunity

authors： Wolf JE,Massof SE,Peters SP

更新日期：1992-07-01 00:00:00

abstract：:Periodontitis is a disease of polymicrobial etiology characterized by inflammation, degradation of host tissue, and bone that irreversibly destroys the supporting apparatus of teeth. Porphyromonas gingivalis contains lipid A with structural heterogeneity that has been postulated to contribute to the initiation of dysb...

journal_title：Infection and immunity

authors： Zenobia C,Hasturk H,Nguyen D,Van Dyke TE,Kantarci A,Darveau RP

更新日期：2014-02-01 00:00:00

abstract：:Resurgence is a major concern after malaria elimination. After the initiation of the elimination program on Aneityum Island in 1991, microscopy showed that Plasmodium falciparum disappeared immediately, whereas P. vivax disappeared from 1996 onward, until P. vivax cases were reported in January 2002. By conducting mal...

journal_title：Infection and immunity

authors： Kaneko A,Chaves LF,Taleo G,Kalkoa M,Isozumi R,Wickremasinghe R,Perlmann H,Takeo S,Tsuboi T,Tachibana S,Kimura M,Björkman A,Troye-Blomberg M,Tanabe K,Drakeley C

更新日期：2014-01-01 00:00:00

abstract：:Staphylococcus aureus peptidoglycan displayed a marked dose-dependent mitogenic activity for mouse splenocytes and human peripheral blood lymphocytes in vitro, as measured by increased [3H]thymidine incorporation. Similarly it was mitogenic for athymic nude mouse spleen cells, whereas no blastogenic effect was observe...

journal_title：Infection and immunity

authors： Dziarski R,Dziarski A

更新日期：1979-03-01 00:00:00

abstract：:We recently determined that passive transfer of serum directed against a synthetic peptide called LB1 or a recombinant fusion protein immunogen [LPD-LB1(f)(2,1,3)] could prevent otitis media after challenge with a homologous nontypeable Haemophilus influenzae (NTHI) isolate. NTHI residing in the nasopharynx was rapidl...

journal_title：Infection and immunity

authors： Kennedy BJ,Novotny LA,Jurcisek JA,Lobet Y,Bakaletz LO

更新日期：2000-05-01 00:00:00

abstract：:Colonization by Bordetella bronchiseptica results in a variety of inflammatory respiratory infections, including canine kennel cough, porcine atrophic rhinitis, and a whooping cough-like disease in humans. For successful colonization, B. bronchiseptica must acquire iron (Fe) from the infected host. A vast amount of Fe...

journal_title：Infection and immunity

authors： Mocny JC,Olson JS,Connell TD

更新日期：2007-10-01 00:00:00

abstract：:Natural heterogeneity in the structure of the lipid A portion of lipopolysaccharide (LPS) produces differential effects on the innate immune response. Gram-negative bacterial species produce LPS structures that differ from the classic endotoxic LPS structures. These differences include hypoacylation and hypophosphoryl...

journal_title：Infection and immunity

authors： Chilton PM,Hadel DM,To TT,Mitchell TC,Darveau RP

更新日期：2013-09-01 00:00:00

abstract：:To study the immunological activity of proteins secreted by Mycobacterium tuberculosis, we carried out comparative studies in guinea pigs infected intravenously with 2.5 x 10(3) CFU of this organism or with 2.5 x 10(4) CFU of Mycobacterium bovis BCG. Groups of infected guinea pigs were skin tested with fractions of se...

journal_title：Infection and immunity

authors： Hasløv K,Andersen A,Nagai S,Gottschau A,Sørensen T,Andersen P

更新日期：1995-03-01 00:00:00

abstract：:Malaria infection caused by Plasmodium parasites continues to cause enormous morbidity and mortality in areas where it is endemic, and there is no licensed vaccine capable of inducing sterile protection. Hyperimmunization with attenuated whole sporozoites can induce sterile protective immune responses targeting preery...

journal_title：Infection and immunity

authors： Billman ZP,Seilie AM,Murphy SC

更新日期：2016-07-21 00:00:00

abstract：:Mutant cultures that lacked the ability to produce filamentous hemagglutinin were obtained by UV irradiation of Bordetella pertussis strain 18-323. Various biological activities of these mutants were compared with those of the parent culture. It was found that the leukocytosis-promoting, histamine-sensitizing, and mou...

journal_title：Infection and immunity

authors： Watanabe M,Nakase Y

更新日期：1982-03-01 00:00:00

abstract：:Only listeriolysin O (LLO)-producing strains of Listeria monocytogenes generate protective immunity in mice. Based on the findings that endogenous gamma interferon (IFN-gamma) production was induced only by such strains and that purified LLO could induce IFN-gamma from NK cells, we have postulated that LLO may play a ...

journal_title：Infection and immunity

authors： Tanabe Y,Xiong H,Nomura T,Arakawa M,Mitsuyama M

更新日期：1999-02-01 00:00:00

abstract：:Lipooligosaccharide (LOS) is a major surface component of Moraxella catarrhalis and a possible virulence factor in the pathogenesis of human infections caused by this organism. The presence of LOS on the bacterium is an obstacle to the development of vaccines derived from whole cells or outer membrane components of th...

journal_title：Infection and immunity

authors： Peng D,Hong W,Choudhury BP,Carlson RW,Gu XX

更新日期：2005-11-01 00:00:00

abstract：:Cell-free hemoglobin (Hb) is being developed as an erythrocyte substitute. We have previously demonstrated that cell-free Hb is an endotoxin-binding protein which disaggregates endotoxin and subsequently increases the biological activity of endotoxin in several in vitro assays. Because much of the morbidity and mortal...

journal_title：Infection and immunity

authors： Su D,Roth RI,Yoshida M,Levin J

更新日期：1997-04-01 00:00:00

abstract：:An antiserum, C16, was raised in cattle against freeze-thawed extracts of sporozoites of Theileria parva (Muguga). This antiserum, which neutralizes sporozoite infectivity in vitro, identified theileria-specific antigens having approximate molecular masses of 105, 90, 85, 69, 67, 52, 47, and 43 kilodaltons (kDa) on We...

journal_title：Infection and immunity

authors： Iams KP,Hall R,Webster P,Musoke AJ

更新日期：1990-06-01 00:00:00

abstract：:NF-κB is a critical regulator of gene expression during severe infections. NF-κB comprises homo- and heterodimers of proteins from the Rel family. Among them, p50 and p65 have been clearly implicated in the pathophysiology of sepsis. In contrast, the role of cRel in sepsis is still controversial and has been poorly st...

journal_title：Infection and immunity

authors： Courtine E,Pène F,Cagnard N,Toubiana J,Fitting C,Brocheton J,Rousseau C,Gerondakis S,Chiche JD,Ouaaz F,Mira JP

更新日期：2011-05-01 00:00:00

abstract：:Resistance to cutaneous syphilitic reinfection in strain 2 and strain 13 guinea pigs developed gradually 3 to 7 months after primary infection and reached maximum levels at 6 to 7 months after the induction of primary cutaneous disease. Associated with this acquired resistance was the occurrence of Arthus reactions an...

journal_title：Infection and immunity

authors： Pavia CS,Niederbuhl CJ

更新日期：1985-10-01 00:00:00

abstract：:Infection by Shigella flexneri is characterized by infiltration of neutrophils in the intestinal mucosa and by a strong inflammatory reaction. Although neutrophils are constitutively programmed to die by apoptosis, we show that isolated human neutrophils undergo necrosis 2 h after infection with virulent S. flexneri s...

journal_title：Infection and immunity

authors： François M,Le Cabec V,Dupont MA,Sansonetti PJ,Maridonneau-Parini I

更新日期：2000-03-01 00:00:00

abstract：:A heterogeneous subset of extraintestinal pathogenic Escherichia coli (ExPEC) strains, referred to as uropathogenic E. coli (UPEC), causes most uncomplicated urinary tract infections. However, no core set of virulence factors exists among UPEC strains. Instead, the focus of the analysis of urovirulence has shifted to ...

journal_title：Infection and immunity

authors： Engstrom MD,Alteri CJ,Mobley HL

更新日期：2014-09-01 00:00:00

abstract：:The immunoprotective activity of Klebsiella pneumoniae K2 cell surface preparations and purified capsular polysaccharide was tested in mice. The 50% protective dose (PD50), expressed as capsular polysaccharide content, was 2 ng for cell surface preparations and 50 ng for purified capsular polysaccharide. Both preparat...

journal_title：Infection and immunity

authors： Robert A,Jouin H,Fournier JM

更新日期：1986-11-01 00:00:00