EXPERIMENTAL VIABLE VACCINE AGAINST PULMONARY COCCIDIOIDOMYCOSIS IN MONKEYS.

Abstract:

:Converse, John L. (U.S. Army Biological Laboratories, Fort Detrick, Frederick, Md.), Merida W. Castleberry, and Ernest M. Snyder. Experimental viable vaccine against pulmonary coccidioidomycosis in monkeys. J. Bacteriol. 86:1041-1051. 1963.-Monkeys (Macaca mulatta) vaccinated by subcutaneous injection in the forearm with from 10 to 10(8) viable Coccidioides immitis arthrospores were protected against respiratory challenge with approximately 7000 viable arthrospores administered 6 months after vaccination. Protection was evident from: the healthy appearance throughout 4 months after respiratory challenge; negative chest X rays at 15, 30, 60, and 120 days; and only very minor histopathological pulmonary changes on autopsy at 120 days, with negative lung cultures in 80% of the animals. This was in striking contrast to the outward clinical appearance of control monkeys that were unvaccinated or had received nonviable arthrospore vaccines. These monkeys showed severe disease (loss of weight, accelerated respiration, severe coughing, general debilitation), positive X rays, massive pulmonary destruction, positive lung cultures, and death of five of nine animals. The appearance of spherules (very few in number, accompanied by very minor pathological changes) in the lungs of some of the "dissemination controls" (subcutaneous viable vaccination without respiratory challenge) indicated possible dissemination from the primary cutaneous infection, although oral transmission from the cutaneous lesions could not be ruled out.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

CONVERSE JL,CASTLEBERRY MW,SNYDER EM

doi

10.1128/JB.86.5.1041-1051.1963

keywords:

subject

Has Abstract

pub_date

1963-11-01 00:00:00

pages

1041-51

eissn

0021-9193

issn

1098-5530

journal_volume

86

pub_type

杂志文章
  • Beta-2-linked glucans secreted by fast-growing species of Rhizobium.

    abstract::Fast-growing species of Rhizobium were found to secrete low-molecular-weight beta-2-linked glucans when cultured in synthetic liquid medium. These glucans are quite similar to beta-2-linked glucans produced by species of Agrobacterium. No reducing terminus was detected in these glucans. ...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.142.1.243-248.1980

    authors: York WS,McNeil M,Darvill AG,Albersheim P

    更新日期:1980-04-01 00:00:00

  • Assimilatory sulfate reduction in an Escherichia coli mutant lacking thioredoxin activity.

    abstract::An investigation of sulfate reduction in B tsnC*7004, a mutant of Escherichia coli lacking thioredoxin, is reported. Although thioredoxin is indispensable for the adenosine 3'-phosphate 5'-phosphosulfate (PAPS) sulfotransferase reaction under the usual conditions of assay in extracts of wild-type cells, the mutant gre...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.134.1.131-138.1978

    authors: Tsang ML,Schiff JA

    更新日期:1978-04-01 00:00:00

  • Molecular and catalytic properties of ribulose 1,5-bisphosphate carboxylase from the photosynthetic extreme halophile Ectothiorhodospira halophila.

    abstract::D-Ribulose 1,5-bisphosphate (RuBP) carboxylase has been purified from the photosynthetic extreme halophile Ectothiorhodospira halophila. Despite a growth requirement for almost saturating sodium chloride in the medium, both crude and homogeneous preparations of RuBP carboxylase obtained from this organism were inhibit...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.126.3.1271-1277.1976

    authors: Tabita FR,McFadden BA

    更新日期:1976-06-01 00:00:00

  • The MiaA tRNA modification enzyme is necessary for robust RpoS expression in Escherichia coli.

    abstract::The stationary phase/general stress response sigma factor RpoS (σ(S)) is necessary for adaptation and restoration of homeostasis in stationary phase. As a physiological consequence, its levels are tightly regulated at least at two levels. Multiple small regulatory RNA molecules modulate its translation, in a manner th...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.01013-13

    authors: Thompson KM,Gottesman S

    更新日期:2014-02-01 00:00:00

  • Evidence for divalent cation (Ca2+)-stabilized oligomeric proteins and covalently bound protein-peptidoglycan complexes in the outer membrane of Rhizobium leguminosarum.

    abstract::Two unusual characteristics of some outer membrane proteins of Rhizobium leguminosarum are described. First, most of the major outer membrane proteins could only be visualized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis after lysozyme treatment of the isolated cell envelopes, suggesting a very strong,...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.171.7.3989-3995.1989

    authors: de Maagd RA,Wientjes FB,Lugtenberg BJ

    更新日期:1989-07-01 00:00:00

  • Molecular characterization of the gene cluster coxMSL encoding the molybdenum-containing carbon monoxide dehydrogenase of Oligotropha carboxidovorans.

    abstract::The CO dehydrogenase structural genes (cox) and orf4 are clustered in the transcriptional order coxM--> coxS--> coxL--> orf4 on the 128-kb megaplasmid pHCG3 of the carboxidotroph Oligotropha carboxidovorans OM5. Sequence analysis suggested association of molybdopterin cytosine dinucleotide and flavin adenine dinucleot...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.177.8.2197-2203.1995

    authors: Schübel U,Kraut M,Mörsdorf G,Meyer O

    更新日期:1995-04-01 00:00:00

  • Characteristics of penicillinase secretion by growing cells and protoplasts of Bacillus licheniformis.

    abstract::Cultures of the inducible penicillinase-producing strain 749 of Bacillus licheniformis, induced with small amounts of benzylpenicillin, synthesized penicillinase at a high rate for a short period, after which the rate of synthesis slowly declined. During the period of active synthesis, the rate of secretion, as a frac...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.97.2.820-826.1969

    authors: Sargent MG,Ghosh BK,Lampen JO

    更新日期:1969-02-01 00:00:00

  • The C-terminal portion of the tail fiber protein of bacteriophage lambda is responsible for binding to LamB, its receptor at the surface of Escherichia coli K-12.

    abstract::Bacteriophage lambda adsorbs to its Escherichia coli K-12 host by interacting with LamB, its cell-surface receptor. We fused C-terminal portions of J, the tail fiber protein of lambda, to maltose-binding protein. Solid-phase binding assays demonstrated that a purified fusion protein comprising only the last 249 residu...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.182.2.508-512.2000

    authors: Wang J,Hofnung M,Charbit A

    更新日期:2000-01-01 00:00:00

  • Separation of beta-factor synthesis from stimulated beta-carotene synthesis in mated cultures of Blakeslea trispora.

    abstract::Mated cultures of Blakeslea trispora, grown in a potato extract-glucose-thiamine medium, produced 10 to 15 times more beta-carotene than either unmated culture. Mated, but not unmated, cultures produced a family of compounds (beta factor) which stimulated carotenogenesis in unmated cultures. In fact, carotenogenesis w...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.95.2.426-432.1968

    authors: Sutter RP,Rafelson ME Jr

    更新日期:1968-02-01 00:00:00

  • Genetic and molecular analyses of the gene encoding staphylococcal enterotoxin D.

    abstract::The gene (entD) encoding staphylococcal enterotoxin D (SED) has been located on a 27.6-kilobase penicillinase plasmid designated pIB485. This plasmid was present in all SED-producing strains tested. The entD gene was cloned on a 2.0-kilobase DNA fragment and was expressed in Escherichia coli. Sequence analysis of this...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.171.9.4799-4806.1989

    authors: Bayles KW,Iandolo JJ

    更新日期:1989-09-01 00:00:00

  • A modular family 19 chitinase found in the prokaryotic organism Streptomyces griseus HUT 6037.

    abstract::The specificity of chitinase C-1 of Streptomyces griseus HUT 6037 for the hydrolysis of the beta-1,4-glycosidic linkages in partially acetylated chitosan is different from that of other microbial chitinases. In order to study the primary structure of this unique chitinase, the chiC gene specifying chitinase C-1 was cl...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.178.17.5065-5070.1996

    authors: Ohno T,Armand S,Hata T,Nikaidou N,Henrissat B,Mitsutomi M,Watanabe T

    更新日期:1996-09-01 00:00:00

  • Deoxyribonucleate binding and transformation in Rhizobium jpaonicum.

    abstract::Rhizobium japonicum, capable of binding high-molecular-weight donor (32)P-labeled deoxyribonucleic acid (DNA) during late log phase in a competence medium, was transformed for streptomycin resistance with a frequency of transformation ranging between 0.02 and 0.08%. Eight to 10% of the homologous native (32)P-labeled ...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.111.2.356-360.1972

    authors: Raina JL,Modi VV

    更新日期:1972-08-01 00:00:00

  • Response and specificity of antibodies for Shigella flexneri: demonstration of type-specific factors in immunoglobulin G fraction of antiserum.

    abstract::Considerable amounts of immunoglobulin G (IgG) antibody appeared in hyperimmune rabbit serum at a late period during a course of immunization with several injections of Shigella flexneri O antigens. High yields of IgG antibody possessing homogenous specificity could be fractionated from crude gamma-globulin solution o...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.98.3.1128-1134.1969

    authors: Fukazawa Y,Shinoda T,Tsuchiya T

    更新日期:1969-06-01 00:00:00

  • Anaerobic regulation of the hydrogenase 1 (hya) operon of Escherichia coli.

    abstract::Using a transcriptional fusion to the lacZ gene, we have analyzed the anaerobic regulation of the hydrogenase 1 (hya) operon in response to different anaerobic growth conditions and to mutations in regulatory genes. We found that the transcription of the hya operon was induced when the growth condition was changed fro...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.176.17.5423-5428.1994

    authors: Brøndsted L,Atlung T

    更新日期:1994-09-01 00:00:00

  • Impact of the N-terminal secretor domain on YopD translocator function in Yersinia pseudotuberculosis type III secretion.

    abstract::Type III secretion systems (T3SSs) secrete needle components, pore-forming translocators, and the translocated effectors. In part, effector recognition by a T3SS involves their N-terminal amino acids and their 5' mRNA. To investigate whether similar molecular constraints influence translocator secretion, we scrutinize...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.00210-11

    authors: Amer AA,Åhlund MK,Bröms JE,Forsberg Å,Francis MS

    更新日期:2011-12-01 00:00:00

  • Messenger ribonucleic acid of dormant spores of Bacillus subtilis.

    abstract::Evidence of the presence of messenger ribonucleic acid (mRNA) in dormant spores of Bacillus subtilis has been obtained. The bulk RNA from spores was isolated and labeled in vitro with tritiated dimethyl sulfate. The spore RNA hybridized to 2.4 to 3.2% of the B. subtilis genome. The RNA hybridized to both the complemen...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.119.2.514-521.1974

    authors: Jeng YH,Doi RH

    更新日期:1974-08-01 00:00:00

  • Genetic characterization of the nucleotide excision repair system of Neisseria gonorrhoeae.

    abstract::Nucleotide excision repair (NER) is universally used to recognize and remove many types of DNA damage. In eubacteria, the NER system typically consists of UvrA, UvrB, UvrC, the UvrD helicase, DNA polymerase I, and ligase. In addition, when DNA damage blocks transcription, transcription-repair coupling factor (TRCF), t...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.01018-09

    authors: LeCuyer BE,Criss AK,Seifert HS

    更新日期:2010-02-01 00:00:00

  • Detoxification of protoanemonin by dienelactone hydrolase.

    abstract::Protoanemonin is a toxic metabolite which may be formed during the degradation of some chloroaromatic compounds, such as polychlorinated biphenyls, by natural microbial consortia. We show here that protoanemonin can be transformed by dienelactone hydrolase of Pseudomonas sp. strain B13 to cis-acetylacrylate. Although ...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.180.2.400-402.1998

    authors: Brückmann M,Blasco R,Timmis KN,Pieper DH

    更新日期:1998-01-01 00:00:00

  • Multiplicity of 3-Ketosteroid-9α-Hydroxylase enzymes in Rhodococcus rhodochrous DSM43269 for specific degradation of different classes of steroids.

    abstract::The well-known large catabolic potential of rhodococci is greatly facilitated by an impressive gene multiplicity. This study reports on the multiplicity of kshA, encoding the oxygenase component of 3-ketosteroid 9α-hydroxylase, a key enzyme in steroid catabolism. Five kshA homologues (kshA1 to kshA5) were previously i...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.00274-11

    authors: Petrusma M,Hessels G,Dijkhuizen L,van der Geize R

    更新日期:2011-08-01 00:00:00

  • Cholera toxins: immunogenicity of the rabbit ileal loop toxin and related antigens.

    abstract::A method of assay of immunogenic potency of the cholera gut toxin is described; it is based on the relation of dose of antigen to neutralizing antibody titer produced in the rabbit under defined conditions and allows quantification of immunogenicity as immunogenic units per milligram of protein. Evidence, based on imm...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.100.2.985-993.1969

    authors: Kaur J,Burrows W,Cercavski L

    更新日期:1969-11-01 00:00:00

  • Conserved cytoplasmic loops are important for both the transport and chemotaxis functions of PcaK, a protein from Pseudomonas putida with 12 membrane-spanning regions.

    abstract::Chemotaxis to the aromatic acid 4-hydroxybenzoate (4-HBA) by Pseudomonas putida is mediated by PcaK, a membrane-bound protein that also functions as a 4-HBA transporter. PcaK belongs to the major facilitator superfamily (MFS) of transport proteins, none of which have so far been implicated in chemotaxis. Work with two...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.181.16.5068-5074.1999

    authors: Ditty JL,Harwood CS

    更新日期:1999-08-01 00:00:00

  • Cloning and nucleotide sequence of celA1, and endo-beta-1,4-glucanase-encoding gene from Streptomyces halstedii JM8.

    abstract::The celA1 gene encoding an endo-beta-1,4-glucanase from a mesophilic actinomycete, strain JM8, identified as Streptomyces halstedii, was cloned and expressed in S. lividans JI66. From the nucleotide sequence of a 1.7-kb DNA fragment we identified an open reading frame of 963 nucleotides encoding a protein of 321 amino...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.174.20.6368-6376.1992

    authors: Fernández-Abalos JM,Sánchez P,Coll PM,Villanueva JR,Pérez P,Santamaría RI

    更新日期:1992-10-01 00:00:00

  • Mutations affecting mRNA processing and fimbrial biogenesis in the Escherichia coli pap operon.

    abstract::The Escherichia coli pap genetic determinant includes 11 genes and encodes expression of Pap pili on the bacterial surface. An RNase E-dependent mRNA-processing event in the intercistronic papB-papA region results in the accumulation of a papA-gene-specific mRNA in considerable excess of the primary papB-papA mRNA tra...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.178.3.683-690.1996

    authors: Nilsson P,Naureckiene S,Uhlin BE

    更新日期:1996-02-01 00:00:00

  • Duplication of the tuf gene, which encodes peptide chain elongation factor Tu, is widespread in Gram-negative bacteria.

    abstract::The tuf gene which encodes peptide chain elongation factor Tu was found to be duplicated in nine enteric and four nonenteric gram-negative bacteria, but present only in one copy in two gram-positive genera. In two of the nonenteric gram-negative genera, Pseudomonas and Caulobacter, the duplicate tuf genes were found t...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.148.3.1006-1011.1981

    authors: Filer D,Furano AV

    更新日期:1981-12-01 00:00:00

  • Control of EpsE, the phosphoglycosyltransferase initiating exopolysaccharide synthesis in Streptococcus thermophilus, by EpsD tyrosine kinase.

    abstract::We studied the roles of Streptococcus thermophilus phosphogalactosyltransferase (EpsE) (the priming enzyme), tyrosine kinase (EpsD), phosphatase (EpsB), and a membrane-associated protein with no known biochemical function (EpsC) in exopolysaccharide (EPS) synthesis. These proteins are well-conserved among bacteria and...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.01122-06

    authors: Minic Z,Marie C,Delorme C,Faurie JM,Mercier G,Ehrlich D,Renault P

    更新日期:2007-02-01 00:00:00

  • Estimations of bacterial growth rates in natural waters.

    abstract::Specific growth rates as low as 0.005 hr(-1) (generation times of 20 to 200 hr) of aquatic bacteria in natural waters have been calculated from significant differences between dilution rates and washout rates in a chemostat. The measured growth rates were affected by the treatment of the water samples (type of sterili...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.99.1.156-160.1969

    authors: Jannasch HW

    更新日期:1969-07-01 00:00:00

  • Physical and functional interactions between Escherichia coli MutY glycosylase and mismatch repair protein MutS.

    abstract::Escherichia coli MutY and MutS increase replication fidelity by removing adenines that were misincorporated opposite 7,8-dihydro-8-oxo-deoxyguanines (8-oxoG), G, or C. MutY DNA glycosylase removes adenines from these mismatches through a short-patch base excision repair pathway and thus prevents G:C-to-T:A and A:T-to-...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.01513-06

    authors: Bai H,Lu AL

    更新日期:2007-02-01 00:00:00

  • Selective depletion of Sulfolobus solfataricus transcription factor E under heat shock conditions.

    abstract::Archaeal transcriptional machinery is similar to that of eukaryotes. We studied the fates of various components of the Sulfolobus solfataricus transcriptional apparatus under different stresses and found that in cells incubated at 90 degrees C for 1 h, transcription factor E (TFE) is selectively depleted, but its mRNA...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.01534-09

    authors: Iqbal J,Qureshi SA

    更新日期:2010-06-01 00:00:00

  • Deoxycytidine triphosphate deaminase: characterization of an Escherichia coli mutant deficient in the enzyme.

    abstract::A mutant of Escherichia coli, previously shown to contain abnormal nucleoside triphosphate pools, was found to be defective in its ability to synthesize thymidine nucleotides. The defect is not in the enzyme thymidylate synthetase but in deoxycytidine triphosphate deaminase, an enzyme that supplies deoxyuridine monoph...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.105.2.666-672.1971

    authors: O'Donovan GA,Edlin G,Fuchs JA,Neuhard J,Thomassen E

    更新日期:1971-02-01 00:00:00

  • Cloning, expression, and characterization of the Micromonospora viridifaciens neuraminidase gene in Streptomyces lividans.

    abstract::We have cloned the Micromonospora viridifaciens neuraminidase (EC 3.2.1.18) gene (nedA) in Streptomyces lividans. This was accomplished by using the vector pIJ702 and BglII-BclI libraries of M. viridifaciens chromosomal inserts created in S. lividans. The libraries were screened for the expression of neuraminidase by ...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.174.21.6896-6903.1992

    authors: Sakurada K,Ohta T,Hasegawa M

    更新日期:1992-11-01 00:00:00